Aliases for CALU Gene
External Ids for CALU Gene
Previous GeneCards Identifiers for CALU Gene
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
GeneCards Summary for CALU Gene
CALU (Calumenin) is a Protein Coding gene. Diseases associated with CALU include Coumarin Resistance. Among its related pathways are Warfarin Pathway, Pharmacodynamics and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN1.
UniProtKB/Swiss-Prot Summary for CALU Gene
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).