Aliases for CALR3 Gene
External Ids for CALR3 Gene
Previous GeneCards Identifiers for CALR3 Gene
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
GeneCards Summary for CALR3 Gene
CALR3 (Calreticulin 3) is a Protein Coding gene. Diseases associated with CALR3 include Hypertrophic Cardiomyopathy and In Situ Pulmonary Adenocarcinoma. Gene Ontology (GO) annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is CALR.
UniProtKB/Swiss-Prot Summary for CALR3 Gene
During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.