Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. ... See more...

Aliases for CALR Gene

Aliases for CALR Gene

  • Calreticulin 2 3 4 5
  • Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin) 2 3
  • Endoplasmic Reticulum Resident Protein 60 3 4
  • Calregulin 3 4
  • CC1qR 2 3
  • CRP55 3 4
  • ERp60 3 4
  • HACBP 3 4
  • Grp60 3 4
  • CRT 2 3
  • SSA 2 3
  • RO 2 3
  • Epididymis Secretory Sperm Binding Protein Li 99n 3
  • Autoantigen Ro 2
  • HEL-S-99n 3
  • FLJ26680 2
  • CALR 5
  • CRTC 4

External Ids for CALR Gene

Previous GeneCards Identifiers for CALR Gene

  • GC19P013180
  • GC19P013272
  • GC19P012894
  • GC19P012910
  • GC19P013049
  • GC19P012621

Summaries for CALR Gene

Entrez Gene Summary for CALR Gene

  • Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]

CIViC Summary for CALR Gene

GeneCards Summary for CALR Gene

CALR (Calreticulin) is a Protein Coding gene. Diseases associated with CALR include Myelofibrosis and Thrombocythemia 1. Among its related pathways are Neuroscience and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CALR3.

UniProtKB/Swiss-Prot Summary for CALR Gene

  • Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Gene Wiki entry for CALR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALR Gene

Genomics for CALR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CALR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALR

Top Transcription factor binding sites by QIAGEN in the CALR gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CUTL1
  • Nkx2-5
  • p53

Genomic Locations for CALR Gene

Genomic Locations for CALR Gene
chr19:12,938,578-12,944,489
(GRCh38/hg38)
Size:
5,912 bases
Orientation:
Plus strand
chr19:13,049,392-13,055,304
(GRCh37/hg19)
Size:
5,913 bases
Orientation:
Plus strand

Genomic View for CALR Gene

Genes around CALR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALR Gene

Proteins for CALR Gene

  • Protein details for CALR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27797-CALR_HUMAN
    Recommended name:
    Calreticulin
    Protein Accession:
    P27797
    Secondary Accessions:
    • Q6IAT4
    • Q9UDG2

    Protein attributes for CALR Gene

    Size:
    417 amino acids
    Molecular mass:
    48142 Da
    Quaternary structure:
    • Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21 (PubMed:8666824). Interacts with NR3C1 (PubMed:11149926). Interacts with PPIB (PubMed:20801878). Interacts (via P-domain) with PDIA5 (PubMed:23614004). Interacts with GABARAP (PubMed:19154346). Interacts with HLA-E-B2M and HLA-G-B2M complexes (PubMed:9427624, PubMed:9640257). Interacts with HLA-F (PubMed:10605026). Interacts with CLCC1 (PubMed:30157172).

    Three dimensional structures from OCA and Proteopedia for CALR Gene

neXtProt entry for CALR Gene

Post-translational modifications for CALR Gene

  • Glycosylation at Asn344
  • Ubiquitination at Lys24, Lys48, Lys55, and Lys159
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for CALR Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for CALR Gene

Domains & Families for CALR Gene

Gene Families for CALR Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CALR Gene

Suggested Antigen Peptide Sequences for CALR Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58668, highly similar to Calreticulin (B4E2Y9_HUMAN)
  • grp60 (CALR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P27797

UniProtKB/Swiss-Prot:

CALR_HUMAN :
  • Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
  • Belongs to the calreticulin family.
Domain:
  • Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
  • The interaction with glycans occurs through a binding site in the globular lectin domain.
  • The zinc binding sites are localized to the N-domain.
  • Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CALR: view

Function for CALR Gene

Molecular function for CALR Gene

UniProtKB/Swiss-Prot Function:
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
GENATLAS Biochemistry:
calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa

Phenotypes From GWAS Catalog for CALR Gene

Gene Ontology (GO) - Molecular Function for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding TAS 15474971
GO:0003677 DNA binding NAS 11149926
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IDA 14726956
GO:0005178 integrin binding IPI 1911778
genes like me logo Genes that share ontologies with CALR: view
genes like me logo Genes that share phenotypes with CALR: view

Human Phenotype Ontology for CALR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CALR Gene

MGI Knock Outs for CALR:

Animal Model Products

CRISPR Products

miRNA for CALR Gene

miRTarBase miRNAs that target CALR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CALR Gene

Localization for CALR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALR Gene

Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). Associated with the lytic granules in the cytolytic T-lymphocytes. {ECO:0000269 PubMed:10358038, ECO:0000269 PubMed:8418194}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALR gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
golgi apparatus 4
cytoskeleton 3
mitochondrion 3
lysosome 3
peroxisome 2
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IMP 22377355
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,IDA 8107809
genes like me logo Genes that share ontologies with CALR: view

Pathways & Interactions for CALR Gene

genes like me logo Genes that share pathways with CALR: view

Pathways by source for CALR Gene

2 GeneGo (Thomson Reuters) pathways for CALR Gene
  • Immune response Antigen presentation by MHC class I
  • Transcription_Role of VDR in regulation of genes involved in osteoporosis
2 Qiagen pathways for CALR Gene
  • Androgen Signaling
  • Presenilin-Mediated Signaling
2 Cell Signaling Technology pathways for CALR Gene

Gene Ontology (GO) - Biological Process for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 8107809
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002502 peptide antigen assembly with MHC class I protein complex ISS 11825569
GO:0006355 regulation of transcription, DNA-templated TAS 8107808
genes like me logo Genes that share ontologies with CALR: view

No data available for SIGNOR curated interactions for CALR Gene

Drugs & Compounds for CALR Gene

(52) Drugs for CALR Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved, Vet_approved Nutra Antagonist, Agonist, Full agonist, Target Melatonin receptors MT inhibitor, Endogenous hormone; agonist at MT1 and MT2 398
Antihemophilic factor, human recombinant Approved, Investigational Pharma Target, chaperone 0
Calcium citrate Approved, Investigational Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
Calcium phosphate dihydrate Approved Pharma Target 0

(37) Additional Compounds for CALR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CALR: view

Transcripts for CALR Gene

mRNA/cDNA for CALR Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALR

Alternative Splicing Database (ASD) splice patterns (SP) for CALR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CALR Gene

GeneLoc Exon Structure for
CALR

Expression for CALR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CALR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CALR Gene



Protein tissue co-expression partners for CALR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALR

SOURCE GeneReport for Unigene cluster for CALR Gene:

Hs.515162

Evidence on tissue expression from TISSUES for CALR Gene

  • Nervous system(4.9)
  • Skin(4.9)
  • Eye(4.9)
  • Pancreas(4.9)
  • Liver(4.8)
  • Lung(4.7)
  • Intestine(4.5)
  • Kidney(4.4)
  • Spleen(4)
  • Heart(3.9)
  • Blood(3.9)
  • Stomach(3.8)
  • Bone marrow(3.8)
  • Lymph node(3.7)
  • Muscle(3.7)
  • Thyroid gland(3.5)
  • Bone(3.5)
  • Adrenal gland(3)
  • Gall bladder(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CALR Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • liver
  • spleen
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CALR: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALR Gene

Orthologs for CALR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CALR 30 31
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CALR 30 31
  • 90.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CALR 30 31
  • 89.56 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Calr 30 17 31
  • 88.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Calr 30
  • 87.73 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CALR 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CALR 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CALR 31
  • 88 (a)
OneToOne
CALR3 30
  • 66.38 (n)
Lizard
(Anolis carolinensis)
Reptilia CALR 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia calr 30
  • 76.55 (n)
Str.538 30
African clawed frog
(Xenopus laevis)
Amphibia calr-prov 30
Zebrafish
(Danio rerio)
Actinopterygii calrl2 30 31
  • 73.72 (n)
OneToOne
calr 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9141 30
Fruit Fly
(Drosophila melanogaster)
Insecta Crc 30 31 32
  • 69.9 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004212 30
  • 69.31 (n)
Worm
(Caenorhabditis elegans)
Secernentea crt-1 30 31 32
  • 67.35 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 31
  • 22 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CRT1b 30
  • 59.61 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1564 30
Rice
(Oryza sativa)
Liliopsida Os07g0246200 30
  • 62.81 (n)
Os.7158 30
Barley
(Hordeum vulgare)
Liliopsida Hv.1770 30
Corn
(Zea mays)
Liliopsida Zm.1288 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10660 31
  • 68 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3623 30
Species where no ortholog for CALR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CALR Gene

ENSEMBL:
Gene Tree for CALR (if available)
TreeFam:
Gene Tree for CALR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CALR: view image

Paralogs for CALR Gene

Paralogs for CALR Gene

(2) SIMAP similar genes for CALR Gene using alignment to 4 proteins:

  • CALR_HUMAN
  • K7EJB9_HUMAN
  • K7EL50_HUMAN
  • K7ELE2_HUMAN

Pseudogenes.org Pseudogenes for CALR Gene

genes like me logo Genes that share paralogs with CALR: view

Variants for CALR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALR Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
708616 Benign: not provided 12,940,356(+) C/T SYNONYMOUS_VARIANT
741199 Likely Benign: not provided 12,940,257(+) A/T SYNONYMOUS_VARIANT
761698 Likely Benign: not provided 12,939,465(+) G/T SYNONYMOUS_VARIANT
764942 Benign: not provided 12,939,212(+) A/G MISSENSE_VARIANT
771513 Benign: not provided 12,943,801(+) A/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CALR Gene

Structural Variations from Database of Genomic Variants (DGV) for CALR Gene

Variant ID Type Subtype PubMed ID
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for CALR Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALR Gene

Human Gene Mutation Database (HGMD)
CALR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALR Gene

Disorders for CALR Gene

MalaCards: The human disease database

(52) MalaCards diseases for CALR Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myelofibrosis
  • myelofibrosis with myeloid metaplasia, somatic
thrombocythemia 1
  • thcyt1
essential thrombocythemia
  • essential thrombocythaemia
rubella
  • german measles
heart block, congenital
  • congenital heart block
- elite association - COSMIC cancer census association via MalaCards
Search CALR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CALR_HUMAN
  • Note=CARL somatic mutations are frequently found in myeloproliferative neoplasms lacking JAK2 or MPL mutations. Myeloproliferative neoplasms are chronic myeloid cancers characterized by overproduction of mature blood cells, and may evolve into acute myeloid leukemia. In addition to chronic myeloid leukemia with the BCR-ABL fusion gene, the three most common myeloproliferative neoplasms are essential thrombocythemia, polycythemia vera, and myelofibrosis. {ECO:0000269 PubMed:24325356, ECO:0000269 PubMed:24325359}.

Additional Disease Information for CALR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CALR: view

No data available for Genatlas for CALR Gene

Publications for CALR Gene

  1. Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. (PMID: 10358038) Arosa FA … de Sousa M (The Journal of biological chemistry 1999) 3 4 23
  2. TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. (PMID: 9427624) Braud VM … McMichael AJ (Current biology : CB 1998) 3 4 23
  3. Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo. (PMID: 9640257) Wainwright SD … Holmes CH (Immunology 1998) 3 4 23
  4. Human placental calreticulin: purification, characterization and association with other proteins. (PMID: 7841019) Houen G … Koch C (Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1994) 3 4 23
  5. The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. (PMID: 8418194) Dupuis M … Tschopp J (The Journal of experimental medicine 1993) 3 4 23

Products for CALR Gene

  • View all