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Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. ... See more...
Aliases for CALR Gene
Aliases for CALR Gene
External Ids for CALR Gene
- HGNC: 1455
- Entrez Gene: 811
- Ensembl: ENSG00000179218
- OMIM: 109091
- UniProtKB: P27797
Previous GeneCards Identifiers for CALR Gene
- GC19P013180
- GC19P013272
- GC19P012894
- GC19P012910
- GC19P013049
- GC19P012621
Summaries for CALR Gene
-
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
GeneCards Summary for CALR Gene
CALR (Calreticulin) is a Protein Coding gene. Diseases associated with CALR include Myelofibrosis and Thrombocythemia 1. Among its related pathways are Neuroscience and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CALR3.
UniProtKB/Swiss-Prot Summary for CALR Gene
-
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Additional gene information for CALR Gene
- HGNC(1455)
- Entrez Gene(811)
- Ensembl(ENSG00000179218)
- OMIM(109091)
- UniProtKB(P27797)
- Open Targets Platform(ENSG00000179218)
- Monarch Initiative
- Search for CALR at DataMed
- Search for CALR at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALR Gene
Genomics for CALR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CALR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CALR on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALR
- Top Transcription factor binding sites by QIAGEN in the CALR gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CUTL1
- Nkx2-5
- p53
Genomic Locations for CALR Gene
Genomic Locations for CALR Gene
- chr19:12,938,578-12,944,489
- (GRCh38/hg38)
- Size:
- 5,912 bases
- Orientation:
- Plus strand
- chr19:13,049,392-13,055,304
- (GRCh37/hg19)
- Size:
- 5,913 bases
- Orientation:
- Plus strand
Genomic View for CALR Gene
Genes around CALR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.13 by HGNC
- 19p13.13 by Entrez Gene
- 19p13.13 by Ensembl
CALR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALR Gene
Proteins for CALR Gene
-
Protein details for CALR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P27797-CALR_HUMAN
- Recommended name:
- Calreticulin
- Protein Accession:
- P27797
- Q6IAT4
- Q9UDG2
Protein attributes for CALR Gene
- Size:
- 417 amino acids
- Molecular mass:
- 48142 Da
- Quaternary structure:
-
- Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21 (PubMed:8666824). Interacts with NR3C1 (PubMed:11149926). Interacts with PPIB (PubMed:20801878). Interacts (via P-domain) with PDIA5 (PubMed:23614004). Interacts with GABARAP (PubMed:19154346). Interacts with HLA-E-B2M and HLA-G-B2M complexes (PubMed:9427624, PubMed:9640257). Interacts with HLA-F (PubMed:10605026). Interacts with CLCC1 (PubMed:30157172).
Protein Expression for CALR Gene
Post-translational modifications for CALR Gene
Other Protein References for CALR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CALR
- AM00171PU-N
- AM06211SU-N
- AM31148PU-N
- AP00030PU-N
- AP05311PU-N
- AP17172PU-N
- AP33519PU-N
- CF813228
- CF813229
- CF813230
- CF813231
- SP1087P
- TA309300
- TA312147
- TA321646
- TA321647
- TA326909
- TA327765
- TA329122
- TA329123
- TA336667
- TA336669
- TA336776
- TA344177
- TA344447
- TA344448
- TA813228
- TA813228S
- TA813229
- TA813229S
- TA813230
- TA813230S
- TA813231
- TA813231S
- Novus Biologicals Antibodies for CALR
-
Abcam antibodies for CALR
- Invitrogen Antibodies for CALR (AFLGC-CALR)
- antibodies-online: Show 3 available MGC13138 Antibodies ranked by validation data
- Compare Top MGC13138 Antibodies
-
Recommended
- 284 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 1 Ct Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 163 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 117 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for CALR
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALR
- Sino Biological Antibodies for CALR
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CALR
- Origene Custom Protein Services for CALR
- Sino Biological Recombinant Proteins for CALR
- Sino Biological Cell Lysates for CALR
- ProSpec Recombinant Proteins for CALR
-
ProSci Proteins for CALR
-
Abcam proteins for CALR
Assay Products
- G Biosciences Immunotag™ Human CALR (Calreticulin) ELISA and Immunotag™ Calreticulin ELISA Kit
- RayBiotech Human Calreticulin ELISA
- antibodies-online: Show 74 available MGC13138 Elisa Kits ranked by validation data
- Compare Top MGC13138 Elisa Kits
-
Quality Products:
- ABIN1113916
- ABIN367230
- ABIN4947430
- ABIN1028298
- ABIN5520066
- ABIN5520067
- ABIN5668381
- ABIN5591749
- ABIN510419
- ABIN6384313
- ABIN1113918
- ABIN829171
- ABIN1569192
- ABIN5669719
- ABIN627678
- ABIN5591750
- ABIN5652527
- ABIN6254315
- ABIN2542384
- ABIN2946000
- ABIN1113917
- ABIN1569193
- ABIN5670381
- ABIN578522
- ABIN626858
- ABIN5652528
- ABIN5652529
- ABIN2542385
- ABIN2946002
- ABIN2943975
- ABIN989690
- ABIN1125041
-
Boster Bio ELISA Kits for CALR
-
Signalway ELISA kits for CALR
No data available for DME Specific Peptides for CALR Gene
Domains & Families for CALR Gene
Gene Families for CALR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CALR Gene
- InterPro:
- Blocks:
-
- Calreticulin
- ProtoNet:
Suggested Antigen Peptide Sequences for CALR Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58668, highly similar to Calreticulin (B4E2Y9_HUMAN)
- grp60 (CALR_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P27797UniProtKB/Swiss-Prot:
CALR_HUMAN :- Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
- Belongs to the calreticulin family.
- Domain:
-
- Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
- The interaction with glycans occurs through a binding site in the globular lectin domain.
- The zinc binding sites are localized to the N-domain.
- Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
- Family:
-
- Belongs to the calreticulin family.
Function for CALR Gene
Molecular function for CALR Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
- GENATLAS Biochemistry:
- calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa
Phenotypes From GWAS Catalog for CALR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001849 | complement component C1q binding | TAS | 15474971 |
| GO:0003677 | DNA binding | NAS | 11149926 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003729 | mRNA binding | IDA | 14726956 |
| GO:0005178 | integrin binding | IPI | 1911778 |
Phenotypes for CALR Gene
- MGI mutant phenotypes for CALR:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CALR:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CALR - Select products 50% OFF >
- * CALR CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CALR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALR
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALR
miRNA for CALR Gene
- miRTarBase miRNAs that target CALR
-
- mmu-miR-149-5p (MIRT014748)
- hsa-miR-124-3p (MIRT022337)
- hsa-miR-122-5p (MIRT023227)
- hsa-miR-1-3p (MIRT023576)
- hsa-miR-16-5p (MIRT031457)
- hsa-miR-423-3p (MIRT042481)
- hsa-miR-320a (MIRT044537)
- hsa-miR-149-5p (MIRT045548)
- bta-miR-31 (MIRT053894)
- bta-miR-181a (MIRT053976)
- hsa-miR-148a-5p (MIRT081250)
- hsa-miR-516a-5p (MIRT081252)
- hsa-miR-875-3p (MIRT081253)
- hsa-miR-1254 (MIRT081254)
- hsa-miR-3116 (MIRT081255)
- hsa-miR-3148 (MIRT081256)
- hsa-miR-3646 (MIRT081257)
- hsa-miR-3662 (MIRT081258)
- hsa-miR-6849-3p (MIRT081259)
- hsa-miR-6782-5p (MIRT399345)
- hsa-miR-412-3p (MIRT441024)
- hsa-miR-6783-3p (MIRT480077)
- hsa-miR-1343-3p (MIRT480078)
- hsa-miR-6848-5p (MIRT480079)
- hsa-miR-6846-5p (MIRT480080)
- hsa-miR-4697-5p (MIRT480081)
- hsa-miR-4488 (MIRT480082)
- hsa-miR-1237-5p (MIRT480083)
- hsa-miR-486-3p (MIRT480084)
- hsa-miR-6721-5p (MIRT480085)
- hsa-miR-6878-5p (MIRT480086)
- hsa-miR-4763-3p (MIRT480087)
- hsa-miR-1207-5p (MIRT480088)
- hsa-miR-6722-3p (MIRT480089)
- hsa-miR-1909-3p (MIRT480090)
- hsa-miR-6738-5p (MIRT480091)
- hsa-miR-5194 (MIRT480092)
- hsa-miR-1914-3p (MIRT480093)
- hsa-miR-1225-3p (MIRT480094)
- hsa-miR-1253 (MIRT480095)
- hsa-miR-3179 (MIRT480096)
- hsa-miR-203a-3p (MIRT480097)
- hsa-miR-5681a (MIRT480098)
- hsa-miR-6742-3p (MIRT480099)
- hsa-miR-637 (MIRT480100)
- hsa-miR-6852-5p (MIRT480101)
- hsa-miR-939-3p (MIRT480102)
- hsa-miR-1910-5p (MIRT480103)
- hsa-miR-6838-3p (MIRT480104)
- hsa-miR-4756-5p (MIRT480105)
- hsa-miR-4739 (MIRT480106)
- hsa-miR-1321 (MIRT480107)
- hsa-miR-5197-3p (MIRT480108)
- hsa-miR-1252-3p (MIRT480109)
- hsa-miR-4533 (MIRT480110)
- hsa-miR-4518 (MIRT480111)
- hsa-miR-4468 (MIRT480112)
- hsa-miR-1266-5p (MIRT480113)
- hsa-miR-3664-3p (MIRT480114)
- hsa-miR-1245b-3p (MIRT480115)
- hsa-miR-6876-5p (MIRT480116)
- hsa-miR-4476 (MIRT480117)
- hsa-miR-2278 (MIRT480118)
- hsa-miR-4428 (MIRT480119)
- hsa-miR-665 (MIRT480120)
- hsa-miR-216a-5p (MIRT480121)
- hsa-miR-4534 (MIRT480122)
- hsa-miR-4665-5p (MIRT480123)
- hsa-miR-1275 (MIRT480124)
- hsa-miR-4472 (MIRT480125)
- hsa-miR-7847-3p (MIRT480126)
- hsa-miR-4447 (MIRT480127)
- hsa-miR-92a-2-5p (MIRT480128)
- hsa-miR-6766-5p (MIRT480129)
- hsa-miR-6756-5p (MIRT480130)
- hsa-miR-608 (MIRT480131)
- hsa-miR-4651 (MIRT480132)
- hsa-miR-7110-5p (MIRT480133)
- hsa-miR-6842-5p (MIRT480134)
- hsa-miR-6752-5p (MIRT480135)
- hsa-miR-5010-5p (MIRT480136)
- hsa-miR-4525 (MIRT480137)
- hsa-miR-6870-5p (MIRT480138)
- hsa-miR-7111-5p (MIRT480139)
- hsa-miR-5698 (MIRT480140)
- hsa-miR-4723-5p (MIRT480141)
- hsa-miR-625-5p (MIRT480142)
- hsa-miR-6825-5p (MIRT480143)
- hsa-miR-3175 (MIRT480144)
- hsa-miR-6883-5p (MIRT480145)
- hsa-miR-6785-5p (MIRT480146)
- hsa-miR-4728-5p (MIRT480147)
- hsa-miR-149-3p (MIRT480148)
- hsa-miR-8085 (MIRT480149)
- hsa-miR-6787-5p (MIRT480150)
- hsa-miR-6731-5p (MIRT480151)
- hsa-miR-663a (MIRT480152)
- hsa-miR-1908-5p (MIRT480153)
- hsa-miR-6894-5p (MIRT480154)
- hsa-miR-765 (MIRT480155)
- hsa-miR-7154-3p (MIRT480156)
- hsa-miR-766-5p (MIRT480157)
- hsa-miR-5192 (MIRT480158)
- hsa-miR-4749-5p (MIRT480159)
- hsa-miR-4706 (MIRT480160)
- hsa-miR-4693-3p (MIRT480161)
- hsa-miR-6889-5p (MIRT480162)
- hsa-miR-6777-5p (MIRT480163)
- hsa-miR-6732-5p (MIRT480164)
- hsa-miR-6783-5p (MIRT480165)
- hsa-miR-4779 (MIRT480166)
- hsa-miR-3141 (MIRT480167)
- hsa-miR-6124 (MIRT512182)
- hsa-miR-342-3p (MIRT524562)
- hsa-miR-6716-3p (MIRT558968)
- hsa-miR-6771-3p (MIRT723641)
- mmu-miR-455-5p (MIRT734948)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALR
- Browse OriGene Inhibitory RNA Products For CALR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALR
Clone Products
- Applied Biological Materials (abm): Clones for CALR - Select products 50% OFF >
- * CALR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CALR
- Addgene plasmids for CALR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALR
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CALR Gene
Localization for CALR Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALR Gene
- Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). Associated with the lytic granules in the cytolytic T-lymphocytes. {ECO:0000269 PubMed:10358038, ECO:0000269 PubMed:8418194}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| endosome | 2 |
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001669 | acrosomal vesicle | IEA | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IMP | 22377355 |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 8107809 |
Pathways & Interactions for CALR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Antigen processing-Cross presentation |
Immune response Antigen presentation by MHC class I
.51
|
|
| 2 | Unfolded Protein Response (UPR) | ||
| 3 | Binding and Uptake of Ligands by Scavenger Receptors | ||
| 4 | Human cytomegalovirus infection | ||
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for CALR Gene
3 BioSystems pathways for CALR Gene
24 Reactome pathways for CALR Gene
2 GeneGo (Thomson Reuters) pathways for CALR Gene
- Immune response Antigen presentation by MHC class I
- Transcription_Role of VDR in regulation of genes involved in osteoporosis
2 Qiagen pathways for CALR Gene
- Androgen Signaling
- Presenilin-Mediated Signaling
2 Cell Signaling Technology pathways for CALR Gene
Interacting Proteins for CALR Gene
Selected Interacting proteins:
P27797-CALR_HUMAN
ENSP00000320866
for CALR Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CALR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 8107809 |
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0002502 | peptide antigen assembly with MHC class I protein complex | ISS | 11825569 |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 8107808 |
No data available for SIGNOR curated interactions for CALR Gene
Drugs & Compounds for CALR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Melatonin | Approved, Vet_approved | Nutra | Antagonist, Agonist, Full agonist, Target | Melatonin receptors MT inhibitor, Endogenous hormone; agonist at MT1 and MT2 | 398 | |
| Antihemophilic factor, human recombinant | Approved, Investigational | Pharma | Target, chaperone | 0 | ||
| Calcium citrate | Approved, Investigational | Pharma | Target, ligand | 0 | ||
| Calcium Phosphate | Approved | Pharma | Target, ligand | 0 | ||
| Calcium phosphate dihydrate | Approved | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CALR Gene
mRNA/cDNA for CALR Gene
- 1 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000587486 957 nts (view in UCSC)
- ENST00000316448 1901 nts (view in UCSC)
- ENST00000590325 781 nts (view in UCSC)
- ENST00000588454 776 nts (view in UCSC)
- ENST00000586760 913 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CALR - Select products 50% OFF >
- * CALR CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CALR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALR
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALR
- Browse OriGene Inhibitory RNA Products For CALR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALR
Clone Products
- Applied Biological Materials (abm): Clones for CALR - Select products 50% OFF >
- * CALR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CALR
- Addgene plasmids for CALR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALR
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: |
Relevant External Links for CALR Gene
- GeneLoc Exon Structure for
- CALR
Expression for CALR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Cardiovascular System)
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CALR Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALR
SOURCE GeneReport for Unigene cluster for CALR Gene:
Hs.515162Evidence on tissue expression from TISSUES for CALR Gene
- Nervous system(4.9)
- Skin(4.9)
- Eye(4.9)
- Pancreas(4.9)
- Liver(4.8)
- Lung(4.7)
- Intestine(4.5)
- Kidney(4.4)
- Spleen(4)
- Heart(3.9)
- Blood(3.9)
- Stomach(3.8)
- Bone marrow(3.8)
- Lymph node(3.7)
- Muscle(3.7)
- Thyroid gland(3.5)
- Bone(3.5)
- Adrenal gland(3)
- Gall bladder(2.6)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CALR Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- ear
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- liver
- spleen
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CALR
-
OriGene qPCR primer pairs and template standards for CALR
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALR Gene
Orthologs for CALR Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CALR 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CALR 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CALR 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Calr 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Calr 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CALR 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CALR 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CALR 31 |
|
OneToOne | |
| CALR3 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | CALR 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | calr 30 |
|
||
| Str.538 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | calr-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | calrl2 30 31 |
|
OneToOne | |
| calr 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9141 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Crc 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004212 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | crt-1 30 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CNE1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CRT1b 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1564 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os07g0246200 30 |
|
||
| Os.7158 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.1770 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.1288 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10660 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3623 30 |
|
- Species where no ortholog for CALR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CALR Gene
- ENSEMBL:
- Gene Tree for CALR (if available)
- TreeFam:
- Gene Tree for CALR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CALR: view image
Paralogs for CALR Gene
Variants for CALR Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALR Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708616 | Benign: not provided | 12,940,356(+) | C/T | SYNONYMOUS_VARIANT | |
| 741199 | Likely Benign: not provided | 12,940,257(+) | A/T | SYNONYMOUS_VARIANT | |
| 761698 | Likely Benign: not provided | 12,939,465(+) | G/T | SYNONYMOUS_VARIANT | |
| 764942 | Benign: not provided | 12,939,212(+) | A/G | MISSENSE_VARIANT | |
| 771513 | Benign: not provided | 12,943,801(+) | A/C | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.89;
35.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CALR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALR Gene
Disorders for CALR Gene
(52) MalaCards diseases for CALR Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myelofibrosis |
|
|
| thrombocythemia 1 |
|
|
| essential thrombocythemia |
|
|
| rubella |
|
|
| heart block, congenital |
|
Search CALR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CALR_HUMAN- Note=CARL somatic mutations are frequently found in myeloproliferative neoplasms lacking JAK2 or MPL mutations. Myeloproliferative neoplasms are chronic myeloid cancers characterized by overproduction of mature blood cells, and may evolve into acute myeloid leukemia. In addition to chronic myeloid leukemia with the BCR-ABL fusion gene, the three most common myeloproliferative neoplasms are essential thrombocythemia, polycythemia vera, and myelofibrosis. {ECO:0000269 PubMed:24325356, ECO:0000269 PubMed:24325359}.
Additional Disease Information for CALR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for CALR Gene
Publications for CALR Gene
- Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. (PMID: 10358038) Arosa FA … de Sousa M (The Journal of biological chemistry 1999) 3 4 23
- TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. (PMID: 9427624) Braud VM … McMichael AJ (Current biology : CB 1998) 3 4 23
- Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo. (PMID: 9640257) Wainwright SD … Holmes CH (Immunology 1998) 3 4 23
- Human placental calreticulin: purification, characterization and association with other proteins. (PMID: 7841019) Houen G … Koch C (Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1994) 3 4 23
- The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. (PMID: 8418194) Dupuis M … Tschopp J (The Journal of experimental medicine 1993) 3 4 23
ExternalLinks
Products for CALR Gene
- OriGene Antibodies for CALR