Aliases for CALML6 Gene

Aliases for CALML6 Gene

  • Calmodulin Like 6 2 3 5
  • CAGLP 2 3 4
  • Calmodulin-Like Protein 6 3 4
  • Calglandulin-Like Protein 3 4
  • Calmodulin-Like 6 2
  • EF-Hand Protein 3
  • CALML6 5
  • CALGP 4

External Ids for CALML6 Gene

Previous GeneCards Identifiers for CALML6 Gene

  • GC01P001880
  • GC01P001126
  • GC01P001914

Summaries for CALML6 Gene

GeneCards Summary for CALML6 Gene

CALML6 (Calmodulin Like 6) is a Protein Coding gene. Diseases associated with CALML6 include Chromosome 1P36 Deletion Syndrome. Among its related pathways are Apelin signaling pathway and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALM1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALML6 Gene

Genomics for CALML6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CALML6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALML6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALML6

Top Transcription factor binding sites by QIAGEN in the CALML6 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E47
  • Ik-2
  • Lmo2
  • Sp1

Genomic Locations for CALML6 Gene

Latest Assembly
3,546 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,037 bases
Plus strand

(GRCh37/hg19 by Ensembl)
2,470 bases
Plus strand

Genomic View for CALML6 Gene

Genes around CALML6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML6 Gene

Proteins for CALML6 Gene

  • Protein details for CALML6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calmodulin-like protein 6
    Protein Accession:
    Secondary Accessions:
    • A2A2M3
    • Q6Q2C4

    Protein attributes for CALML6 Gene

    181 amino acids
    Molecular mass:
    20690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALML6 Gene

Post-translational modifications for CALML6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML6 Gene

No data available for DME Specific Peptides for CALML6 Gene

Domains & Families for CALML6 Gene

Gene Families for CALML6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CALML6 Gene

Suggested Antigen Peptide Sequences for CALML6 Gene

GenScript: Design optimal peptide antigens:
  • Calglandulin-like protein (CALL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calmodulin family. Calglandulin subfamily.
  • Belongs to the calmodulin family. Calglandulin subfamily.
genes like me logo Genes that share domains with CALML6: view

Function for CALML6 Gene

Phenotypes From GWAS Catalog for CALML6 Gene

Gene Ontology (GO) - Molecular Function for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0030234 enzyme regulator activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CALML6: view

Phenotypes for CALML6 Gene

genes like me logo Genes that share phenotypes with CALML6: view

miRNA for CALML6 Gene

miRTarBase miRNAs that target CALML6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALML6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML6 Gene

Localization for CALML6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALML6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALML6 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CALML6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALML6 Gene

Pathways & Interactions for CALML6 Gene

genes like me logo Genes that share pathways with CALML6: view

Gene Ontology (GO) - Biological Process for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0019722 calcium-mediated signaling IBA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with CALML6: view

No data available for SIGNOR curated interactions for CALML6 Gene

Drugs & Compounds for CALML6 Gene

No Compound Related Data Available

Transcripts for CALML6 Gene

mRNA/cDNA for CALML6 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALML6

Alternative Splicing Database (ASD) splice patterns (SP) for CALML6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP2: -

Relevant External Links for CALML6 Gene

GeneLoc Exon Structure for

Expression for CALML6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CALML6 Gene

mRNA differential expression in normal tissues according to GTEx for CALML6 Gene

This gene is overexpressed in Muscle - Skeletal (x17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALML6 Gene

Protein tissue co-expression partners for CALML6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALML6

SOURCE GeneReport for Unigene cluster for CALML6 Gene:


mRNA Expression by UniProt/SwissProt for CALML6 Gene:

Tissue specificity: Expressed in prostate, thymus, heart, skeleton muscle, bone marrow and ovary.

Evidence on tissue expression from TISSUES for CALML6 Gene

  • Muscle(4.5)
genes like me logo Genes that share expression patterns with CALML6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALML6 Gene

Orthologs for CALML6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALML6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALML6 29 30
  • 98.34 (n)
(Canis familiaris)
Mammalia CALML6 29 30
  • 85.27 (n)
(Bos Taurus)
Mammalia CALML6 30
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CALML6 30
  • 53 (a)
(Danio rerio)
Actinopterygii calml4b 30
  • 28 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG17770 30
  • 32 (a)
CG5024 30
  • 28 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4307 30
  • 44 (a)
Species where no ortholog for CALML6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CALML6 Gene

Gene Tree for CALML6 (if available)
Gene Tree for CALML6 (if available)
Evolutionary constrained regions (ECRs) for CALML6: view image
Alliance of Genome Resources:
Additional Orthologs for CALML6

Paralogs for CALML6 Gene

(20) SIMAP similar genes for CALML6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALML6: view

Variants for CALML6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALML6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs35804144 Benign: not provided 1,916,569(+) C/T
NM_138705.4(CALML6):c.207C>T (p.Pro69=)
rs35971167 Benign: not provided 1,916,786(+) A/G
NM_138705.4(CALML6):c.288A>G (p.Ala96=)
rs74773083 Benign: not provided 1,916,758(+) G/C
NM_138705.4(CALML6):c.260G>C (p.Gly87Ala)
rs28581776 -- p.Trp60Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CALML6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CALML6 Gene

Variant ID Type Subtype PubMed ID
esv2758913 CNV gain+loss 17122850
nsv10383 CNV gain 18304495
nsv482937 CNV loss 15286789
nsv834335 CNV loss 17160897
nsv951400 CNV deletion 24416366

Variation tolerance for CALML6 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALML6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML6 Gene

Disorders for CALML6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CALML6 Gene - From: COP

Disorder Aliases PubMed IDs
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CALML6

genes like me logo Genes that share disorders with CALML6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALML6 Gene

Publications for CALML6 Gene

  1. Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein. (PMID: 15621662) Chen S … Yu L (DNA sequence : the journal of DNA sequencing and mapping 2004) 3 4 22
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. (PMID: 31753913) Kim JJ … Miller KM (Genes & development 2019) 3
  5. The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. (PMID: 30699354) Wang Z … Chen S (Cell reports 2019) 3

Products for CALML6 Gene

Sources for CALML6 Gene