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Aliases for CALML6 Gene

Aliases for CALML6 Gene

  • Calmodulin Like 6 2 3 5
  • Calglandulin-Like Protein 3 4
  • CAGLP 3 4
  • Calmodulin-Like Protein 6 3
  • Calmodulin-Like 6 2
  • EF-Hand Protein 3
  • CALGP 4

External Ids for CALML6 Gene

Previous GeneCards Identifiers for CALML6 Gene

  • GC01P001880
  • GC01P001126

Summaries for CALML6 Gene

GeneCards Summary for CALML6 Gene

CALML6 (Calmodulin Like 6) is a Protein Coding gene. Among its related pathways are Apelin signaling pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALM2.

Additional gene information for CALML6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML6 Gene

Genomics for CALML6 Gene

GeneHancer (GH) Regulatory Elements for CALML6 Gene

Promoters and enhancers for CALML6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001888 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 15.6 -20.7 -20743 9.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 GC01M001889 GNB1 ATAD3B LOC105378949 CCNL2 LOC100288379 INTS11 ENSG00000240731 PUSL1 LOC100129381
GH01J001913 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 14.1 +3.8 3822 7.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF143 SP3 SP5 TMEM52 LOC105378949 CALML6 CFAP74 LOC105378589 GABRD
GH01J001906 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17 -5.6 -5565 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LOC105378949 INTS11 ENSG00000240731 CALML6 CCNL2 CDK11A LOC100288379 C1orf159 TMEM52 NOC2L
GH01J001775 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -134.2 -134226 8.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 NADK INTS11 CCNL2 CDK11A ATAD3B ENSG00000230092 ENSG00000240731 FAAP20 LOC100288379 LINC00115
GH01J001942 Enhancer 1.2 Ensembl ENCODE 16.5 +29.8 29809 2.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 TMEM52 LOC105378949 CALML6 GC01P001930 PIR58366 CFAP74
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALML6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALML6 gene promoter:
  • AP-1
  • Sp1
  • c-Jun
  • ATF-2
  • Ik-2
  • E47
  • Lmo2

Genomic Locations for CALML6 Gene

Genomic Locations for CALML6 Gene
3,545 bases
Plus strand
2,470 bases
Plus strand

Genomic View for CALML6 Gene

Genes around CALML6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML6 Gene

Proteins for CALML6 Gene

  • Protein details for CALML6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calmodulin-like protein 6
    Protein Accession:
    Secondary Accessions:
    • A2A2M3
    • Q6Q2C4

    Protein attributes for CALML6 Gene

    181 amino acids
    Molecular mass:
    20690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALML6 Gene

Post-translational modifications for CALML6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML6 Gene

No data available for DME Specific Peptides for CALML6 Gene

Domains & Families for CALML6 Gene

Gene Families for CALML6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CALML6 Gene

Suggested Antigen Peptide Sequences for CALML6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calmodulin family. Calglandulin subfamily.
  • Belongs to the calmodulin family. Calglandulin subfamily.
genes like me logo Genes that share domains with CALML6: view

Function for CALML6 Gene

Phenotypes From GWAS Catalog for CALML6 Gene

Gene Ontology (GO) - Molecular Function for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CALML6: view
genes like me logo Genes that share phenotypes with CALML6: view

Animal Model Products

miRNA for CALML6 Gene

miRTarBase miRNAs that target CALML6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML6 Gene

Localization for CALML6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALML6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALML6 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CALML6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALML6 Gene

Pathways & Interactions for CALML6 Gene

genes like me logo Genes that share pathways with CALML6: view

Gene Ontology (GO) - Biological Process for CALML6 Gene


No data available for SIGNOR curated interactions for CALML6 Gene

Drugs & Compounds for CALML6 Gene

No Compound Related Data Available

Transcripts for CALML6 Gene

mRNA/cDNA for CALML6 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML6 Gene

Calmodulin-like 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALML6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP2: -

Relevant External Links for CALML6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALML6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALML6 Gene

mRNA differential expression in normal tissues according to GTEx for CALML6 Gene

This gene is overexpressed in Muscle - Skeletal (x17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALML6 Gene

Protein tissue co-expression partners for CALML6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CALML6 Gene:


SOURCE GeneReport for Unigene cluster for CALML6 Gene:


mRNA Expression by UniProt/SwissProt for CALML6 Gene:

Tissue specificity: Expressed in prostate, thymus, heart, skeleton muscle, bone marrow and ovary.

Evidence on tissue expression from TISSUES for CALML6 Gene

  • Muscle(4.4)
genes like me logo Genes that share expression patterns with CALML6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALML6 Gene

Orthologs for CALML6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALML6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALML6 34 33
  • 98.34 (n)
(Canis familiaris)
Mammalia CALML6 34 33
  • 85.27 (n)
(Bos Taurus)
Mammalia CALML6 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CALML6 34
  • 53 (a)
(Danio rerio)
Actinopterygii calml4b 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17770 34
  • 32 (a)
CG5024 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4307 34
  • 44 (a)
Species where no ortholog for CALML6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALML6 Gene

Gene Tree for CALML6 (if available)
Gene Tree for CALML6 (if available)
Evolutionary constrained regions (ECRs) for CALML6: view image

Paralogs for CALML6 Gene

Paralogs for CALML6 Gene

(20) SIMAP similar genes for CALML6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALML6: view

Variants for CALML6 Gene

Sequence variations from dbSNP and Humsavar for CALML6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000816459 -- 1,915,394(+) A/G intron_variant
rs1001102779 -- 1,914,099(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001165328 -- 1,917,354(+) G/C downstream_transcript_variant
rs1001214542 -- 1,917,613(+) C/T downstream_transcript_variant
rs1001913530 -- 1,913,984(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CALML6 Gene

Variant ID Type Subtype PubMed ID
esv2758913 CNV gain+loss 17122850
nsv10383 CNV gain 18304495
nsv482937 CNV loss 15286789
nsv834335 CNV loss 17160897
nsv951400 CNV deletion 24416366

Variation tolerance for CALML6 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALML6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML6 Gene

Disorders for CALML6 Gene

Additional Disease Information for CALML6

No disorders were found for CALML6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALML6 Gene

Publications for CALML6 Gene

  1. Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein. (PMID: 15621662) Chen S … Yu L (DNA sequence : the journal of DNA sequencing and mapping 2004) 3 4 22 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. (PMID: 19294699) Chiarini A … Dal Pra I (Proteomics 2009) 3 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CALML6 Gene

Sources for CALML6 Gene

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