This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating kera... See more...

Aliases for CALML5 Gene

Aliases for CALML5 Gene

  • Calmodulin Like 5 2 3 5
  • Calmodulin-Like Skin Protein 2 3 4
  • Calmodulin-Like Protein 5 3 4
  • CLSP 3 4
  • Calmodulin-Like 5 2

External Ids for CALML5 Gene

Previous GeneCards Identifiers for CALML5 Gene

  • GC10M005494
  • GC10M005530

Summaries for CALML5 Gene

Entrez Gene Summary for CALML5 Gene

  • This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALML5 Gene

CALML5 (Calmodulin Like 5) is a Protein Coding gene. Diseases associated with CALML5 include Alzheimer Disease. Among its related pathways are Oxytocin signaling pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALM3.

UniProtKB/Swiss-Prot Summary for CALML5 Gene

  • Binds calcium. May be involved in terminal differentiation of keratinocytes.

Gene Wiki entry for CALML5 Gene

Additional gene information for CALML5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALML5 Gene

Genomics for CALML5 Gene

GeneHancer (GH) Regulatory Elements for CALML5 Gene

Promoters and enhancers for CALML5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J005499 Enhancer 0.6 Ensembl dbSUPER 500.7 +0.1 69 1 MAZ ZBTB7B ZBTB33 ZNF687 MTA1 ZHX2 CALML5 CALML3 lnc-CALML5-8
GH10J005500 Enhancer 0.5 Ensembl dbSUPER 500.7 -1.5 -1531 0.2 ZNF341 RAD21 CALML5 ENSG00000256462 CALML3 CALML3-AS1 piR-30868
GH10J005444 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +51.7 51747 7.2 NRF1 TCF12 MYC USF1 POLR2G NCOR1 GTF2E2 EP300 ZIC2 POLR2A NET1 TUBAL3 AKR1E2 CALML5 CALML3 CALML3-AS1 ENSG00000256462 ASB13 NRBF2P5 UCN3
GH10J005476 Enhancer 1.3 Ensembl ENCODE dbSUPER 19 +21.1 21070 6.2 PHB2 ZBTB11 AFF1 TARDBP MYC CTBP1 TRIM25 HINFP TAF9B HDAC3 CALML5 CALML3-AS1 ENSG00000256462 CALML3 ASB13 TUBAL3 piR-37567-017 piR-30444-030 lnc-CALML5-8
GH10J005581 Enhancer 1.6 VISTA Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -87.6 -87630 11.2 ZNF217 CTCF TCF12 SP1 FOS EP300 ZIC2 REST KLF4 RFX1 CALML5 CALML3 CALML3-AS1 ENSG00000256462 LINC02657 ASB13 NET1 LINC02677 HSALNG0075875 LINC02678
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALML5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALML5

Top Transcription factor binding sites by QIAGEN in the CALML5 gene promoter:
  • CUTL1
  • GATA-2
  • HSF2
  • LCR-F1
  • p53
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT5A

Genomic Locations for CALML5 Gene

Genomic Locations for CALML5 Gene
chr10:5,498,695-5,499,570
(GRCh38/hg38)
Size:
876 bases
Orientation:
Minus strand
chr10:5,540,658-5,541,533
(GRCh37/hg19)
Size:
876 bases
Orientation:
Minus strand

Genomic View for CALML5 Gene

Genes around CALML5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML5 Gene

Proteins for CALML5 Gene

  • Protein details for CALML5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZT1-CALL5_HUMAN
    Recommended name:
    Calmodulin-like protein 5
    Protein Accession:
    Q9NZT1
    Secondary Accessions:
    • Q5SQI3
    • Q8IXU8

    Protein attributes for CALML5 Gene

    Size:
    146 amino acids
    Molecular mass:
    15893 Da
    Quaternary structure:
    • Associates with transglutaminase 3.

    Three dimensional structures from OCA and Proteopedia for CALML5 Gene

neXtProt entry for CALML5 Gene

Post-translational modifications for CALML5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALML5 Gene

Domains & Families for CALML5 Gene

Gene Families for CALML5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CALML5 Gene

Suggested Antigen Peptide Sequences for CALML5 Gene

GenScript: Design optimal peptide antigens:
  • Calmodulin-like skin protein (CALL5_HUMAN)
genes like me logo Genes that share domains with CALML5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CALML5 Gene

Function for CALML5 Gene

Molecular function for CALML5 Gene

UniProtKB/Swiss-Prot Function:
Binds calcium. May be involved in terminal differentiation of keratinocytes.

Phenotypes From GWAS Catalog for CALML5 Gene

Gene Ontology (GO) - Molecular Function for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CALML5: view
genes like me logo Genes that share phenotypes with CALML5: view

Animal Model Products

CRISPR Products

miRNA for CALML5 Gene

miRTarBase miRNAs that target CALML5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALML5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML5 Gene

Localization for CALML5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALML5 gene
Compartment Confidence
extracellular 4
cytosol 4
nucleus 3
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with CALML5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CALML5 Gene

Pathways & Interactions for CALML5 Gene

genes like me logo Genes that share pathways with CALML5: view

Pathways by source for CALML5 Gene

Gene Ontology (GO) - Biological Process for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10777582
GO:0008544 epidermis development TAS 10777582
GO:0019722 calcium-mediated signaling IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CALML5: view

No data available for SIGNOR curated interactions for CALML5 Gene

Drugs & Compounds for CALML5 Gene

(1) Drugs for CALML5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with CALML5: view

Transcripts for CALML5 Gene

mRNA/cDNA for CALML5 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALML5

Alternative Splicing Database (ASD) splice patterns (SP) for CALML5 Gene

No ASD Table

Relevant External Links for CALML5 Gene

GeneLoc Exon Structure for
CALML5

Expression for CALML5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CALML5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALML5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.1) and Skin - Not Sun Exposed (Suprapubic) (x20.8).

Protein differential expression in normal tissues from HIPED for CALML5 Gene

This gene is overexpressed in Salivary gland (15.9), Skin (11.7), Cervix (11.1), and Urinary Bladder (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CALML5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALML5

SOURCE GeneReport for Unigene cluster for CALML5 Gene:

Hs.180142

mRNA Expression by UniProt/SwissProt for CALML5 Gene:

Q9NZT1-CALL5_HUMAN
Tissue specificity: Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Evidence on tissue expression from TISSUES for CALML5 Gene

  • Skin(4.6)
  • Liver(4)
genes like me logo Genes that share expression patterns with CALML5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALML5 Gene

Orthologs for CALML5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CALML5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALML5 31 30
  • 98.17 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CALML5 31 30
  • 76.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CALML5 31 30
  • 72.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calml5 30
  • 64.84 (n)
mouse
(Mus musculus)
Mammalia Calm4 17 30
  • 63.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CALML5 31
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tnnc1b 31
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31960 31
  • 39 (a)
ManyToMany
CG11165 31
  • 35 (a)
ManyToMany
CG31958 31
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cal-2 31
  • 36 (a)
ManyToMany
cal-1 31
  • 36 (a)
ManyToMany
cal-4 31
  • 25 (a)
ManyToMany
cal-3 31
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 31
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7047 31
  • 34 (a)
ManyToMany
Species where no ortholog for CALML5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CALML5 Gene

ENSEMBL:
Gene Tree for CALML5 (if available)
TreeFam:
Gene Tree for CALML5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CALML5: view image

Paralogs for CALML5 Gene

(24) SIMAP similar genes for CALML5 Gene using alignment to 1 proteins:

  • CALL5_HUMAN
genes like me logo Genes that share paralogs with CALML5: view

Variants for CALML5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALML5 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10904516 - p.Lys74Arg
rs11546426 - p.Ser58Gly

Additional dbSNP identifiers (rs#s) for CALML5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CALML5 Gene

Variant ID Type Subtype PubMed ID
nsv1051283 CNV gain 25217958
nsv549886 CNV loss 21841781
nsv831774 CNV gain 17160897

Variation tolerance for CALML5 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALML5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALML5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML5 Gene

Disorders for CALML5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CALML5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CALML5

genes like me logo Genes that share disorders with CALML5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALML5 Gene

Publications for CALML5 Gene

  1. Identification and cloning of a new calmodulin-like protein from human epidermis. (PMID: 10777582) Méhul B … Schmidt R (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. A structural and dynamic characterization of the EF-hand protein CLSP. (PMID: 16765896) Babini E … Luchinat C (Structure (London, England : 1993) 2006) 3 4 23 54
  3. Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. (PMID: 16689864) Méhul B … Schmidt R (Experimental dermatology 2006) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Podocalyxin-like protein promotes gastric cancer progression through interacting with RUN and FYVE domain containing 1 protein. (PMID: 30407695) Zhi Q … Zhou J (Cancer science 2019) 3 54

Products for CALML5 Gene

Sources for CALML5 Gene