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Aliases for CALML4 Gene

Aliases for CALML4 Gene

  • Calmodulin Like 4 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-20 3 4
  • Calmodulin-Like Protein 4 3
  • Calmodulin-Like 4 2
  • NY-BR-20 3

External Ids for CALML4 Gene

Previous GeneCards Identifiers for CALML4 Gene

  • GC15M066198
  • GC15M066270
  • GC15M068483
  • GC15M045313

Summaries for CALML4 Gene

GeneCards Summary for CALML4 Gene

CALML4 (Calmodulin Like 4) is a Protein Coding gene. Among its related pathways are Salivary secretion and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALM3.

Additional gene information for CALML4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML4 Gene

Genomics for CALML4 Gene

GeneHancer (GH) Regulatory Elements for CALML4 Gene

Promoters and enhancers for CALML4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I068203 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 409 4.2 HDAC1 ATF1 ARNT ARID4B ZBTB40 RAD21 YY1 SCRT2 ETV6 CREM CALML4 CLN6 LOC105370871 ENSG00000260007
GH15I067913 Enhancer 1.4 FANTOM5 Ensembl ENCODE 18.9 +289.6 289632 5.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF280A CALML4 PIAS1 CLN6 IQCH GC15M067974 GC15M067840 RNU6-1
GH15I067850 Enhancer 1 Ensembl ENCODE 11.1 +354.8 354815 1.4 HDGF ELF3 BATF ZNF335 ETV6 FOS IKZF2 ZNF362 SMARCC1 CEBPB CALML4 IQCH-AS1 PIAS1 GC15M067840 RNU6-1 ENSG00000259410 GC15M067974
GH15I068232 Enhancer 0.8 Ensembl ENCODE 12.1 -27.0 -27032 1.6 ELF3 SAP130 HMG20A ZNF645 ZNF644 RARA ZGPAT KLF16 SMAD4 HNF4A CLN6 CALML4 ENSG00000260007 HMGN2P40
GH15I067880 Enhancer 1.5 FANTOM5 Ensembl ENCODE 5.5 +322.8 322848 5.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT SIN3A FEZF1 DMAP1 SKOR1 PIAS1 IQCH-AS1 RNU6-1 LOC101929076 MAP2K5 CALML4 FEM1B GC15M067840 GC15M067974
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALML4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALML4 gene promoter:

Genomic Locations for CALML4 Gene

Genomic Locations for CALML4 Gene
chr15:68,190,705-68,206,110
(GRCh38/hg38)
Size:
15,406 bases
Orientation:
Minus strand
chr15:68,483,043-68,498,448
(GRCh37/hg19)

Genomic View for CALML4 Gene

Genes around CALML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML4 Gene

Proteins for CALML4 Gene

  • Protein details for CALML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GE6-CALL4_HUMAN
    Recommended name:
    Calmodulin-like protein 4
    Protein Accession:
    Q96GE6
    Secondary Accessions:
    • B4DL15
    • F8W6Y4
    • Q6MZY3
    • Q6N048
    • Q9H286

    Protein attributes for CALML4 Gene

    Size:
    196 amino acids
    Molecular mass:
    21883 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG48255.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAG59377.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CALML4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALML4 Gene

Post-translational modifications for CALML4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CALML4 Gene

Domains & Families for CALML4 Gene

Gene Families for CALML4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CALML4 Gene

Suggested Antigen Peptide Sequences for CALML4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GE6

UniProtKB/Swiss-Prot:

CALL4_HUMAN :
  • Belongs to the calmodulin family.
Family:
  • Belongs to the calmodulin family.
genes like me logo Genes that share domains with CALML4: view

Function for CALML4 Gene

Gene Ontology (GO) - Molecular Function for CALML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CALML4: view
genes like me logo Genes that share phenotypes with CALML4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML4 Gene

Localization for CALML4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALML4 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CALML4 Gene

Pathways & Interactions for CALML4 Gene

genes like me logo Genes that share pathways with CALML4: view

Gene Ontology (GO) - Biological Process for CALML4 Gene

None

No data available for SIGNOR curated interactions for CALML4 Gene

Drugs & Compounds for CALML4 Gene

No Compound Related Data Available

Transcripts for CALML4 Gene

Unigene Clusters for CALML4 Gene

Calmodulin-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALML4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for CALML4 Gene

GeneLoc Exon Structure for
CALML4
ECgene alternative splicing isoforms for
CALML4

Expression for CALML4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALML4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALML4 Gene

This gene is overexpressed in Colon - Transverse (x8.0).

Protein differential expression in normal tissues from HIPED for CALML4 Gene

This gene is overexpressed in Plasma (27.3), Fetal gut (10.3), Liver (7.9), and Prostate (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALML4 Gene



NURSA nuclear receptor signaling pathways regulating expression of CALML4 Gene:

CALML4

SOURCE GeneReport for Unigene cluster for CALML4 Gene:

Hs.709550

mRNA Expression by UniProt/SwissProt for CALML4 Gene:

Q96GE6-CALL4_HUMAN
Tissue specificity: Expressed in breast cancer cell lines.

Evidence on tissue expression from TISSUES for CALML4 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with CALML4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALML4 Gene

Orthologs for CALML4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALML4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALML4 33 34
  • 98.81 (n)
cow
(Bos Taurus)
Mammalia CALML4 33 34
  • 88.45 (n)
dog
(Canis familiaris)
Mammalia CALML4 33 34
  • 87.3 (n)
mouse
(Mus musculus)
Mammalia Calml4 33 16 34
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Calml4 33
  • 85.4 (n)
oppossum
(Monodelphis domestica)
Mammalia CALML4 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALML4 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALML4 33 34
  • 68.85 (n)
lizard
(Anolis carolinensis)
Reptilia CALML4 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia calml4 33
  • 66.23 (n)
zebrafish
(Danio rerio)
Actinopterygii calml4a 33 34
  • 67.54 (n)
Dr.15736 33
fruit fly
(Drosophila melanogaster)
Insecta CG30378 34
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToOne
Species where no ortholog for CALML4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALML4 Gene

ENSEMBL:
Gene Tree for CALML4 (if available)
TreeFam:
Gene Tree for CALML4 (if available)

Paralogs for CALML4 Gene

Paralogs for CALML4 Gene

genes like me logo Genes that share paralogs with CALML4: view

Variants for CALML4 Gene

Sequence variations from dbSNP and Humsavar for CALML4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1022134304 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 68,207,608(-) A/T upstream_transcript_variant
rs1043527424 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 68,208,008(-) G/A upstream_transcript_variant
rs111879561 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 68,207,473(-) C/G/T upstream_transcript_variant
rs114551417 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 68,207,206(-) C/A upstream_transcript_variant
rs144976448 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 68,207,494(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CALML4 Gene

Variant ID Type Subtype PubMed ID
nsv1581 CNV insertion 18451855

Variation tolerance for CALML4 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALML4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALML4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML4 Gene

Disorders for CALML4 Gene

Additional Disease Information for CALML4

No disorders were found for CALML4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALML4 Gene

Publications for CALML4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan MJ … Old LJ (Cancer immunity 2001) 3 4 58
  3. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) GENDEP Investigators … STAR*D Investigators (The American journal of psychiatry 2013) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for CALML4 Gene

Sources for CALML4 Gene

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