Aliases for CALM3 Gene
External Ids for CALM3 Gene
Previous GeneCards Identifiers for CALM3 Gene
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
GeneCards Summary for CALM3 Gene
CALM3 (Calmodulin 3) is a Protein Coding gene. Diseases associated with CALM3 include Long Qt Syndrome 16 and Long Qt Syndrome 1. Among its related pathways are RET signaling and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM1.
UniProtKB/Swiss-Prot Summary for CALM3 Gene
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.