Aliases for CALM3 Gene
Aliases for CALM3 Gene
External Ids for CALM3 Gene
- HGNC: 1449
- Entrez Gene: 808
- Ensembl: ENSG00000160014
- OMIM: 114183
- UniProtKB: P0DP25
Previous GeneCards Identifiers for CALM3 Gene
- GC19P047748
- GC19P047495
- GC19P051780
- GC19P051797
- GC19P051798
- GC19P051799
- GC19P047105
- GC19P043529
Summaries for CALM3 Gene
-
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
GeneCards Summary for CALM3 Gene
CALM3 (Calmodulin 3) is a Protein Coding gene. Diseases associated with CALM3 include Long Qt Syndrome 1 and Catecholaminergic Polymorphic Ventricular Tachycardia. Among its related pathways are Post NMDA receptor activation events and Cytoskeleton remodeling_RalA regulation pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM2.
UniProtKB/Swiss-Prot for CALM3 Gene
-
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Additional gene information for CALM3 Gene
- Monarch Initiative
- Search for CALM3 at DataMed
- Search for CALM3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALM3 Gene
Genomics for CALM3 Gene
GeneHancer (GH) Regulatory Elements for CALM3 Gene
Promoters and enhancers for CALM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CALM3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CALM3 gene promoter:
-
- AREB6
- c-Myc
- C/EBPalpha
- CHOP-10
- GATA-1
- Max
- MyoD
- SRF
- SRF (504 AA)
- STAT5B
Genomic Locations for CALM3 Gene
Genomic Locations for CALM3 Gene
- chr19:46,601,074-46,610,793
- (GRCh38/hg38)
- Size:
- 9,720 bases
- Orientation:
- Plus strand
- chr19:47,104,331-47,114,050
- (GRCh37/hg19)
- Size:
- 9,720 bases
- Orientation:
- Plus strand
Genomic View for CALM3 Gene
Genes around CALM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by HGNC
- 19q13.32 by Entrez Gene
- 19q13.32 by Ensembl
CALM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALM3 Gene
Proteins for CALM3 Gene
-
Protein details for CALM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DP25-CALM3_HUMAN
- Recommended name:
- Calmodulin-3
- Protein Accession:
- P0DP25
- P02593
- P62158
- P70667
- P99014
- Q13942
- Q53S29
- Q61379
- Q61380
- Q96HK3
Protein attributes for CALM3 Gene
- Size:
- 149 amino acids
- Molecular mass:
- 16838 Da
- Quaternary structure:
-
- Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).
- Miscellaneous:
-
- This protein has four functional calcium-binding sites.
- SequenceCaution:
-
- Sequence=CAA36839.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CALM3 Gene
Post-translational modifications for CALM3 Gene
- Ubiquitination results in a strongly decreased activity.
- Phosphorylation results in a decreased activity.
Other Protein References for CALM3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CALM3
- Novus Biologicals Antibodies for CALM3
- Invitrogen Antibodies for CALM3 (AFLGC-CALM3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALM3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CALM3
- Origene Custom Protein Services for CALM3
Assay Products
No data available for DME Specific Peptides for CALM3 Gene
Domains & Families for CALM3 Gene
Gene Families for CALM3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for CALM3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CALM3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61744, highly similar to Calmodulin (B4DJ51_HUMAN)
- Calmodulin (CALM_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P0DP25- Family:
-
- Belongs to the calmodulin family.
Function for CALM3 Gene
Molecular function for CALM3 Gene
- UniProtKB/Swiss-Prot Function:
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
- GENATLAS Biochemistry:
- calmodulin 3,calcium modulated protein
Phenotypes From GWAS Catalog for CALM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IDA | 7607248 |
| GO:0005515 | protein binding | IPI | 3111527 |
| GO:0008179 | adenylate cyclase binding | IPI | 11807546 |
| GO:0010856 | adenylate cyclase activator activity | IDA | 11807546 |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for CALM3 Gene
- GenomeRNAi human phenotypes for CALM3:
-
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased viability
- Increased viability with tamoxifen
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALM3
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CALM3 - Now 50% OFF >
- * CALM3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CALM3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CALM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALM3
- genomics-online: gRNA clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALM3
miRNA for CALM3 Gene
- miRTarBase miRNAs that target CALM3
-
- hsa-mir-1-3p (MIRT004467)
- hsa-mir-7-5p (MIRT025949)
- hsa-mir-320a (MIRT044685)
- hsa-mir-27b-3p (MIRT046170)
- hsa-mir-490-5p (MIRT082502)
- hsa-mir-432-3p (MIRT082503)
- hsa-mir-641 (MIRT082504)
- hsa-mir-1972 (MIRT082505)
- hsa-mir-3142 (MIRT082506)
- hsa-mir-3617-5p (MIRT082507)
- hsa-mir-4650-5p (MIRT082508)
- hsa-mir-1245b-5p (MIRT082510)
- hsa-mir-4802-3p (MIRT082511)
- hsa-mir-6077 (MIRT082513)
- hsa-mir-29a-3p (MIRT082514)
- hsa-mir-29b-3p (MIRT082515)
- hsa-mir-29c-3p (MIRT082516)
- hsa-mir-4304 (MIRT082518)
- hsa-mir-3622b-5p (MIRT082519)
- hsa-mir-4678 (MIRT082520)
- hsa-mir-4733-3p (MIRT082521)
- hsa-mir-5187-5p (MIRT082523)
- hsa-mir-5682 (MIRT082524)
- hsa-mir-6728-5p (MIRT082527)
- hsa-mir-570-3p (MIRT082532)
- hsa-mir-4742-3p (MIRT082533)
- hsa-mir-196a-5p (MIRT235376)
- hsa-mir-196b-5p (MIRT235379)
- hsa-mir-185-5p (MIRT253002)
- hsa-mir-423-5p (MIRT253003)
- hsa-mir-510-5p (MIRT253005)
- hsa-mir-3184-5p (MIRT253007)
- hsa-mir-4306 (MIRT253008)
- hsa-mir-4253 (MIRT253009)
- hsa-mir-4644 (MIRT253011)
- hsa-mir-4688 (MIRT253012)
- hsa-mir-6734-5p (MIRT253013)
- hsa-mir-6743-5p (MIRT253014)
- hsa-mir-6862-5p (MIRT253015)
- hsa-mir-143-3p (MIRT348502)
- hsa-mir-4770 (MIRT348508)
- hsa-mir-6088 (MIRT348509)
- hsa-mir-6871-3p (MIRT376288)
- hsa-mir-3978 (MIRT480168)
- hsa-mir-6124 (MIRT480169)
- hsa-mir-3148 (MIRT480170)
- hsa-mir-1208 (MIRT480171)
- hsa-mir-6760-3p (MIRT480172)
- hsa-mir-6079 (MIRT480173)
- hsa-mir-1193 (MIRT480174)
- hsa-mir-585-5p (MIRT494387)
- hsa-mir-589-3p (MIRT494388)
- hsa-mir-4699-3p (MIRT494389)
- hsa-mir-4773 (MIRT494390)
- hsa-mir-4260 (MIRT513256)
- hsa-mir-5192 (MIRT513258)
- hsa-mir-6738-5p (MIRT513259)
- hsa-mir-5194 (MIRT513260)
- hsa-mir-1914-3p (MIRT513261)
- hsa-mir-1207-5p (MIRT736008)
- hsa-mir-122-5p (MIRT736106)
- hsa-mir-1237-5p (MIRT736300)
- hsa-mir-1253 (MIRT736534)
- hsa-mir-1266-5p (MIRT736700)
- hsa-mir-1276 (MIRT736952)
- hsa-mir-1827 (MIRT738085)
- hsa-mir-1909-3p (MIRT738340)
- hsa-mir-211-3p (MIRT738924)
- hsa-mir-3185 (MIRT740895)
- hsa-mir-335-5p (MIRT741345)
- hsa-mir-3616-3p (MIRT741661)
- hsa-mir-3659 (MIRT741950)
- hsa-mir-3665 (MIRT742039)
- hsa-mir-3925-5p (MIRT743000)
- hsa-mir-4270 (MIRT743550)
- hsa-mir-4428 (MIRT744301)
- hsa-mir-4441 (MIRT744517)
- hsa-mir-4488 (MIRT745222)
- hsa-mir-4514 (MIRT745696)
- hsa-mir-4518 (MIRT745773)
- hsa-mir-4649-5p (MIRT746496)
- hsa-mir-4692 (MIRT747104)
- hsa-mir-4693-3p (MIRT747139)
- hsa-mir-4697-5p (MIRT747226)
- hsa-mir-4709-3p (MIRT747376)
- hsa-mir-4711-5p (MIRT747441)
- hsa-mir-4736 (MIRT747988)
- hsa-mir-4763-3p (MIRT748517)
- hsa-mir-4783-5p (MIRT748812)
- hsa-mir-486-3p (MIRT749092)
- hsa-mir-5197-3p (MIRT750080)
- hsa-mir-541-3p (MIRT750359)
- hsa-mir-548aj-5p (MIRT750523)
- hsa-mir-548f-5p (MIRT750712)
- hsa-mir-548g-5p (MIRT750723)
- hsa-mir-548x-5p (MIRT750825)
- hsa-mir-564 (MIRT751107)
- hsa-mir-5700 (MIRT751331)
- hsa-mir-654-5p (MIRT753430)
- hsa-mir-6721-5p (MIRT753780)
- hsa-mir-6722-3p (MIRT753853)
- hsa-mir-6729-5p (MIRT753959)
- hsa-mir-6754-5p (MIRT754692)
- hsa-mir-6808-5p (MIRT756554)
- hsa-mir-6846-5p (MIRT757426)
- hsa-mir-6848-5p (MIRT757500)
- hsa-mir-6893-5p (MIRT758698)
- hsa-mir-7112-3p (MIRT759075)
- hsa-mir-940 (MIRT760795)
- hsa-mir-9500 (MIRT760872)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CALM3
- Browse OriGene Inhibitory RNA Products For CALM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALM3
- genomics-online: shRNA clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CALM3 - Now 50% OFF >
- * CALM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CALM3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG201052
- MR201052
- MR201052L1
- MR201052L1V
- MR201052L2
- MR201052L2V
- MR201052L3
- MR201052L3V
- MR201052L4
- MR201052L4V
- RC200331
- RC200331L1
- RC200331L1V
- RC200331L2
- RC200331L2V
- RC200331L3
- RC200331L3V
- RC200331L4
- RC200331L4V
- RG200331
- RR214855
- RR214855L1
- RR214855L1V
- RR214855L2
- RR214855L2V
- RR214855L3
- RR214855L3V
- RR214855L4
- RR214855L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CALM3
- Addgene plasmids for CALM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALM3
Cell Line Products
-
Horizon Cell Lines for CALM3
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CALM3 Gene
Localization for CALM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALM3 Gene
- Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| extracellular | 4 |
| nucleus | 4 |
| cytosol | 4 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IDA,IEA | 16760425 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005737 | cytoplasm | TAS | 10899953 |
| GO:0005813 | centrosome | IDA | 16760425 |
| GO:0005815 | microtubule organizing center | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALM3 Gene
Pathways & Interactions for CALM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | DAG and IP3 signaling |
.93
|
|
| 3 | Post NMDA receptor activation events | ||
| 4 | Development Angiotensin activation of ERK | ||
| 5 | Development Endothelin-1/EDNRA signaling | ||
Pathways by source for CALM3 Gene
3 Sino Biological pathways for CALM3 Gene
20 BioSystems pathways for CALM3 Gene
40 KEGG pathways for CALM3 Gene
35 GeneGo (Thomson Reuters) pathways for CALM3 Gene
41 Qiagen pathways for CALM3 Gene
Interacting Proteins for CALM3 Gene
GPS-Prot Interaction Network for CALM3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IEA | -- |
| GO:0001975 | response to amphetamine | IEA | -- |
| GO:0002027 | regulation of heart rate | IMP | 23040497 |
| GO:0005513 | detection of calcium ion | IMP | 23040497 |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | 10899953 |
No data available for SIGNOR curated interactions for CALM3 Gene
Transcripts for CALM3 Gene
mRNA/cDNA for CALM3 Gene
- (7) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (1153) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000291295 2289 bps (ENST00000291295.13)
- ENST00000391918 702 bps (ENST00000391918.6)
- ENST00000477244 696 bps (ENST00000477244.5)
- ENST00000482455 650 bps (ENST00000482455.5)
- ENST00000486500 2536 bps (ENST00000486500.1)
Unigene Clusters for CALM3 Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CALM3 - Now 50% OFF >
- * CALM3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CALM3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CALM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALM3
- genomics-online: gRNA clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALM3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CALM3
- Browse OriGene Inhibitory RNA Products For CALM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALM3
- genomics-online: shRNA clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CALM3 - Now 50% OFF >
- * CALM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CALM3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG201052
- MR201052
- MR201052L1
- MR201052L1V
- MR201052L2
- MR201052L2V
- MR201052L3
- MR201052L3V
- MR201052L4
- MR201052L4V
- RC200331
- RC200331L1
- RC200331L1V
- RC200331L2
- RC200331L2V
- RC200331L3
- RC200331L3V
- RC200331L4
- RC200331L4V
- RG200331
- RR214855
- RR214855L1
- RR214855L1V
- RR214855L2
- RR214855L2V
- RR214855L3
- RR214855L3V
- RR214855L4
- RR214855L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CALM3
- Addgene plasmids for CALM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALM3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: |
Expression for CALM3 Gene
mRNA differential expression in normal tissues according to GTEx for CALM3 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.1).
This gene is overexpressed in Lavage (13.7), Bone (10.1), and Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALM3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CALM3 Gene:
CALM3SOURCE GeneReport for Unigene cluster for CALM3 Gene:
Hs.515487Evidence on tissue expression from TISSUES for CALM3 Gene
- Nervous system(5)
- Kidney(4.6)
- Lung(4.4)
- Intestine(4.2)
- Liver(4)
- Blood(3.9)
- Eye(3.9)
- Muscle(3.9)
- Heart(3.7)
- Skin(3.5)
- Pancreas(3.2)
- Stomach(2.9)
- Adrenal gland(2.7)
- Spleen(2.7)
- Bone(2.6)
- Thyroid gland(2.6)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CALM3 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- ear
- head
Thorax:
- heart
- heart valve
Limb:
- lower limb
- upper limb
General:
- blood
- blood vessel
- red blood cell
Primer Products
-
OriGene qPCR primer pairs for CALM3
-
OriGene qPCR primer pairs and template standards for CALM3
- genomics-online: primer clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CALM3 Gene
Orthologs for CALM3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Calm3 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CALM3 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CALM3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| cow (Bos Taurus) |
Mammalia | CALM 35 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CALM1 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | calm1b 35 |
|
ManyToMany | |
| calm1a 35 |
|
ManyToMany | |||
| calm2a 35 |
|
ManyToMany | |||
| -- 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Cam 35 36 |
|
OneToMany | |
| And 36 |
|
|
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| CG11165 36 |
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| Mlc-c 36 |
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| TpnC41C 36 |
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| worm (Caenorhabditis elegans) |
Secernentea | cmd-1 35 36 |
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ManyToMany | |
| cal-6 35 |
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ManyToMany | |||
| Y73B3A.12 36 |
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| cal-1 36 |
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| cal-2 36 |
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| cal-4 36 |
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| cal-3 36 |
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| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CMD1 37 |
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| thale cress (Arabidopsis thaliana) |
eudicotyledons | CAM7 34 |
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| rice (Oryza sativa) |
Liliopsida | Os01g0267900 34 |
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| Os.10290 34 |
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| corn (Zea mays) |
Liliopsida | Zm.176 34 |
|
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| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10340 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04120 34 |
|
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| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cam1 34 |
|
- Species where no ortholog for CALM3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for CALM3 Gene
- ENSEMBL:
- Gene Tree for CALM3 (if available)
- TreeFam:
- Gene Tree for CALM3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CALM3: view image
Paralogs for CALM3 Gene
Paralogs for CALM3 Gene
(53) SIMAP similar genes for CALM3 Gene using alignment to 3 proteins:
- CALM_HUMAN
- B4DJ51_HUMAN
- M0QZ52_HUMAN
- CALM2
- CALM1
- CALML3
- CALML5
- TNNC2
- CETN1
- CETN2
- TNNC1
- CABP5
- CALML6
- CALN1
- CABP1
- MYL9
- MYL12B
- MYL1
- MYL4
- MYL3
- CALML4
- CABP2
- MYL6
- OCM
- MYL5
- MYL2
- CABP4
- OCM2
- CETN3
- EFCAB2
- MYL12A
- PLS1
- MYL10
- PPP3R1
- MYL6B
- HZGJ
- PPP3R2
- EFCAB3
- AIF1
- ACTN2
- MYLPF
- ACTN4
- SLC25A24
- EFCAB7
- CIB2
- ACTN3
- ACTN1
- MYL7
- SPTAN1
- DUOX1
- PVALB
- GPD2
- AIF1L
- GUCA1B
- DKFZp686E1183
- HPCAL1
Pseudogenes.org Pseudogenes for CALM3 Gene
Variants for CALM3 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001080500 | likely-benign, Long QT syndrome 1 | 46,605,847(+) | G/A | 5_prime_UTR_variant, coding_sequence_variant, intron_variant, synonymous_variant | |
| rs1060502607 | uncertain-significance, Long QT syndrome 1 | 46,608,846(+) | G/C | coding_sequence_variant, missense_variant | |
| rs1060502608 | pathogenic, Long QT syndrome 1 | 46,608,584(+) | A/C | coding_sequence_variant, missense_variant | |
| rs115265989 | benign, likely-benign, Long QT syndrome 1, not specified | 46,608,570(+) | G/A | coding_sequence_variant, synonymous_variant | |
| rs146819515 | benign, likely-benign, Long QT syndrome 1, not specified | 46,608,866(+) | C/T | coding_sequence_variant, synonymous_variant |
Residual Variation Intolerance Score:
45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CALM3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALM3 Gene
Disorders for CALM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| long qt syndrome 1 |
|
|
| catecholaminergic polymorphic ventricular tachycardia |
|
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| long qt syndrome |
|
|
| phencyclidine abuse |
|
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| cardiac arrest |
|
|
Search CALM3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CALM3_HUMAN- Note=Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare condition caused by mutation in CALM3 that lead to an arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269 PubMed:27516456}.
Additional Disease Information for CALM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CALM3 Gene
Publications for CALM3 Gene
- Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. (PMID: 27516456) Gomez-Hurtado N … Knollmann BC (Circulation. Arrhythmia and electrophysiology 2016) 3 4 58
- Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. (PMID: 22484487) Umasankar PK … Traub LM (Nature cell biology 2012) 3 4 58
- Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. (PMID: 23109337) Liu Y … Birnbaumer L (The Journal of biological chemistry 2012) 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
- Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. (PMID: 20466722) Wang Z … Qi RZ (The Journal of biological chemistry 2010) 3 4 58
ExternalLinks
Products for CALM3 Gene
- Custom Antibody ServicesOriGene Antibodies for CALM3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CALM3
- Origene Custom Protein Services for CALM3
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CALM3
- Browse OriGene Inhibitory RNA Products For CALM3
- OriGene qPCR primer pairs for CALM3
- OriGene qPCR primer pairs and template standards for CALM3
- OriGene CRISPR knockouts for CALM3
- MG201052
- MR201052
- MR201052L1
- MR201052L1V
- MR201052L2
- MR201052L2V
- MR201052L3
- MR201052L3V
- MR201052L4
- MR201052L4V
- RC200331
- RC200331L1
- RC200331L1V
- RC200331L2
- RC200331L2V
- RC200331L3
- RC200331L3V
- RC200331L4
- RC200331L4V
- RG200331
- RR214855
- RR214855L1
- RR214855L1V
- RR214855L2
- RR214855L2V
- RR214855L3
- RR214855L3V
- RR214855L4
- RR214855L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CALM3
- Sino Biological Human cDNA Clone for CALM3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CALM3
- Novus Biologicals proteins and lysates for CALM3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for CALM3 (AFLGC-CALM3)
- antibodies-online: Search results for 15 available CALM1 Antibodies ranked by validation data
- Compare Top CALM1 Antibodies
- antibodies-online: Search results for 3 available CALM1 Elisa Kits ranked by validation data
- Compare Top CALM1 Elisa Kits
- antibodies-online: Search results for 2 available CALM1 Proteins ranked by validation data
- Compare Top CALM1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CALM3
- Search Santa Cruz Biotechnology (SCBT) for CALM3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CALM3
- Horizon Cell Lines for CALM3
- genomics-online: cdna clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
- orf clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
- genomics-online: gRNA clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
- genomics-online: primer clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
- genomics-online: shRNA clones - Search results for 125 available CALM1 gene related products
- Overview of 125 available CALM1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALM3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CALM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALM3
Sources for CALM3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas