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This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
CALM3 (Calmodulin 3) is a Protein Coding gene. Diseases associated with CALM3 include Long Qt Syndrome 16 and Long Qt Syndrome 1. Among its related pathways are DAG and IP3 signaling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IBA,IDA | 7607248 |
GO:0005515 | protein binding | IPI | 3111527 |
GO:0008179 | adenylate cyclase binding | IPI | 11807546 |
GO:0010856 | adenylate cyclase activator activity | IDA | 11807546 |
GO:0016301 | kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000922 | spindle pole | IEA,IDA | 16760425 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | TAS | 10899953 |
GO:0005813 | centrosome | IDA | 16760425 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | DAG and IP3 signaling |
.93
|
Signal transduction Calcium signaling
.35
Development Beta-adrenergic receptors signaling via cAMP
.32
|
3 | Post NMDA receptor activation events | ||
4 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
|
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
5 | Development Endothelin-1/EDNRA signaling |
Development Endothelin-1/EDNRA signaling
.41
Development Endothelin-1/EDNRA transactivation of EGFR
.41
Cytoskeleton remodeling FAK signaling
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | IEA | -- |
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0001975 | response to amphetamine | IEA | -- |
GO:0002027 | regulation of heart rate | IMP | 23040497 |
GO:0005513 | detection of calcium ion | IMP | 23040497 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CALM3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Calm3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CALM3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CALM 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CALM1 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | calm1b 31 |
|
ManyToMany | |
calm1a 31 |
|
ManyToMany | |||
calm2a 31 |
|
ManyToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cam 31 32 |
|
OneToMany | |
And 32 |
|
|
|||
CG11165 32 |
|
|
|||
Mlc-c 32 |
|
|
|||
TpnC41C 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | cmd-1 31 32 |
|
ManyToMany | |
cal-6 31 |
|
ManyToMany | |||
Y73B3A.12 32 |
|
|
|||
cal-1 32 |
|
|
|||
cal-2 32 |
|
|
|||
cal-4 32 |
|
|
|||
cal-3 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CMD1 33 |
|
|
|
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CAM7 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0267900 30 |
|
||
Os.10290 30 |
|
||||
Corn (Zea mays) |
Liliopsida | Zm.176 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10340 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04120 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cam1 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
654209 | Uncertain Significance: Romano-Ward syndrome | 46,608,293(+) | C/T | MISSENSE_VARIANT | |
655350 | Uncertain Significance: Romano-Ward syndrome | 46,608,879(+) | C/T | MISSENSE_VARIANT | |
659570 | Uncertain Significance: Romano-Ward syndrome | 46,608,209(+) | C/G | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
678453 | Benign: not provided | 46,605,754(+) | T/C | INTRON_VARIANT | |
678454 | Benign: not provided | 46,608,406(+) | T/C | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
long qt syndrome 16 |
|
|
long qt syndrome 1 |
|
|
catecholaminergic polymorphic ventricular tachycardia |
|
|
long qt syndrome |
|
|
long qt syndrome 14 |
|
|