Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016] See more...
Aliases for CALM3 Gene
Aliases for CALM3 Gene
External Ids for CALM3 Gene
- HGNC: 1449
- NCBI Entrez Gene: 808
- Ensembl: ENSG00000160014
- OMIM®: 114183
- UniProtKB/Swiss-Prot: P0DP25
Previous GeneCards Identifiers for CALM3 Gene
- GC19P047748
- GC19P047495
- GC19P051780
- GC19P051797
- GC19P051798
- GC19P051799
- GC19P047105
- GC19P043529
Summaries for CALM3 Gene
-
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
GeneCards Summary for CALM3 Gene
CALM3 (Calmodulin 3) is a Protein Coding gene. Diseases associated with CALM3 include Long Qt Syndrome 16 and Long Qt Syndrome 1. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM1.
UniProtKB/Swiss-Prot Summary for CALM3 Gene
-
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Additional gene information for CALM3 Gene
- HGNC (1449)
- NCBI Entrez Gene (808)
- Ensembl (ENSG00000160014)
- OMIM® (114183)
- UniProtKB/Swiss-Prot (P0DP25)
- Open Targets Platform(ENSG00000160014)
- Monarch Initiative
- Search for CALM3 at DataMed
- Search for CALM3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALM3 Gene
Genomics for CALM3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CALM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CALM3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALM3
- Top Transcription factor binding sites by QIAGEN in the CALM3 gene promoter:
-
- AREB6
- c-Myc
- C/EBPalpha
- CHOP-10
- GATA-1
- Max
- MyoD
- SRF
- SRF (504 AA)
- STAT5B
Genomic Locations for CALM3 Gene
Latest Assembly
- chr19:46,601,074-46,610,782
- (GRCh38/hg38)
- Size:
- 9,709 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:47,104,331-47,114,039
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,709 bases
- Orientation:
- Plus strand
- chr19:47,104,331-47,114,050
- (GRCh37/hg19 by Ensembl)
- Size:
- 9,720 bases
- Orientation:
- Plus strand
Genomic View for CALM3 Gene
Genes around CALM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by HGNC
- 19q13.32 by Entrez Gene
- 19q13.32 by Ensembl
CALM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALM3 Gene
Proteins for CALM3 Gene
-
Protein details for CALM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DP25-CALM3_HUMAN
- Recommended name:
- Calmodulin-3
- Protein Accession:
- P0DP25
- P02593
- P62158
- P70667
- P99014
- Q13942
- Q53S29
- Q61379
- Q61380
- Q96HK3
Protein attributes for CALM3 Gene
- Size:
- 149 amino acids
- Molecular mass:
- 16838 Da
- Quaternary structure:
-
- Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).
- SequenceCaution:
-
- Sequence=CAA36839.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
- Miscellaneous:
-
- This protein has four functional calcium-binding sites.
Protein Expression for CALM3 Gene
Post-translational modifications for CALM3 Gene
- Ubiquitination results in a strongly decreased activity.
- Phosphorylation results in a decreased activity.
Other Protein References for CALM3 Gene
Antibodies for research
- Novus Biologicals Antibodies for CALM3
- Invitrogen Antibodies for CALM3 (AFLGC-CALM3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALM3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CALM3
- Origene Custom Protein Services for CALM3
No data available for DME Specific Peptides for CALM3 Gene
Domains & Families for CALM3 Gene
Gene Families for CALM3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for CALM3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CALM3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61744, highly similar to Calmodulin (B4DJ51_HUMAN)
- Calmodulin (CALM_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P0DP25- Family:
-
- Belongs to the calmodulin family.
Function for CALM3 Gene
Molecular function for CALM3 Gene
- UniProtKB/Swiss-Prot Function:
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
- GENATLAS Biochemistry:
- calmodulin 3,calcium modulated protein
Phenotypes From GWAS Catalog for CALM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IBA,IDA | 7607248 |
| GO:0005515 | protein binding | IPI | 3111527 |
| GO:0008179 | adenylate cyclase binding | IPI | 11807546 |
| GO:0010856 | adenylate cyclase activator activity | IDA | 11807546 |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for CALM3 Gene
- GenomeRNAi human phenotypes for CALM3:
-
- Increased gamma-H2AX phosphorylation
- Increased vaccinia virus (VACV) infection
- Increased viability
- no effect
- Reduced mammosphere formation
- Resistant to vaccinia virus (VACV-A4L) infection
- Strongly decreased CFP-tsO45G cell surface transport
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased caspase activity
- Decreased viability
- Increased viability with tamoxifen
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CALM3 - Starting at $85 >
- * CALM3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CALM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALM3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALM3
miRNA for CALM3 Gene
- miRTarBase miRNAs that target CALM3
-
- hsa-miR-1-3p (MIRT004467)
- rno-miR-1-3p (MIRT007409)
- hsa-miR-7-5p (MIRT025949)
- hsa-miR-320a (MIRT044685)
- hsa-miR-27b-3p (MIRT046170)
- hsa-miR-490-5p (MIRT082502)
- hsa-miR-432-3p (MIRT082503)
- hsa-miR-641 (MIRT082504)
- hsa-miR-1972 (MIRT082505)
- hsa-miR-3142 (MIRT082506)
- hsa-miR-3617-5p (MIRT082507)
- hsa-miR-4650-5p (MIRT082508)
- hsa-miR-1245b-5p (MIRT082510)
- hsa-miR-4802-3p (MIRT082511)
- hsa-miR-6077 (MIRT082513)
- hsa-miR-29a-3p (MIRT082514)
- hsa-miR-29b-3p (MIRT082515)
- hsa-miR-29c-3p (MIRT082516)
- hsa-miR-4304 (MIRT082518)
- hsa-miR-3622b-5p (MIRT082519)
- hsa-miR-4678 (MIRT082520)
- hsa-miR-4733-3p (MIRT082521)
- hsa-miR-5187-5p (MIRT082523)
- hsa-miR-5682 (MIRT082524)
- hsa-miR-6728-5p (MIRT082527)
- hsa-miR-570-3p (MIRT082532)
- hsa-miR-4742-3p (MIRT082533)
- hsa-miR-196a-5p (MIRT235376)
- hsa-miR-196b-5p (MIRT235379)
- hsa-miR-185-5p (MIRT253002)
- hsa-miR-423-5p (MIRT253003)
- hsa-miR-510-5p (MIRT253005)
- hsa-miR-3184-5p (MIRT253007)
- hsa-miR-4306 (MIRT253008)
- hsa-miR-4253 (MIRT253009)
- hsa-miR-4644 (MIRT253011)
- hsa-miR-4688 (MIRT253012)
- hsa-miR-6734-5p (MIRT253013)
- hsa-miR-6743-5p (MIRT253014)
- hsa-miR-6862-5p (MIRT253015)
- hsa-miR-143-3p (MIRT348502)
- hsa-miR-4770 (MIRT348508)
- hsa-miR-6088 (MIRT348509)
- hsa-miR-6871-3p (MIRT376288)
- hsa-miR-3978 (MIRT480168)
- hsa-miR-6124 (MIRT480169)
- hsa-miR-3148 (MIRT480170)
- hsa-miR-1208 (MIRT480171)
- hsa-miR-6760-3p (MIRT480172)
- hsa-miR-6079 (MIRT480173)
- hsa-miR-1193 (MIRT480174)
- hsa-miR-585-5p (MIRT494387)
- hsa-miR-589-3p (MIRT494388)
- hsa-miR-4699-3p (MIRT494389)
- hsa-miR-4773 (MIRT494390)
- hsa-miR-4260 (MIRT513256)
- hsa-miR-5192 (MIRT513258)
- hsa-miR-6738-5p (MIRT513259)
- hsa-miR-5194 (MIRT513260)
- hsa-miR-1914-3p (MIRT513261)
- hsa-miR-1207-5p (MIRT736008)
- hsa-miR-122-5p (MIRT736106)
- hsa-miR-1237-5p (MIRT736300)
- hsa-miR-1253 (MIRT736534)
- hsa-miR-1266-5p (MIRT736700)
- hsa-miR-1276 (MIRT736952)
- hsa-miR-1827 (MIRT738085)
- hsa-miR-1909-3p (MIRT738340)
- hsa-miR-211-3p (MIRT738924)
- hsa-miR-3185 (MIRT740895)
- hsa-miR-335-5p (MIRT741345)
- hsa-miR-3616-3p (MIRT741661)
- hsa-miR-3659 (MIRT741950)
- hsa-miR-3665 (MIRT742039)
- hsa-miR-3925-5p (MIRT743000)
- hsa-miR-4270 (MIRT743550)
- hsa-miR-4428 (MIRT744301)
- hsa-miR-4441 (MIRT744517)
- hsa-miR-4488 (MIRT745222)
- hsa-miR-4514 (MIRT745696)
- hsa-miR-4518 (MIRT745773)
- hsa-miR-4649-5p (MIRT746496)
- hsa-miR-4692 (MIRT747104)
- hsa-miR-4693-3p (MIRT747139)
- hsa-miR-4697-5p (MIRT747226)
- hsa-miR-4709-3p (MIRT747376)
- hsa-miR-4711-5p (MIRT747441)
- hsa-miR-4736 (MIRT747988)
- hsa-miR-4763-3p (MIRT748517)
- hsa-miR-4783-5p (MIRT748812)
- hsa-miR-486-3p (MIRT749092)
- hsa-miR-5197-3p (MIRT750080)
- hsa-miR-541-3p (MIRT750359)
- hsa-miR-548aj-5p (MIRT750523)
- hsa-miR-548f-5p (MIRT750712)
- hsa-miR-548g-5p (MIRT750723)
- hsa-miR-548x-5p (MIRT750825)
- hsa-miR-564 (MIRT751107)
- hsa-miR-5700 (MIRT751331)
- hsa-miR-654-5p (MIRT753430)
- hsa-miR-6721-5p (MIRT753780)
- hsa-miR-6722-3p (MIRT753853)
- hsa-miR-6729-5p (MIRT753959)
- hsa-miR-6754-5p (MIRT754692)
- hsa-miR-6808-5p (MIRT756554)
- hsa-miR-6846-5p (MIRT757426)
- hsa-miR-6848-5p (MIRT757500)
- hsa-miR-6893-5p (MIRT758698)
- hsa-miR-7112-3p (MIRT759075)
- hsa-miR-940 (MIRT760795)
- hsa-miR-9500 (MIRT760872)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALM3
- Browse OriGene Inhibitory RNA Products For CALM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALM3
Clone products for research
- Applied Biological Materials (abm): Clones for CALM3 - Starting at $45 >
- * CALM3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CALM3
- Addgene plasmids for CALM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALM3
Cell Lines for research
-
Horizon Cell Lines for CALM3
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CALM3 Gene
Localization for CALM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALM3 Gene
- Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| extracellular | 4 |
| nucleus | 4 |
| cytosol | 4 |
| mitochondrion | 3 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA,IDA | 16760425 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005737 | cytoplasm | TAS | 10899953 |
| GO:0005813 | centrosome | IDA | 16760425 |
| GO:0005815 | microtubule organizing center | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALM3 Gene
Pathways & Interactions for CALM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | DAG and IP3 signaling |
.93
|
Signal transduction Calcium signaling
.35
Development Beta-adrenergic receptors signaling via cAMP
.32
|
| 3 | Post NMDA receptor activation events | ||
| 4 | Development Angiotensin activation of ERK |
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
|
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
|
| 5 | Development Endothelin-1/EDNRA signaling |
Development Endothelin-1/EDNRA signaling
.41
Development Endothelin-1/EDNRA transactivation of EGFR
.41
Cytoskeleton remodeling FAK signaling
.41
|
|
Pathways by source for CALM3 Gene
3 Sino Biological pathways for CALM3 Gene
20 BioSystems pathways for CALM3 Gene
42 KEGG pathways for CALM3 Gene
35 GeneGo (Thomson Reuters) pathways for CALM3 Gene
- Cell adhesion Integrin inside-out signaling
- Cytoskeleton remodeling FAK signaling
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Cytoskeleton remodeling_RalA regulation pathway
- Cytoskeleton remodeling_RalB regulation pathway
41 Qiagen pathways for CALM3 Gene
- Activation of cAMP-Dependent PKA
- Alpha-Adrenergic Signaling
- Androgen Signaling
- Breast Cancer Regulation by Stathmin1
- Calcium Mediated T-Cell Apoptosis
Interacting Proteins for CALM3 Gene
Selected Interacting proteins:
P0DP25-CALM3_HUMAN
ENSP00000291295
for CALM3 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for CALM3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IEA | -- |
| GO:0000226 | microtubule cytoskeleton organization | IBA | -- |
| GO:0001975 | response to amphetamine | IEA | -- |
| GO:0002027 | regulation of heart rate | IMP | 23040497 |
| GO:0005513 | detection of calcium ion | IMP | 23040497 |
No data available for SIGNOR curated interactions for CALM3 Gene
Transcripts for CALM3 Gene
mRNA/cDNA for CALM3 Gene
- 7 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000291295 2184 nts (view in UCSC)
- ENST00000391918 702 nts (view in UCSC)
- ENST00000477244 696 nts (view in UCSC)
- ENST00000482455 650 nts (view in UCSC)
- ENST00000486500 2536 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CALM3 - Starting at $85 >
- * CALM3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CALM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALM3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALM3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALM3
- Browse OriGene Inhibitory RNA Products For CALM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALM3
Clone products for research
- Applied Biological Materials (abm): Clones for CALM3 - Starting at $45 >
- * CALM3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CALM3
- Addgene plasmids for CALM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CALM3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for CALM3 Gene
- GeneLoc Exon Structure for
- CALM3
Expression for CALM3 Gene
mRNA differential expression in normal tissues according to GTEx for CALM3 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.1).
This gene is overexpressed in Lavage (13.7), Bone (10.1), and Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALM3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALM3
SOURCE GeneReport for Unigene cluster for CALM3 Gene:
Hs.515487Evidence on tissue expression from TISSUES for CALM3 Gene
- Nervous system(5)
- Lung(4.8)
- Liver(4.8)
- Blood(4.7)
- Kidney(4.4)
- Intestine(4.1)
- Eye(3.5)
- Skin(3.5)
- Heart(3.2)
- Muscle(3.1)
- Pancreas(2.6)
- Spleen(2.6)
- Stomach(2.4)
- Bone(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CALM3 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- ear
- head
Thorax:
- heart
- heart valve
Limb:
- lower limb
- upper limb
General:
- blood
- blood vessel
- red blood cell
Primer products for research
-
OriGene qPCR primer pairs for CALM3
-
OriGene qPCR primer pairs and template standards for CALM3
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CALM3 Gene
Orthologs for CALM3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CALM3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Mouse (Mus musculus) |
Mammalia | Calm3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CALM3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CALM 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CALM1 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | calm1b 31 |
|
ManyToMany | |
| calm1a 31 |
|
ManyToMany | |||
| calm2a 31 |
|
ManyToMany | |||
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cam 31 32 |
|
OneToMany | |
| And 32 |
|
|
|||
| CG11165 32 |
|
|
|||
| Mlc-c 32 |
|
|
|||
| TpnC41C 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | cmd-1 31 32 |
|
ManyToMany | |
| cal-6 31 |
|
ManyToMany | |||
| Y73B3A.12 32 |
|
|
|||
| cal-1 32 |
|
|
|||
| cal-2 32 |
|
|
|||
| cal-4 32 |
|
|
|||
| cal-3 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CMD1 33 |
|
|
|
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CAM7 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0267900 30 |
|
||
| Os.10290 30 |
|
||||
| Corn (Zea mays) |
Liliopsida | Zm.176 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10340 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04120 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cam1 30 |
|
- Species where no ortholog for CALM3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for CALM3 Gene
- ENSEMBL:
- Gene Tree for CALM3 (if available)
- TreeFam:
- Gene Tree for CALM3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CALM3: view image