Aliases for CALM1 Gene
Aliases for CALM1 Gene
External Ids for CALM1 Gene
- HGNC: 1442
- Entrez Gene: 801
- Ensembl: ENSG00000198668
- OMIM: 114180
- UniProtKB: P0DP23
Previous HGNC Symbols for CALM1 Gene
- CALML2
Previous GeneCards Identifiers for CALM1 Gene
- GC14P088369
- GC14P084679
- GC14P088853
- GC14P089933
- GC14P090863
- GC14P071038
Summaries for CALM1 Gene
-
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
GeneCards Summary for CALM1 Gene
CALM1 (Calmodulin 1) is a Protein Coding gene. Diseases associated with CALM1 include Long Qt Syndrome 14 and Ventricular Tachycardia, Catecholaminergic Polymorphic, 4. Among its related pathways are RET signaling and N-cadherin signaling events. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM3.
UniProtKB/Swiss-Prot for CALM1 Gene
-
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).
Additional gene information for CALM1 Gene
- Monarch Initiative
- Search for CALM1 at DataMed
- Search for CALM1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALM1 Gene
Genomics for CALM1 Gene
GeneHancer (GH) Regulatory Elements for CALM1 Gene
Promoters and enhancers for CALM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CALM1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CALM1 gene promoter:
Regulatory Element Products
Genomic Locations for CALM1 Gene
Genomic Locations for CALM1 Gene
- chr14:90,396,502-90,408,275
- (GRCh38/hg38)
- Size:
- 11,774 bases
- Orientation:
- Plus strand
- chr14:90,862,846-90,874,619
- (GRCh37/hg19)
Genomic View for CALM1 Gene
Genes around CALM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.11 by Ensembl
- 14q32.11 by Entrez Gene
- 14q32.11 by HGNC
CALM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALM1 Gene
Proteins for CALM1 Gene
-
Protein details for CALM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DP23-CALM1_HUMAN
- Recommended name:
- Calmodulin-1
- Protein Accession:
- P0DP23
- P02593
- P62158
- P70667
- P99014
- Q13942
- Q53S29
- Q61379
- Q61380
- Q96HK3
Protein attributes for CALM1 Gene
- Size:
- 149 amino acids
- Molecular mass:
- 16838 Da
- Quaternary structure:
-
- Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (PubMed:21167176). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (PubMed:23893133). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434, PubMed:26164367). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).
- Miscellaneous:
-
- This protein has four functional calcium-binding sites.
Protein Expression for CALM1 Gene
Post-translational modifications for CALM1 Gene
- Phosphorylation results in a decreased activity.
- Ubiquitination results in a strongly decreased activity.
Other Protein References for CALM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for CALM1 (Calmodulin)
-
Custom Antibody ServicesOriGene Antibodies for CALM1
- Novus Biologicals Antibodies for CALM1
- Invitrogen Antibodies for CALM1
- Search GeneTex for Antibodies for CALM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALM1
Protein Products
-
OriGene Purified Proteins for CALM1
- Search Origene for MassSpec and Protein Over-expression Lysates for CALM1
- Origene Custom Protein Services for CALM1
- Search GeneTex for Proteins for CALM1
No data available for DME Specific Peptides for CALM1 Gene
Domains & Families for CALM1 Gene
Gene Families for CALM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for CALM1 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P0DP23- Family:
-
- Belongs to the calmodulin family.
No data available for Suggested Antigen Peptide Sequences for CALM1 Gene
Function for CALM1 Gene
Molecular function for CALM1 Gene
- GENATLAS Biochemistry:
- calmodulin 1,calcium modulated protein
- UniProtKB/Swiss-Prot Function:
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).
Phenotypes From GWAS Catalog for CALM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005509 | calcium ion binding | IDA,IEA | 7607248 |
| GO:0005515 | protein binding | IPI | 3111527 |
| GO:0008179 | adenylate cyclase binding | IPI | 11807546 |
| GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity | TAS | -- |
Phenotypes for CALM1 Gene
- GenomeRNAi human phenotypes for CALM1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability
- Synthetic lethal with imatinib mesylate
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased G1 length, increased G2 length
- Synthetic lethal with gemcitabine
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALM1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CALM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CALM1 gene
- Search ViGene Biosciences for CALM1
CRISPR Products
-
OriGene CRISPR knockouts for CALM1
- Applied Biological Materials CRISPR for CALM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALM1
- GenScript: Design CRISPR guide RNA sequences for CALM1
miRNA for CALM1 Gene
- miRTarBase miRNAs that target CALM1
-
- hsa-mir-1-3p (MIRT024054)
- hsa-let-7f-5p (MIRT053626)
- hsa-mir-129-5p (MIRT071460)
- hsa-mir-450b-5p (MIRT071461)
- hsa-mir-19a-3p (MIRT071480)
- hsa-mir-19b-3p (MIRT071481)
- hsa-mir-579-3p (MIRT071490)
- hsa-mir-595 (MIRT071491)
- hsa-mir-548c-3p (MIRT071492)
- hsa-mir-648 (MIRT071493)
- hsa-mir-664a-3p (MIRT071494)
- hsa-mir-4760-3p (MIRT071497)
- hsa-mir-664b-3p (MIRT071499)
- hsa-mir-548aw (MIRT071500)
- hsa-let-7c-3p (MIRT071501)
- hsa-mir-340-5p (MIRT071502)
- hsa-mir-3123 (MIRT071503)
- hsa-mir-4311 (MIRT071504)
- hsa-mir-4729 (MIRT071507)
- hsa-mir-539-5p (MIRT071515)
- hsa-mir-586 (MIRT114796)
- hsa-mir-196a-5p (MIRT191923)
- hsa-mir-196b-5p (MIRT191924)
- hsa-mir-495-5p (MIRT191943)
- hsa-mir-1305 (MIRT191944)
- hsa-mir-1250-3p (MIRT191945)
- hsa-mir-511-3p (MIRT280390)
- hsa-mir-548a-3p (MIRT405875)
- hsa-mir-548e-3p (MIRT405876)
- hsa-mir-548f-3p (MIRT405877)
- hsa-mir-548ar-3p (MIRT405879)
- hsa-mir-548az-3p (MIRT405880)
- hsa-mir-493-3p (MIRT441025)
- hsa-mir-142-3p (MIRT441026)
- hsa-mir-6867-5p (MIRT507912)
- hsa-mir-382-5p (MIRT507913)
- hsa-mir-3680-3p (MIRT512183)
- hsa-mir-557 (MIRT512184)
- hsa-mir-507 (MIRT512185)
- hsa-mir-4696 (MIRT512186)
- hsa-mir-3163 (MIRT524572)
- hsa-mir-583 (MIRT524573)
- hsa-mir-1276 (MIRT524574)
- hsa-mir-142-5p (MIRT524575)
- hsa-mir-5590-3p (MIRT524576)
- hsa-mir-4659b-3p (MIRT524577)
- hsa-mir-4659a-3p (MIRT524578)
- hsa-mir-4639-5p (MIRT538736)
- hsa-mir-502-5p (MIRT538737)
- hsa-mir-5589-3p (MIRT538738)
- hsa-mir-1915-5p (MIRT538739)
- hsa-mir-6841-3p (MIRT538740)
- hsa-mir-4662a-3p (MIRT538741)
- hsa-mir-3591-3p (MIRT538742)
- hsa-mir-21-3p (MIRT538743)
- hsa-mir-5696 (MIRT549060)
- hsa-mir-1468-3p (MIRT549061)
- hsa-mir-548x-5p (MIRT549062)
- hsa-mir-548g-5p (MIRT549063)
- hsa-mir-548f-5p (MIRT549064)
- hsa-mir-548aj-5p (MIRT549065)
- hsa-mir-1324 (MIRT558970)
- hsa-mir-382-3p (MIRT558971)
- hsa-mir-4538 (MIRT558972)
- hsa-mir-4453 (MIRT558973)
- hsa-mir-6882-5p (MIRT558974)
- hsa-mir-570-5p (MIRT558975)
- hsa-mir-548ba (MIRT558976)
- hsa-mir-548ai (MIRT558977)
- hsa-mir-548ag (MIRT558978)
- hsa-mir-5582-3p (MIRT558979)
- hsa-mir-3148 (MIRT765008)
- hsa-mir-4668-5p (MIRT770848)
- hsa-mir-4777-5p (MIRT772233)
- hsa-mir-518d-5p (MIRT773592)
- hsa-mir-518e-5p (MIRT773595)
- hsa-mir-518f-5p (MIRT773598)
- hsa-mir-519a-5p (MIRT773686)
- hsa-mir-519b-5p (MIRT773700)
- hsa-mir-519c-5p (MIRT773714)
- hsa-mir-520c-5p (MIRT773795)
- hsa-mir-520g-5p (MIRT773858)
- hsa-mir-522-5p (MIRT773893)
- hsa-mir-523-5p (MIRT773896)
- hsa-mir-526a (MIRT773909)
- hsa-mir-625-5p (MIRT776111)
- hsa-mir-6795-5p (MIRT779347)
- hsa-mir-6873-5p (MIRT780714)
- hsa-mir-6887-5p (MIRT781070)
miRNA Products
- Search ViGene Biosciences for CALM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CALM1
- Browse OriGene Inhibitory RNA Products For CALM1
-
ViGene Biosciences ready-to-package AAV shRNAs for CALM1 gene
Clone Products
- Sino Biological Human cDNA Clone for CALM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CALM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CALM1
- Applied Biological Materials Clones for CALM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CALM1
-
ViGene Biosciences adenoviral particle packaged cDNA for CALM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CALM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CALM1 gene
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CALM1 Gene
Localization for CALM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALM1 Gene
- Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| endosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA,IDA | 16760425 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | TAS,IEA | 10899953 |
Pathways & Interactions for CALM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | DAG and IP3 signaling |
.93
|
|
| 3 | Post NMDA receptor activation events | ||
| 4 | Development Angiotensin activation of ERK | ||
| 5 | Development Endothelin-1/EDNRA signaling | ||
Pathways by source for CALM1 Gene
3 Sino Biological pathways for CALM1 Gene
2 Cell Signaling Technology pathways for CALM1 Gene
31 BioSystems pathways for CALM1 Gene
37 KEGG pathways for CALM1 Gene
35 GeneGo (Thomson Reuters) pathways for CALM1 Gene
4 R&D Systems pathways for CALM1 Gene
41 Qiagen pathways for CALM1 Gene
Interacting Proteins for CALM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0002027 | regulation of heart rate | IMP | 23040497 |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0005513 | detection of calcium ion | IMP | 23040497 |
| GO:0005980 | glycogen catabolic process | TAS | -- |
No data available for SIGNOR curated interactions for CALM1 Gene
Drugs & Compounds for CALM1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Aprindine | Approved | Pharma | Target, inhibitor | 0 | ||
| Bepridil | Approved, Withdrawn | Pharma | Pore Blocker, Target, binder, blocker | 0 | ||
| Flunarizine | Approved | Pharma | Target, blocker | 5 | ||
| Dibucaine | Approved, Vet_approved | Pharma | Target, inhibitor | 0 | ||
| Felodipine | Approved, Investigational | Pharma | Potentiation, Activator, Target, other | 22 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 2-Methylpropan-2-ol |
|
75-65-0 |
Transcripts for CALM1 Gene
mRNA/cDNA for CALM1 Gene
- (3) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (1535) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CALM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CALM1
- Applied Biological Materials CRISPR for CALM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALM1
- GenScript: Design CRISPR guide RNA sequences for CALM1
miRNA Products
- Search ViGene Biosciences for CALM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CALM1
- Browse OriGene Inhibitory RNA Products For CALM1
-
ViGene Biosciences ready-to-package AAV shRNAs for CALM1 gene
Clone Products
- Sino Biological Human cDNA Clone for CALM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CALM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CALM1
- Applied Biological Materials Clones for CALM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: | - | - | - | - |
Expression for CALM1 Gene
This gene is overexpressed in Lavage (13.7), Bone (10.1), and Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CALM1 Gene:
CALM1SOURCE GeneReport for Unigene cluster for CALM1 Gene:
Hs.282410Evidence on tissue expression from TISSUES for CALM1 Gene
- Nervous system(5)
- Lung(4.5)
- Heart(4.3)
- Pancreas(4.3)
- Intestine(4.2)
- Muscle(4.2)
- Kidney(4.1)
- Skin(4)
- Blood(3.9)
- Eye(3.8)
- Liver(3.7)
- Adrenal gland(3.4)
- Stomach(3.4)
- Thyroid gland(3)
- Bone marrow(2.9)
- Spleen(2.9)
- Gall bladder(2.7)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CALM1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Regions:
Head and neck:
- brain
- ear
- head
Thorax:
- heart
- heart valve
- lung
Limb:
- lower limb
- upper limb
General:
- blood
- blood vessel
- red blood cell
Primer Products
-
OriGene qPCR primer pairs for CALM1
-
OriGene qPCR primer pairs and template standards for CALM1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALM1 Gene
Orthologs for CALM1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | CALM1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CALM1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Calm1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CALM1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CALM3 34 |
|
OneToOne | |
| CALM2 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | CALM 33 34 |
|
||
| chicken (Gallus gallus) |
Aves | CALM 34 |
|
OneToOne | |
| CALM1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | CALM1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.10372 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | calm3a 34 |
|
ManyToMany | |
| calm3b 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Cam 35 34 |
|
||
| And 35 |
|
|
|||
| CG11165 35 |
|
|
|||
| Mlc-c 35 |
|
|
|||
| TpnC41C 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | cmd-1 35 34 |
|
||
| Y73B3A.12 35 |
|
|
|||
| cal-6 34 |
|
ManyToMany | |||
| cal-1 35 |
|
|
|||
| cal-2 35 |
|
|
|||
| cal-3 35 |
|
|
|||
| cal-4 35 |
|
|
|||
| F12A10.5 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CMD1 36 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CAM7 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0687200 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10340 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04120 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cam1 33 |
|
- Species where no ortholog for CALM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CALM1 Gene
Paralogs for CALM1 Gene
(49) SIMAP similar genes for CALM1 Gene using alignment to 5 proteins:
- CALM2
- CALML3
- CALM3
- CALML5
- CETN1
- TNNC2
- CETN2
- TNNC1
- CALN1
- CABP1
- MYL9
- MYL12B
- CABP5
- CALML6
- CABP2
- MYL6
- MYL1
- MYL4
- MYL3
- MYL12A
- MYL5
- EFCAB2
- OCM
- MYL2
- CABP4
- NCALD
- CALML4
- OCM2
- CETN3
- MYLPF
- MYL10
- MYL6B
- HZGJ
- PPP3R1
- PPP3R2
- ACTN2
- AIF1
- PVALB
- ACTN4
- MYL7
- SLC25A24
- EFCAB7
- ACTN3
- ACTN1
- SPTAN1
- DUOX1
- GUCA1B
- DKFZp686E1183
- HPCAL1
Variants for CALM1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11551462 | Long QT syndrome 14 (LQT14) [MIM:616247] | p.Phe142Leu | |||
| rs139706811 | likely-benign, not specified, Long QT syndrome 14, Ventricular tachycardia, catecholaminergic polymorphic, 4 | 90,404,417(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs143503733 | benign, Long QT syndrome 14, Ventricular tachycardia, catecholaminergic polymorphic, 4 | 90,404,396(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs144339242 | likely-benign, Long QT syndrome 14, Ventricular tachycardia, catecholaminergic polymorphic, 4 | 90,401,293(+) | T/C | coding_sequence_variant, synonymous_variant | |
| rs199744595 | pathogenic, Long QT syndrome 14 | 90,404,693(+) | C/G/T | coding_sequence_variant, missense_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv983850 | CNV | duplication | 23825009 |
| nsv1131072 | CNV | deletion | 24896259 |
| nsv1069812 | CNV | deletion | 25765185 |
| esv3635309 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
53.6% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CALM1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALM1 Gene
Disorders for CALM1 Gene
(31) MalaCards diseases for CALM1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| long qt syndrome 14 |
|
|
| ventricular tachycardia, catecholaminergic polymorphic, 4 |
|
|
| catecholaminergic polymorphic ventricular tachycardia |
|
|
| long qt syndrome 1 |
|
|
| cardiac arrest |
|
|
Search CALM1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CALM1_HUMAN- Long QT syndrome 14 (LQT14) [MIM:616247]: A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269 PubMed:23388215, ECO:0000269 PubMed:24076290, ECO:0000269 PubMed:26164367, ECO:0000269 PubMed:26969752, ECO:0000269 PubMed:27165696}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
- Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant. {ECO:0000269 PubMed:23040497, ECO:0000269 PubMed:26164367, ECO:0000269 PubMed:27165696, ECO:0000269 PubMed:27516456}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.
Additional Disease Information for CALM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CALM1 Gene
Publications for CALM1 Gene
- Isolation and nucleotide sequence of a cDNA encoding human calmodulin. (PMID: 6385987) Wawrzynczak EJ … Perham RN (Biochemistry international 1984) 2 3 4 58
- Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G. (PMID: 26969752) Boczek NJ … Ackerman MJ (Circulation. Cardiovascular genetics 2016) 3 4 58
- Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. (PMID: 27516456) Gomez-Hurtado N … Knollmann BC (Circulation. Arrhythmia and electrophysiology 2016) 3 4 58
- Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex. (PMID: 27564677) Strulovich R … Hirsch JA (Biochemistry 2016) 3 4 58
- Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current. (PMID: 27165696) Yu CC … Chen PS (Heart rhythm 2016) 3 4 58
Products for CALM1 Gene
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- Custom Antibody ServicesOriGene Antibodies for CALM1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CALM1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALM1
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- OriGene qPCR primer pairs and template standards for CALM1
- OriGene qPCR primer pairs for CALM1
- OriGene CRISPR knockouts for CALM1
- OriGene ORF clones in human for CALM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for CALM1
- Cell Signaling Technology (CST) Antibodies for CALM1 (Calmodulin)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CALM1
- Browse Sino Biological Cell Lysates
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CALM1
- Novus Biologicals lysates and proteins for CALM1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CALM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CALM1
- VectorBuilder custom plasmid, inducible vectors for CALM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CALM1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CALM1
- Search GeneTex for Antibodies for CALM1
- Search GeneTex for Proteins for CALM1
- ViGene Biosciences adenoviral particle packaged cDNA for CALM1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CALM1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CALM1 gene
- Search ViGene Biosciences for CALM1
- Santa Cruz Biotechnology (SCBT) Antibodies for CALM1
- Search Santa Cruz Biotechnology (SCBT) for CALM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CALM1
- Horizon Cell Lines for CALM1
Sources for CALM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew