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Aliases for CALHM5 Gene

Aliases for CALHM5 Gene

  • Calcium Homeostasis Modulator Family Member 5 2 3 5
  • Family With Sequence Similarity 26 Member E 2 3
  • Protein FAM26E 3 4
  • C6orf188 3 4
  • FAM26E 3 4
  • Family With Sequence Similarity 26, Member E 2
  • Calcium Homeostasis Modulator Protein 5 3
  • Chromosome 6 Open Reading Frame 188 2
  • DJ493F7.3 3

External Ids for CALHM5 Gene

Previous HGNC Symbols for CALHM5 Gene

  • C6orf188
  • FAM26E

Summaries for CALHM5 Gene

GeneCards Summary for CALHM5 Gene

CALHM5 (Calcium Homeostasis Modulator Family Member 5) is a Protein Coding gene. An important paralog of this gene is CALHM6.

UniProtKB/Swiss-Prot for CALHM5 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

Additional gene information for CALHM5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM5 Gene

Genomics for CALHM5 Gene

GeneHancer (GH) Regulatory Elements for CALHM5 Gene

Promoters and enhancers for CALHM5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I116510 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 563.1 +0.6 601 2.6 PKNOX1 ATF1 ZNF2 IRF4 RAD21 ZBTB40 YY1 CHAMP1 ZNF335 ZNF213 CALHM5 TRAPPC3L CALHM6 RWDD1 CALHM4
GH06I116665 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 7.4 +155.9 155857 3.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZUFSP CALHM5 KPNA5 RWDD1 DSE GC06P116597
GH06I116528 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 7.4 +17.4 17366 1.8 SOX13 ZNF189 ZNF449 JUN HLF GFI1B PRDM6 KDM1A PRDM10 NFE2L2 CALHM4 RSPH4A ENSG00000237021 CALHM6 CALHM5 TRAPPC3L
GH06I116555 Enhancer 1 Ensembl ENCODE 9.2 +45.8 45757 3.6 PKNOX1 NFIB ZNF529 SIN3A ZNF366 SCRT2 RCOR1 CEBPB ELF1 ZEB2 RSPH4A KPNA5 CALHM6 CALHM4 ENSG00000244158 KRT18P22 CBX3P9 ENSG00000234117 CALHM5 TRAPPC3L
GH06I116475 Enhancer 1 Ensembl ENCODE 7.3 -35.7 -35727 1.8 ELF3 BMI1 BATF IRF4 RARA ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CALHM6 DSE CALHM5 ENSG00000244158 ENSG00000234117
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALHM5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CALHM5 Gene

Genomic Locations for CALHM5 Gene
13,148 bases
Plus strand

Genomic View for CALHM5 Gene

Genes around CALHM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM5 Gene

Proteins for CALHM5 Gene

  • Protein details for CALHM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis modulator protein 5
    Protein Accession:
    Secondary Accessions:
    • B2RDJ9
    • B3KSR3

    Protein attributes for CALHM5 Gene

    309 amino acids
    Molecular mass:
    35170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALHM5 Gene

Post-translational modifications for CALHM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALHM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALHM5 Gene

Domains & Families for CALHM5 Gene

Gene Families for CALHM5 Gene

Protein Domains for CALHM5 Gene


Suggested Antigen Peptide Sequences for CALHM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CALHM family.
  • Belongs to the CALHM family.
genes like me logo Genes that share domains with CALHM5: view

Function for CALHM5 Gene

Molecular function for CALHM5 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for CALHM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM5: view

Phenotypes for CALHM5 Gene

GenomeRNAi human phenotypes for CALHM5:
genes like me logo Genes that share phenotypes with CALHM5: view

miRNA for CALHM5 Gene

miRTarBase miRNAs that target CALHM5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALHM5 Gene

Localization for CALHM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM5 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALHM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with CALHM5: view

Pathways & Interactions for CALHM5 Gene

SuperPathways for CALHM5 Gene

No Data Available

Interacting Proteins for CALHM5 Gene

Gene Ontology (GO) - Biological Process for CALHM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM5: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM5 Gene

Drugs & Compounds for CALHM5 Gene

No Compound Related Data Available

Transcripts for CALHM5 Gene

mRNA/cDNA for CALHM5 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM5 Gene

No ASD Table

Relevant External Links for CALHM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALHM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CALHM5 Gene:

genes like me logo Genes that share expression patterns with CALHM5: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM5 Gene

Orthologs for CALHM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM26E 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia FAM26E 33 34
  • 87.49 (n)
(Bos Taurus)
Mammalia FAM26E 33 34
  • 87.27 (n)
(Rattus norvegicus)
Mammalia Fam26e 33
  • 84.9 (n)
(Mus musculus)
Mammalia Fam26e 33 16 34
  • 83.6 (n)
(Monodelphis domestica)
Mammalia FAM26E 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FAM26E 34
  • 57 (a)
(Gallus gallus)
Aves FAM26E 33 34
  • 69.52 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731009 33
  • 58.94 (n)
(Danio rerio)
Actinopterygii fam26e.1 33
  • 59.87 (n)
fam26e 34
  • 50 (a)
FAM26E (1 of 2) 34
  • 50 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 33 34
  • 40.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
Species where no ortholog for CALHM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM5 Gene

Gene Tree for CALHM5 (if available)
Gene Tree for CALHM5 (if available)

Paralogs for CALHM5 Gene

Paralogs for CALHM5 Gene

genes like me logo Genes that share paralogs with CALHM5: view

Variants for CALHM5 Gene

Sequence variations from dbSNP and Humsavar for CALHM5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000148544 -- 116,517,635(+) G/T 3_prime_UTR_variant
rs1000343394 -- 116,521,338(+) G/T 3_prime_UTR_variant
rs1000378580 -- 116,514,237(+) A/G intron_variant
rs1000543462 -- 116,521,197(+) A/G 3_prime_UTR_variant
rs1000914622 -- 116,520,958(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CALHM5 Gene

Variant ID Type Subtype PubMed ID
esv2663254 CNV deletion 23128226
esv3610471 CNV loss 21293372
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for CALHM5 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALHM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM5 Gene

Disorders for CALHM5 Gene

No disorders were found for CALHM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM5 Gene

Publications for CALHM5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 58

Products for CALHM5 Gene

Sources for CALHM5 Gene

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