Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CALHM4 Gene

Aliases for CALHM4 Gene

  • Calcium Homeostasis Modulator Family Member 4 2 3 5
  • Family With Sequence Similarity 26 Member D 2 3
  • Protein FAM26D 3 4
  • C6orf78 3 4
  • FAM26D 3 4
  • Family With Sequence Similarity 26, Member D 2
  • Calcium Homeostasis Modulator Protein 4 3
  • Chromosome 6 Open Reading Frame 78 2

External Ids for CALHM4 Gene

Previous HGNC Symbols for CALHM4 Gene

  • C6orf78
  • FAM26D

Summaries for CALHM4 Gene

GeneCards Summary for CALHM4 Gene

CALHM4 (Calcium Homeostasis Modulator Family Member 4) is a Protein Coding gene. An important paralog of this gene is CALHM2.

UniProtKB/Swiss-Prot for CALHM4 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

Additional gene information for CALHM4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM4 Gene

Genomics for CALHM4 Gene

GeneHancer (GH) Regulatory Elements for CALHM4 Gene

Promoters and enhancers for CALHM4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J116528 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +0.0 12 1.8 SOX13 ZNF189 JUN HLF GFI1B PRDM6 KDM1A PRDM10 CALHM4 RSPH4A CALHM6 CALHM5 TRAPPC3L
GH06J116539 Promoter 0.5 EPDnew 650.4 +10.7 10729 0.1 CALHM4 TRAPPC3L
GH06J116276 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 -249.8 -249814 5.6 HDGF FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 TSPYL1 PIR59102 DSE CALHM6 TSPYL4 CALHM4 TRAPPC3L KRT18P22 CBX3P9 ENSG00000244158
GH06J116369 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.2 -156.6 -156606 5.9 SIN3A ZNF2 YY1 ZNF121 GLIS2 ATF7 RUNX3 KLF13 SP3 REST DSE CALHM4 ENSG00000234117 TSPYL4 FRK RSPH4A PIR33476 ENSG00000285446
GH06J116384 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -139.5 -139543 9.7 PKNOX1 MZF1 BATF IRF4 ZNF366 ATF7 FOS ETV6 BCLAF1 IKZF2 DSE CALHM6 CALHM4 CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L TSPYL1 CALHM5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALHM4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CALHM4 Gene

Genomic Locations for CALHM4 Gene
32,125 bases
Plus strand

Genomic View for CALHM4 Gene

Genes around CALHM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM4 Gene

Proteins for CALHM4 Gene

  • Protein details for CALHM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis modulator protein 4
    Protein Accession:
    Secondary Accessions:
    • B0QZ25
    • B0QZ27
    • B4DTQ0
    • Q96MK0

    Protein attributes for CALHM4 Gene

    314 amino acids
    Molecular mass:
    35060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM4 Gene


neXtProt entry for CALHM4 Gene

Post-translational modifications for CALHM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CALHM4 Gene

Domains & Families for CALHM4 Gene

Gene Families for CALHM4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CALHM4 Gene


Suggested Antigen Peptide Sequences for CALHM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CALHM family.
  • Belongs to the CALHM family.
genes like me logo Genes that share domains with CALHM4: view

Function for CALHM4 Gene

Molecular function for CALHM4 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Phenotypes From GWAS Catalog for CALHM4 Gene

Gene Ontology (GO) - Molecular Function for CALHM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM4: view
genes like me logo Genes that share phenotypes with CALHM4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALHM4 Gene

Localization for CALHM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM4 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for CALHM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALHM4 Gene

Pathways & Interactions for CALHM4 Gene

SuperPathways for CALHM4 Gene

No Data Available

Interacting Proteins for CALHM4 Gene

Gene Ontology (GO) - Biological Process for CALHM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM4: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM4 Gene

Drugs & Compounds for CALHM4 Gene

No Compound Related Data Available

Transcripts for CALHM4 Gene

mRNA/cDNA for CALHM4 Gene

(9) Selected AceView cDNA sequences:
(13) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM4 Gene

No ASD Table

Relevant External Links for CALHM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALHM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CALHM4 Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM4 Gene

Orthologs for CALHM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM26D 34 33
  • 99.61 (n)
(Canis familiaris)
Mammalia FAM26D 34 33
  • 86.94 (n)
(Bos Taurus)
Mammalia FAM26D 34 33
  • 84.12 (n)
(Mus musculus)
Mammalia Fam26d 34 33
  • 80.51 (n)
Calhm4 16
(Rattus norvegicus)
Mammalia Fam26d 33
  • 80.31 (n)
(Monodelphis domestica)
Mammalia FAM26D 34
  • 35 (a)
(Gallus gallus)
Aves FAM26D 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 6 (a)
Species where no ortholog for CALHM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CALHM4 Gene

Gene Tree for CALHM4 (if available)
Gene Tree for CALHM4 (if available)
Evolutionary constrained regions (ECRs) for CALHM4: view image

Paralogs for CALHM4 Gene

Paralogs for CALHM4 Gene

genes like me logo Genes that share paralogs with CALHM4: view

Variants for CALHM4 Gene

Sequence variations from dbSNP and Humsavar for CALHM4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000057975 -- 116,528,385(+) G/A upstream_transcript_variant
rs1000100044 -- 116,554,642(+) T/A intron_variant
rs1000160627 -- 116,553,060(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000213322 -- 116,553,606(+) T/C 5_prime_UTR_variant, intron_variant
rs1000388554 -- 116,559,689(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CALHM4 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for CALHM4 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALHM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM4 Gene

Disorders for CALHM4 Gene

No disorders were found for CALHM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM4 Gene

Publications for CALHM4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CALHM4 Gene

Sources for CALHM4 Gene

Loading form....