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Aliases for CALHM3 Gene

Aliases for CALHM3 Gene

  • Calcium Homeostasis Modulator 3 2 3 5
  • Family With Sequence Similarity 26, Member A 2 3
  • FAM26A 3 4
  • Calcium Homeostasis Modulator Protein 3 3
  • Protein FAM26A 4
  • BA225H22.7 3

External Ids for CALHM3 Gene

Previous HGNC Symbols for CALHM3 Gene

  • FAM26A

Previous GeneCards Identifiers for CALHM3 Gene

  • GC10M105223
  • GC10M098863

Summaries for CALHM3 Gene

GeneCards Summary for CALHM3 Gene

CALHM3 (Calcium Homeostasis Modulator 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cation channel activity. An important paralog of this gene is CALHM1.

UniProtKB/Swiss-Prot for CALHM3 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

Additional gene information for CALHM3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM3 Gene

Genomics for CALHM3 Gene

GeneHancer (GH) Regulatory Elements for CALHM3 Gene

Promoters and enhancers for CALHM3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J103479 Promoter/Enhancer 1.2 EPDnew ENCODE 650.7 -0.3 -285 0.9 KLF1 PKNOX1 JUN KLF17 E4F1 CTBP1 GLIS2 ZNF316 RCOR1 FOSL2 CALHM3 AS3MT NEURL1 NEURL1-AS1
GH10J103480 Enhancer 0.4 ENCODE 650.7 -1.5 -1460 0.8 NFIC NFIA SCRT2 CALHM3 CALHM2 AS3MT NEURL1 NEURL1-AS1
GH10J103490 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.4 -13.2 -13176 4 PKNOX1 SIN3A ZNF2 GLIS2 ZNF207 ATF7 FOS RUNX3 SP3 YY2 NEURL1 CALHM1 PCGF6 NEURL1-AS1 PDCD11 CALHM3
GH10J103482 Enhancer 1 ENCODE dbSUPER 0.7 -2.9 -2869 0.2 HDGF FOXA2 ZNF48 RAD21 ARID2 ZNF143 BCLAF1 SMARCA5 ZNF654 REST CALHM3 NEURL1 NEURL1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALHM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALHM3 gene promoter:

Genomic Locations for CALHM3 Gene

Genomic Locations for CALHM3 Gene
6,437 bases
Minus strand

Genomic View for CALHM3 Gene

Genes around CALHM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM3 Gene

Proteins for CALHM3 Gene

  • Protein details for CALHM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis modulator protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5W090
    • Q8IXR2

    Protein attributes for CALHM3 Gene

    350 amino acids
    Molecular mass:
    39087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM3 Gene


neXtProt entry for CALHM3 Gene

Post-translational modifications for CALHM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALHM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALHM3 Gene

Domains & Families for CALHM3 Gene

Gene Families for CALHM3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CALHM3 Gene


Suggested Antigen Peptide Sequences for CALHM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CALHM family.
  • Belongs to the CALHM family.
genes like me logo Genes that share domains with CALHM3: view

Function for CALHM3 Gene

Molecular function for CALHM3 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Phenotypes From GWAS Catalog for CALHM3 Gene

Gene Ontology (GO) - Molecular Function for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM3: view
genes like me logo Genes that share phenotypes with CALHM3: view

Animal Model Products

miRNA for CALHM3 Gene

miRTarBase miRNAs that target CALHM3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALHM3 Gene

Localization for CALHM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM3: view

Pathways & Interactions for CALHM3 Gene

SuperPathways for CALHM3 Gene

No Data Available

Interacting Proteins for CALHM3 Gene

Gene Ontology (GO) - Biological Process for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM3: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM3 Gene

Drugs & Compounds for CALHM3 Gene

No Compound Related Data Available

Transcripts for CALHM3 Gene

mRNA/cDNA for CALHM3 Gene

(7) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALHM3 Gene

Calcium homeostasis modulator 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM3 Gene

No ASD Table

Relevant External Links for CALHM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALHM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALHM3 Gene

mRNA differential expression in normal tissues according to GTEx for CALHM3 Gene

This gene is overexpressed in Testis (x6.4) and Pancreas (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of CALHM3 Gene:


SOURCE GeneReport for Unigene cluster for CALHM3 Gene:


mRNA Expression by UniProt/SwissProt for CALHM3 Gene:

Tissue specificity: Specifically expressed in circumvallate taste bud cells.
genes like me logo Genes that share expression patterns with CALHM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM3 Gene

Orthologs for CALHM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALHM3 34 33
  • 99.22 (n)
(Bos Taurus)
Mammalia CALHM3 34 33
  • 88.28 (n)
(Canis familiaris)
Mammalia CALHM3 34 33
  • 87.79 (n)
(Mus musculus)
Mammalia Calhm3 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Calhm3 33
  • 82.95 (n)
(Ornithorhynchus anatinus)
Mammalia CALHM3 34
  • 68 (a)
(Monodelphis domestica)
Mammalia CALHM3 34
  • 66 (a)
(Gallus gallus)
Aves CALHM3 34 33
  • 67.6 (n)
(Anolis carolinensis)
Reptilia CALHM3 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489522 33
  • 64.63 (n)
(Danio rerio)
Actinopterygii calhm3 34 33
  • 56.47 (n)
(Caenorhabditis elegans)
Secernentea clhm-1 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
Species where no ortholog for CALHM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM3 Gene

Gene Tree for CALHM3 (if available)
Gene Tree for CALHM3 (if available)
Evolutionary constrained regions (ECRs) for CALHM3: view image

Paralogs for CALHM3 Gene

Paralogs for CALHM3 Gene

(2) SIMAP similar genes for CALHM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALHM3: view

Variants for CALHM3 Gene

Sequence variations from dbSNP and Humsavar for CALHM3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000954462 -- 103,479,210(-) G/A/C 5_prime_UTR_variant
rs1001008224 -- 103,479,607(-) C/G upstream_transcript_variant
rs1001562961 -- 103,473,378(-) G/A/T coding_sequence_variant, synonymous_variant
rs1001953464 -- 103,480,818(-) C/T upstream_transcript_variant
rs1002002759 -- 103,481,068(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CALHM3 Gene

Variant ID Type Subtype PubMed ID
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
nsv518987 CNV loss 19592680
nsv524966 CNV loss 19592680

Variation tolerance for CALHM3 Gene

Gene Damage Index Score: 7.29; 81.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALHM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM3 Gene

Disorders for CALHM3 Gene

Additional Disease Information for CALHM3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CALHM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM3 Gene

Publications for CALHM3 Gene

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PMID: 18585350) Dreses-Werringloer U … Marambaud P (Cell 2008) 2 3 4 58
  2. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. (PMID: 20164573) Shibata N … Arai H (Journal of Alzheimer's disease : JAD 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CALHM3 Gene

Sources for CALHM3 Gene

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