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Aliases for CALHM2 Gene

Aliases for CALHM2 Gene

  • Calcium Homeostasis Modulator Family Member 2 2 3 5
  • Family With Sequence Similarity 26, Member B 2 3
  • Calcium Homeostasis Modulator 2 2 3
  • FAM26B 3 4
  • Calcium Homeostasis Modulator Protein 2 3
  • Protein FAM26B 4

External Ids for CALHM2 Gene

Previous HGNC Symbols for CALHM2 Gene

  • FAM26B

Previous GeneCards Identifiers for CALHM2 Gene

  • GC10M105197
  • GC10M105206
  • GC10M098837

Summaries for CALHM2 Gene

GeneCards Summary for CALHM2 Gene

CALHM2 (Calcium Homeostasis Modulator Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cation channel activity. An important paralog of this gene is CALHM5.

UniProtKB/Swiss-Prot for CALHM2 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

Additional gene information for CALHM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM2 Gene

Genomics for CALHM2 Gene

GeneHancer (GH) Regulatory Elements for CALHM2 Gene

Promoters and enhancers for CALHM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J103448 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 654.7 +1.6 1562 5 PKNOX1 NFIB KLF17 SIN3A NFXL1 BRCA1 RFX5 GLIS2 EGR1 SCRT2 CALHM2 ENSG00000273485 ENSG00000260461 SUFU PDCD11 ENSG00000234699
GH10J103367 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 +84.2 84150 2.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 TAF5 PDCD11 SFXN2 SLK ENSG00000260461 CALHM2 GC10P103388
GH10J102772 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +673.7 673719 11.8 PKNOX1 FOXA2 SIN3A YY1 ZNF121 GLIS2 FOS RUNX3 RXRA REST WBP1L SFXN2 AS3MT ARL3 PPRC1 NFKB2 LDB1 PDCD11 BORCS7 CYP17A1
GH10J103692 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -240.3 -240335 1.5 HDGF PKNOX1 ZNF133 ZNF2 IRF4 GLIS2 ZNF416 ZNF207 ZNF143 ATF7 ENSG00000260461 LOC105378464 LOC101927523 SORCS3-AS1 SFR1 SLK PDCD11 CALHM2 PCGF6 STN1
GH10J102798 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +650.6 650632 5.7 USF1 JUN MAX EBF1 RAD21 YY1 RELA POLR2A FOS ETV6 NFKB2 PPRC1 BORCS7 PDCD11 AS3MT CALHM2 LDB1 WBP1L SFXN2 NT5C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALHM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALHM2 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • Pax-5
  • LCR-F1
  • AhR
  • GATA-2
  • HEN1
  • YY1
  • Pax-2

Genomic Locations for CALHM2 Gene

Genomic Locations for CALHM2 Gene
5,621 bases
Minus strand
6,118 bases
Minus strand

Genomic View for CALHM2 Gene

Genes around CALHM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM2 Gene

Proteins for CALHM2 Gene

  • Protein details for CALHM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis modulator protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DR94
    • O95893
    • Q6ZUV9

    Protein attributes for CALHM2 Gene

    323 amino acids
    Molecular mass:
    36175 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM2 Gene


neXtProt entry for CALHM2 Gene

Post-translational modifications for CALHM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CALHM2 Gene

Domains & Families for CALHM2 Gene

Gene Families for CALHM2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CALHM2 Gene


Suggested Antigen Peptide Sequences for CALHM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CALHM family.
  • Belongs to the CALHM family.
genes like me logo Genes that share domains with CALHM2: view

Function for CALHM2 Gene

Molecular function for CALHM2 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Phenotypes From GWAS Catalog for CALHM2 Gene

Gene Ontology (GO) - Molecular Function for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM2: view
genes like me logo Genes that share phenotypes with CALHM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CALHM2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALHM2 Gene

Localization for CALHM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM2: view

Pathways & Interactions for CALHM2 Gene

SuperPathways for CALHM2 Gene

No Data Available

Interacting Proteins for CALHM2 Gene

Selected Interacting proteins: Q9HA72-CAHM2_HUMAN for CALHM2 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM2: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM2 Gene

Drugs & Compounds for CALHM2 Gene

No Compound Related Data Available

Transcripts for CALHM2 Gene

Unigene Clusters for CALHM2 Gene

Calcium homeostasis modulator 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - - - - - -
SP13: - - - - - - -

Relevant External Links for CALHM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALHM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALHM2 Gene

Protein differential expression in normal tissues from HIPED for CALHM2 Gene

This gene is overexpressed in Uterus (24.7), Pancreas (13.6), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALHM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CALHM2 Gene:


SOURCE GeneReport for Unigene cluster for CALHM2 Gene:


Evidence on tissue expression from TISSUES for CALHM2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CALHM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM2 Gene

Orthologs for CALHM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALHM2 34 33
  • 99.48 (n)
(Bos Taurus)
Mammalia CALHM2 34 33
  • 89.78 (n)
(Canis familiaris)
Mammalia CALHM2 34 33
  • 89.78 (n)
(Rattus norvegicus)
Mammalia Calhm2 33
  • 87.75 (n)
(Mus musculus)
Mammalia Calhm2 16 34 33
  • 87.33 (n)
(Monodelphis domestica)
Mammalia CALHM2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia CALHM2 34
  • 85 (a)
(Gallus gallus)
Aves CALHM2 34 33
  • 77.74 (n)
(Anolis carolinensis)
Reptilia CALHM2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia calhm2 33
  • 65.83 (n)
MGC76165 33
(Danio rerio)
Actinopterygii calhm2 34 33
  • 60.85 (n)
CALHM2 (2 of 2) 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 14 (a)
Species where no ortholog for CALHM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM2 Gene

Gene Tree for CALHM2 (if available)
Gene Tree for CALHM2 (if available)
Evolutionary constrained regions (ECRs) for CALHM2: view image

Paralogs for CALHM2 Gene

Paralogs for CALHM2 Gene

(4) SIMAP similar genes for CALHM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALHM2: view

Variants for CALHM2 Gene

Sequence variations from dbSNP and Humsavar for CALHM2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000036322 -- 103,448,308(-) G/A intron_variant
rs1000409972 -- 103,450,555(-) G/A 5_prime_UTR_variant, intron_variant
rs1000494063 -- 103,447,958(-) AT/ intron_variant
rs1000905244 -- 103,452,720(-) G/T upstream_transcript_variant
rs1001108417 -- 103,446,768(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CALHM2 Gene

Variant ID Type Subtype PubMed ID
dgv280e212 CNV gain 25503493
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
esv3624413 CNV gain 21293372
esv3624414 CNV gain 21293372
nsv1047382 CNV gain 25217958
nsv518987 CNV loss 19592680
nsv524966 CNV loss 19592680
nsv552060 CNV loss 21841781

Variation tolerance for CALHM2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALHM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM2 Gene

Disorders for CALHM2 Gene

Additional Disease Information for CALHM2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CALHM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM2 Gene

Publications for CALHM2 Gene

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PMID: 18585350) Dreses-Werringloer U … Marambaud P (Cell 2008) 2 3 4 58
  2. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. (PMID: 20164573) Shibata N … Arai H (Journal of Alzheimer's disease : JAD 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for CALHM2 Gene

Sources for CALHM2 Gene

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