Aliases for CALCRL Gene
External Ids for CALCRL Gene
Previous GeneCards Identifiers for CALCRL Gene
GeneCards Summary for CALCRL Gene
CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Lymphatic Malformation 8 and Primary Angle-Closure Glaucoma. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.
UniProtKB/Swiss-Prot Summary for CALCRL Gene
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.