Aliases for CALCRL Gene

Aliases for CALCRL Gene

  • Calcitonin Receptor Like Receptor 2 3 5
  • CGRPR 2 3 4
  • Calcitonin Gene-Related Peptide Type 1 Receptor 3 4
  • Calcitonin Receptor-Like 2 3
  • CGRP Type 1 Receptor 3 4
  • CRLR 2 3
  • Calcitonin Receptor-Like Receptor 4
  • LMPHM8 3
  • CALCRL 5

External Ids for CALCRL Gene

Previous GeneCards Identifiers for CALCRL Gene

  • GC02M186419
  • GC02M186892
  • GC02M188171
  • GC02M188412
  • GC02M188035
  • GC02M187918
  • GC02M180067

Summaries for CALCRL Gene

GeneCards Summary for CALCRL Gene

CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Lymphatic Malformation 8 and Primary Angle-Closure Glaucoma. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.

UniProtKB/Swiss-Prot Summary for CALCRL Gene

  • Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for CALCRL Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCRL Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALCRL Gene

Genomics for CALCRL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CALCRL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J187445 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 617.5 +2.2 2159 5.4 POLR2A ZNF7 STAT3 SMAD5 RAD21 IKZF2 TRIM22 HDAC1 GABPA SOX6 CALCRL lnc-TFPI-1 GAPDHP59 LOC105373786 ENSG00000224063 ZSWIM2
GH02J187539 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 -98.8 -98779 16.2 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 ZNF512 LEF1 SOX13 IKZF1 TFPI CALCRL ZSWIM2 GAPDHP59 ST13P2 lnc-CALCRL-2 piR-39781-017 LOC105373786 ENSG00000224063
GH02J187516 Enhancer 0.8 ENCODE 27.3 -68.2 -68233 1.2 IKZF1 ZNF24 NR2C1 DPF2 SOX6 TCF12 EP300 MGA HMBOX1 POLR2A piR-39781-017 CALCRL TFPI lnc-CALCRL-2 LOC105373786 ENSG00000224063
GH02J187423 Enhancer 0.6 Ensembl ENCODE dbSUPER 27.6 +24.8 24759 4.2 CEBPB CALCRL FAM171B TFPI GAPDHP59 lnc-TFPI-1 LOC105373786 ENSG00000224063 ZSWIM2
GH02J187136 Enhancer 0.5 Ensembl 33.3 +311.3 311260 3.2 CTCF RAD21 SMC3 ZNF143 YY1 CALCRL RN7SKP42 lnc-CALCRL-3 piR-53003 ENSG00000224063 ZSWIM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALCRL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALCRL

Top Transcription factor binding sites by QIAGEN in the CALCRL gene promoter:
  • ATF-2
  • Chx10
  • CREB
  • deltaCREB
  • GATA-1
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • STAT1

Genomic Locations for CALCRL Gene

Genomic Locations for CALCRL Gene
chr2:187,341,964-187,448,460
(GRCh38/hg38)
Size:
106,497 bases
Orientation:
Minus strand
chr2:188,207,846-188,313,187
(GRCh37/hg19)
Size:
105,342 bases
Orientation:
Minus strand

Genomic View for CALCRL Gene

Genes around CALCRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCRL Gene

Proteins for CALCRL Gene

  • Protein details for CALCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16602-CALRL_HUMAN
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Protein Accession:
    Q16602
    Secondary Accessions:
    • A8K6G5
    • A8KAD3
    • Q53S02
    • Q53TS5

    Protein attributes for CALCRL Gene

    Size:
    461 amino acids
    Molecular mass:
    52929 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.
    SequenceCaution:
    • Sequence=BAF84319.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALCRL Gene

neXtProt entry for CALCRL Gene

Post-translational modifications for CALCRL Gene

  • Glycosylation at Asn66, Asn118, and Asn123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CALCRL Gene

Domains & Families for CALCRL Gene

Gene Families for CALCRL Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CALCRL Gene

InterPro:
Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
  • Calcitonin receptor family signature
  • Calcitonin gene-related peptide type 1 receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for CALCRL Gene

GenScript: Design optimal peptide antigens:
  • Calcitonin receptor-like receptor (CALRL_HUMAN)
  • Calcitonin receptor-like, isoform CRA_a (D3DPG9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16602

UniProtKB/Swiss-Prot:

CALRL_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCRL: view

Function for CALCRL Gene

Molecular function for CALCRL Gene

UniProtKB/Swiss-Prot Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Phenotypes From GWAS Catalog for CALCRL Gene

Gene Ontology (GO) - Molecular Function for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001605 adrenomedullin receptor activity IBA,IPI 9620797
GO:0001635 calcitonin gene-related peptide receptor activity IBA,IPI 9620797
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA,TAS 7818539
GO:0004948 calcitonin receptor activity IEA --
genes like me logo Genes that share ontologies with CALCRL: view
genes like me logo Genes that share phenotypes with CALCRL: view

Animal Models for CALCRL Gene

MGI Knock Outs for CALCRL:

Animal Model Products

CRISPR Products

miRNA for CALCRL Gene

miRTarBase miRNAs that target CALCRL

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALCRL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCRL Gene

Localization for CALCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCRL Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCRL gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 5
lysosome 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10882736
GO:0005764 lysosome IDA 10882736
GO:0005768 endosome IDA 10882736
GO:0005783 endoplasmic reticulum IDA 10882736
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CALCRL: view

Pathways & Interactions for CALCRL Gene

genes like me logo Genes that share pathways with CALCRL: view

Gene Ontology (GO) - Biological Process for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA,IDA 20596610
GO:0006816 calcium ion transport IDA 10882736
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with CALCRL: view

No data available for SIGNOR curated interactions for CALCRL Gene

Drugs & Compounds for CALCRL Gene

(17) Drugs for CALCRL Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Erenumab Approved, Investigational Pharma Target 42
Rimegepant Approved, Investigational Pharma Target, antagonist 0
Ubrogepant Approved, Investigational Pharma Target, antagonist 0
Olcegepant Investigational Pharma Target Non-peptide receptor of CGRP,first potent and selective 0
Telcagepant Investigational Pharma Target CGRP receptor antagonist 0

(4) Additional Compounds for CALCRL Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1

(5) Tocris Compounds for CALCRL Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6

(1) ApexBio Compounds for CALCRL Gene

Compound Action Cas Number
MK-3207 HCl 0 957116-20-0
genes like me logo Genes that share compounds with CALCRL: view

Drug Products

Transcripts for CALCRL Gene

mRNA/cDNA for CALCRL Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALCRL

Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - -
SP10:
SP11: - - - -

Relevant External Links for CALCRL Gene

GeneLoc Exon Structure for
CALCRL

Expression for CALCRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CALCRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCRL Gene

This gene is overexpressed in Lung (x6.1) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for CALCRL Gene

This gene is overexpressed in Lung (38.1) and Spinal cord (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALCRL Gene



Protein tissue co-expression partners for CALCRL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALCRL

SOURCE GeneReport for Unigene cluster for CALCRL Gene:

Hs.470882

mRNA Expression by UniProt/SwissProt for CALCRL Gene:

Q16602-CALRL_HUMAN
Tissue specificity: Predominantly expressed in the lung and heart.

Evidence on tissue expression from TISSUES for CALCRL Gene

  • Nervous system(4.6)
  • Heart(4.6)
  • Lung(4.5)
  • Muscle(2.8)
  • Thyroid gland(2.6)
  • Kidney(2.6)
  • Bone(2.2)
  • Intestine(2.2)
  • Adrenal gland(2.1)
  • Blood(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CALCRL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCRL Gene

Orthologs for CALCRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCRL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CALCRL 30 31
  • 99.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CALCRL 30 31
  • 90.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CALCRL 30 31
  • 90.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Calcrl 30
  • 86.23 (n)
Mouse
(Mus musculus)
Mammalia Calcrl 30 17 31
  • 85.36 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CALCRL 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CALCRL 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CALCRL 30 31
  • 77.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CALCRL 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia calcrl 30
  • 74.55 (n)
Str.12334 30
African clawed frog
(Xenopus laevis)
Amphibia calcrl-prov 30
Zebrafish
(Danio rerio)
Actinopterygii calcrla 30 31
  • 69.32 (n)
OneToMany
calcrlb 31
  • 63 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Dh31-R1 30 31
  • 50.28 (n)
ManyToMany
EG:BACR25B3.3 32
  • 28 (a)
hec 31
  • 27 (a)
ManyToMany
Pdfr 31
  • 19 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCAL1 30
  • 49.32 (n)
Worm
(Caenorhabditis elegans)
Secernentea pdfr-1 31
  • 21 (a)
OneToMany
Species where no ortholog for CALCRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CALCRL Gene

ENSEMBL:
Gene Tree for CALCRL (if available)
TreeFam:
Gene Tree for CALCRL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CALCRL: view image

Paralogs for CALCRL Gene

(9) SIMAP similar genes for CALCRL Gene using alignment to 4 proteins:

  • CALRL_HUMAN
  • B8ZZJ4_HUMAN
  • D3DPG9_HUMAN
  • E7EN01_HUMAN
genes like me logo Genes that share paralogs with CALCRL: view

Variants for CALCRL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALCRL Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
778263 Benign: not provided 187,346,278(-) C/A MISSENSE_VARIANT
789709 Benign: not provided 187,360,602(-) G/A SYNONYMOUS_VARIANT
812514 Pathogenic: LYMPHATIC MALFORMATION 8 187,363,386(-) GCTA/G INFRAME_DELETION
rs13391909 - p.Phe16Leu
rs34010553 - p.Arg274Ile

Additional dbSNP identifiers (rs#s) for CALCRL Gene

Structural Variations from Database of Genomic Variants (DGV) for CALCRL Gene

Variant ID Type Subtype PubMed ID
dgv2113n106 CNV deletion 24896259
dgv4132n100 CNV loss 25217958
esv1009899 CNV deletion 20482838
esv1045156 CNV deletion 17803354
esv2249015 CNV deletion 18987734
esv2721246 CNV deletion 23290073
esv2840124 CNV deletion 24192839
esv3033 CNV loss 18987735
esv3560691 CNV deletion 23714750
esv3593690 CNV loss 21293372
esv6916 CNV loss 19470904
esv992040 CNV deletion 20482838
nsv1011800 CNV loss 25217958
nsv1073001 CNV deletion 25765185
nsv1160891 CNV duplication 26073780
nsv459989 CNV loss 19166990
nsv474198 CNV novel sequence insertion 20440878
nsv517687 CNV loss 19592680
nsv584036 CNV loss 21841781
nsv584037 CNV loss 21841781
nsv834487 CNV gain 17160897
nsv834488 CNV gain+loss 17160897
nsv954711 CNV deletion 24416366
nsv979157 CNV duplication 23825009

Variation tolerance for CALCRL Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALCRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCRL Gene

Disorders for CALCRL Gene

MalaCards: The human disease database

(12) MalaCards diseases for CALCRL Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphatic malformation 8
  • lmphm8
primary angle-closure glaucoma
  • primary angle closure glaucoma
pheochromocytoma
  • pcc
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
acute closed-angle glaucoma
  • acute angle-closure glaucoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CALCRL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CALCRL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCRL Gene

Publications for CALCRL Gene

  1. Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. (PMID: 19898635) Cao D … Mao Z (Molecular vision 2009) 3 23 41
  2. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L … Lioté F (Clinical and experimental rheumatology 2008) 3 23 41
  3. Association study of calcitonin-receptor-like receptor gene in essential hypertension. (PMID: 15797661) Sano M … Kokubun S (American journal of hypertension 2005) 3 23 41
  4. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PMID: 8626685) Aiyar N … Li Y (The Journal of biological chemistry 1996) 2 3 4
  5. A human orphan calcitonin receptor-like structure. (PMID: 7818539) Flühmann B … Born W (Biochemical and biophysical research communications 1995) 2 3 4

Products for CALCRL Gene

  • Signalway ELISA kits for CALCRL
  • Signalway Proteins for CALCRL

Sources for CALCRL Gene