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Aliases for CALCRL Gene

Aliases for CALCRL Gene

  • Calcitonin Receptor Like Receptor 2 3 5
  • Calcitonin Receptor-Like 2 3
  • CGRP Type 1 Receptor 3 4
  • CGRPR 3 4
  • Calcitonin Gene-Related Peptide Type 1 Receptor 3
  • Calcitonin Receptor-Like Receptor 4
  • CRLR 3

External Ids for CALCRL Gene

Previous GeneCards Identifiers for CALCRL Gene

  • GC02M186419
  • GC02M186892
  • GC02M188171
  • GC02M188412
  • GC02M188035
  • GC02M187918
  • GC02M180067

Summaries for CALCRL Gene

GeneCards Summary for CALCRL Gene

CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Migraine With Or Without Aura 1 and Pheochromocytoma. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.

UniProtKB/Swiss-Prot for CALCRL Gene

  • Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for CALCRL Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCRL Gene

Additional gene information for CALCRL Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCRL Gene

Genomics for CALCRL Gene

GeneHancer (GH) Regulatory Elements for CALCRL Gene

Promoters and enhancers for CALCRL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J187445 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 667.5 +1.4 1442 3.8 HDAC1 PKNOX1 ATF1 SMAD1 RB1 RAD21 ATF7 IKZF2 BCLAF1 CREM CALCRL GAPDHP59 GC02P187416 LOC105373786
GH02J187539 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.7 -98.8 -98779 16.2 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TFPI CALCRL ZSWIM2 GAPDHP59 ST13P2 GC02M187465 LOC105373786
GH02J187516 Enhancer 0.8 ENCODE 27.3 -68.2 -68233 1.2 HDAC1 ARNT NCOA2 CHAMP1 TCF12 CBX5 EGR1 ATF7 CEBPB NCOA1 CALCRL TFPI GC02M187465 LOC105373786
GH02J187402 Enhancer 1 Ensembl ENCODE dbSUPER 15 +44.3 44272 3.4 SMARCA5 BACH1 MAFG PAX8 EBF1 MEF2B ZNF316 POLR2A IKZF1 NFE2 CALCRL GAPDHP59 RNU6-989P GC02M187271 LOC105373786
GH02J187526 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 -80.3 -80310 5.2 FOXA2 SIN3A FEZF1 ETS1 YY1 SLC30A9 FOS NFKBIZ PAF1 RXRA TFPI CALCRL FAM171B GC02M187465 LOC105373786
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALCRL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALCRL gene promoter:
  • deltaCREB
  • CREB
  • Chx10
  • ATF-2
  • SRF
  • SRF (504 AA)
  • GATA-1
  • POU2F1a
  • POU2F1
  • STAT1

Genomic Locations for CALCRL Gene

Genomic Locations for CALCRL Gene
106,498 bases
Minus strand
105,342 bases
Minus strand

Genomic View for CALCRL Gene

Genes around CALCRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCRL Gene

Proteins for CALCRL Gene

  • Protein details for CALCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Protein Accession:
    Secondary Accessions:
    • A8K6G5
    • A8KAD3
    • Q53S02
    • Q53TS5

    Protein attributes for CALCRL Gene

    461 amino acids
    Molecular mass:
    52929 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.
    • Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALCRL Gene

neXtProt entry for CALCRL Gene

Post-translational modifications for CALCRL Gene

  • Glycosylation at posLast=123123, Asn118, and Asn66
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CALCRL Gene

Domains & Families for CALCRL Gene

Gene Families for CALCRL Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Suggested Antigen Peptide Sequences for CALCRL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCRL: view

Function for CALCRL Gene

Molecular function for CALCRL Gene

UniProtKB/Swiss-Prot Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Phenotypes From GWAS Catalog for CALCRL Gene

Gene Ontology (GO) - Molecular Function for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001605 adrenomedullin receptor activity IPI 9620797
GO:0001635 calcitonin gene-related peptide receptor activity IPI 9620797
GO:0004871 obsolete signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA 7818539
genes like me logo Genes that share ontologies with CALCRL: view
genes like me logo Genes that share phenotypes with CALCRL: view

Animal Models for CALCRL Gene

MGI Knock Outs for CALCRL:

Animal Model Products

miRNA for CALCRL Gene

miRTarBase miRNAs that target CALCRL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCRL Gene

Localization for CALCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCRL Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCRL gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 5
endosome 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10882736
GO:0005764 lysosome IDA 10882736
GO:0005768 endosome IDA 10882736
GO:0005783 endoplasmic reticulum IDA 10882736
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CALCRL: view

Pathways & Interactions for CALCRL Gene

genes like me logo Genes that share pathways with CALCRL: view

Gene Ontology (GO) - Biological Process for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006816 calcium ion transport IDA 10882736
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with CALCRL: view

No data available for SIGNOR curated interactions for CALCRL Gene

Drugs & Compounds for CALCRL Gene

(14) Drugs for CALCRL Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Erenumab Approved, Investigational Pharma Target 0
Olcegepant Investigational Pharma Target Non-peptide receptor of CGRP,first potent and selective 0
Telcagepant Investigational Pharma Target CGRP receptor antagonist 0
MK-3207 HCl Pharma 0 0
CGRP Pharma 0

(4) Additional Compounds for CALCRL Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
Calcitonin (salmon)

(5) Tocris Compounds for CALCRL Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with CALCRL: view

Transcripts for CALCRL Gene


Unigene Clusters for CALCRL Gene

Calcitonin receptor-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - -
SP11: - - - -

Relevant External Links for CALCRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALCRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALCRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCRL Gene

This gene is overexpressed in Lung (x6.1) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for CALCRL Gene

This gene is overexpressed in Lung (38.1) and Spinal cord (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALCRL Gene

Protein tissue co-expression partners for CALCRL Gene

NURSA nuclear receptor signaling pathways regulating expression of CALCRL Gene:


SOURCE GeneReport for Unigene cluster for CALCRL Gene:


mRNA Expression by UniProt/SwissProt for CALCRL Gene:

Tissue specificity: Predominantly expressed in the lung and heart.

Evidence on tissue expression from TISSUES for CALCRL Gene

  • Heart(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Muscle(2.6)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with CALCRL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCRL Gene

Orthologs for CALCRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCRL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALCRL 34 33
  • 99.86 (n)
(Bos Taurus)
Mammalia CALCRL 34 33
  • 90.53 (n)
(Canis familiaris)
Mammalia CALCRL 34 33
  • 90.09 (n)
(Rattus norvegicus)
Mammalia Calcrl 33
  • 86.23 (n)
(Mus musculus)
Mammalia Calcrl 16 34 33
  • 85.36 (n)
(Monodelphis domestica)
Mammalia CALCRL 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CALCRL 34
  • 68 (a)
(Gallus gallus)
Aves CALCRL 34 33
  • 77.2 (n)
(Anolis carolinensis)
Reptilia CALCRL 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia calcrl 33
  • 74.55 (n)
Str.12334 33
African clawed frog
(Xenopus laevis)
Amphibia calcrl-prov 33
(Danio rerio)
Actinopterygii calcrla 34 33
  • 69.32 (n)
calcrlb 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dh31-R1 34 33
  • 50.28 (n)
EG:BACR25B3.3 35
  • 28 (a)
hec 34
  • 27 (a)
Pdfr 34
  • 19 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCAL1 33
  • 49.32 (n)
(Caenorhabditis elegans)
Secernentea pdfr-1 34
  • 21 (a)
Species where no ortholog for CALCRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCRL Gene

Gene Tree for CALCRL (if available)
Gene Tree for CALCRL (if available)
Evolutionary constrained regions (ECRs) for CALCRL: view image

Paralogs for CALCRL Gene

Paralogs for CALCRL Gene

(9) SIMAP similar genes for CALCRL Gene using alignment to 4 proteins:

  • E7EN01_HUMAN
genes like me logo Genes that share paralogs with CALCRL: view

Variants for CALCRL Gene

Sequence variations from dbSNP and Humsavar for CALCRL Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000032197 -- 187,381,496(-) C/T intron_variant
rs1000036915 -- 187,372,005(-) T/C intron_variant
rs1000089119 -- 187,419,210(-) A/G intron_variant
rs1000131087 -- 187,421,452(-) C/G intron_variant
rs1000141803 -- 187,374,354(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CALCRL Gene

Variant ID Type Subtype PubMed ID
dgv2113n106 CNV deletion 24896259
dgv4132n100 CNV loss 25217958
esv1009899 CNV deletion 20482838
esv1045156 CNV deletion 17803354
esv2249015 CNV deletion 18987734
esv2721246 CNV deletion 23290073
esv2840124 CNV deletion 24192839
esv3033 CNV loss 18987735
esv3560691 CNV deletion 23714750
esv3593690 CNV loss 21293372
esv6916 CNV loss 19470904
esv992040 CNV deletion 20482838
nsv1011800 CNV loss 25217958
nsv1073001 CNV deletion 25765185
nsv1160891 CNV duplication 26073780
nsv459989 CNV loss 19166990
nsv474198 CNV novel sequence insertion 20440878
nsv517687 CNV loss 19592680
nsv584036 CNV loss 21841781
nsv584037 CNV loss 21841781
nsv834487 CNV gain 17160897
nsv834488 CNV gain+loss 17160897
nsv954711 CNV deletion 24416366
nsv979157 CNV duplication 23825009

Variation tolerance for CALCRL Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALCRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCRL Gene

Disorders for CALCRL Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALCRL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
  • pheochromocytoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CALCRL

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CALCRL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCRL Gene

Publications for CALCRL Gene

  1. Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. (PMID: 19898635) Cao D … Mao Z (Molecular vision 2009) 3 22 44 58
  2. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L … Lioté F (Clinical and experimental rheumatology 2008) 3 22 44 58
  3. Association study of calcitonin-receptor-like receptor gene in essential hypertension. (PMID: 15797661) Sano M … Kokubun S (American journal of hypertension 2005) 3 22 44 58
  4. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PMID: 8626685) Aiyar N … Li Y (The Journal of biological chemistry 1996) 2 3 4 58
  5. A human orphan calcitonin receptor-like structure. (PMID: 7818539) Flühmann B … Born W (Biochemical and biophysical research communications 1995) 2 3 4 58

Products for CALCRL Gene

Sources for CALCRL Gene

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