Aliases for CALCOCO2 Gene
External Ids for CALCOCO2 Gene
Previous GeneCards Identifiers for CALCOCO2 Gene
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for CALCOCO2 Gene
CALCOCO2 (Calcium Binding And Coiled-Coil Domain 2) is a Protein Coding gene. Diseases associated with CALCOCO2 include Influenza and Inflammatory Bowel Disease 19. Among its related pathways are Shigellosis and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TAX1BP1.
UniProtKB/Swiss-Prot Summary for CALCOCO2 Gene
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).