Aliases for CALCB Gene

Aliases for CALCB Gene

  • Calcitonin Related Polypeptide Beta 2 3 5
  • CGRP-II 2 3 4
  • Calcitonin Gene-Related Peptide II 3 4
  • Calcitonin Gene-Related Peptide 2 3 4
  • Beta-Type CGRP 3 4
  • Calcitonin 2 2 3
  • Beta-CGRP 3 4
  • CALC2 3 4
  • FLJ30166 2
  • CGRP2 3
  • CALCB 5

External Ids for CALCB Gene

Previous HGNC Symbols for CALCB Gene

  • CALC2

Previous GeneCards Identifiers for CALCB Gene

  • GC11P016107
  • GC11M015674
  • GC11P015135
  • GC11P015059
  • GC11P015051
  • GC11P014883
  • GC11P014926
  • GC11P014778

Summaries for CALCB Gene

GeneCards Summary for CALCB Gene

CALCB (Calcitonin Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include Thyroid Carcinoma, Familial Medullary and Migraine With Or Without Aura 1. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.

UniProtKB/Swiss-Prot Summary for CALCB Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Tocris Summary for CALCB Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Additional gene information for CALCB Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALCB Gene

Genomics for CALCB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CALCB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J015075 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.1 +169.4 169404 2.4 CTCF PRDM10 ZNF629 KDM1A ZNF692 ZNF143 ZIC2 PATZ1 REST RAD21 CALCB COPB1 CYP2R1 CALCA INSC lnc-INSC-4 piR-36668-002
GH11J014904 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 605.6 +0.5 455 1.9 SP1 CTCF REST EED DPF2 RUNX3 BCLAF1 TCF12 SMC3 YY1 CALCB CALCP CALCA
GH11J014902 Enhancer 0.4 Ensembl 605.6 -2.0 -1996 0.8 JUND ZNF316 FOSL1 IKZF1 CALCB CYP2R1
GH11J014894 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5.2 -8.1 -8096 5.8 LEF1 JUND PKNOX1 ZNF24 REST BRD9 DPF2 HDAC1 SOX6 FOXJ2 COPB1 OR7E41P CALCB CYP2R1 lnc-CALCB-1 PDE3B
GH11J014882 Enhancer 0.4 Ensembl 12 -22.6 -22596 0.4 CEBPG SOX6 IKZF1 MN309174-074 piR-41525-088 CALCB CALCP lnc-CALCA-2 CYP2R1 piR-41525-087 PDE3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALCB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALCB

Top Transcription factor binding sites by QIAGEN in the CALCB gene promoter:
  • AP-4
  • AREB6
  • Bach1
  • GATA-1
  • GATA-2
  • GATA-3
  • Hlf
  • IRF-1
  • RORalpha1
  • STAT1

Genomic Locations for CALCB Gene

Genomic Locations for CALCB Gene
chr11:14,904,997-15,082,342
(GRCh38/hg38)
Size:
177,346 bases
Orientation:
Plus strand
chr11:14,926,543-15,103,888
(GRCh37/hg19)
Size:
177,346 bases
Orientation:
Plus strand

Genomic View for CALCB Gene

Genes around CALCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCB Gene

Proteins for CALCB Gene

  • Protein details for CALCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10092-CALCB_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 2
    Protein Accession:
    P10092
    Secondary Accessions:
    • A8K573
    • D3DQX4
    • Q569I0
    • Q9UCN9

    Protein attributes for CALCB Gene

    Size:
    127 amino acids
    Molecular mass:
    13706 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALCB Gene

Post-translational modifications for CALCB Gene

  • Glycosylation at Ser34, Ser35, Thr40, Ser106, Thr111, and Ser115
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALCB Gene

Domains & Families for CALCB Gene

Gene Families for CALCB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CALCB Gene

InterPro:
Blocks:
  • Islet amyloid protein (amylin) signature
  • Beta-type calcitonin signature
ProtoNet:

Suggested Antigen Peptide Sequences for CALCB Gene

GenScript: Design optimal peptide antigens:
  • Calcitonin gene-related peptide II (CALCB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10092

UniProtKB/Swiss-Prot:

CALCB_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCB: view

Function for CALCB Gene

Molecular function for CALCB Gene

UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
GENATLAS Biochemistry:
calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator and hypotensor

Phenotypes From GWAS Catalog for CALCB Gene

Gene Ontology (GO) - Molecular Function for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity TAS 2985435
GO:0031716 calcitonin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CALCB: view
genes like me logo Genes that share phenotypes with CALCB: view

Animal Models for CALCB Gene

MGI Knock Outs for CALCB:

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCB

CRISPR Products

miRNA for CALCB Gene

miRTarBase miRNAs that target CALCB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALCB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCB Gene

Localization for CALCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCB gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CALCB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALCB Gene

Pathways & Interactions for CALCB Gene

genes like me logo Genes that share pathways with CALCB: view

Gene Ontology (GO) - Biological Process for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 2985435
GO:0007165 signal transduction TAS 2985435
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0051480 regulation of cytosolic calcium ion concentration IBA 21873635
genes like me logo Genes that share ontologies with CALCB: view

No data available for SIGNOR curated interactions for CALCB Gene

Drugs & Compounds for CALCB Gene

(7) Drugs for CALCB Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Eptinezumab Approved, Investigational Pharma Target, antibody 0
Fremanezumab Approved, Investigational Pharma Target, antibody 0
Galcanezumab Approved, Investigational Pharma Target, antibody 0
Telcagepant Investigational Pharma Target CGRP receptor antagonist 0
CGRP (rat) Pharma Potent vasodilator 0

(2) Additional Compounds for CALCB Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1

(5) Tocris Compounds for CALCB Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with CALCB: view

Transcripts for CALCB Gene

mRNA/cDNA for CALCB Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALCB

Alternative Splicing Database (ASD) splice patterns (SP) for CALCB Gene

No ASD Table

Relevant External Links for CALCB Gene

GeneLoc Exon Structure for
CALCB

Expression for CALCB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CALCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCB Gene

This gene is overexpressed in Brain - Hypothalamus (x24.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALCB

SOURCE GeneReport for Unigene cluster for CALCB Gene:

Hs.534305

Evidence on tissue expression from TISSUES for CALCB Gene

  • Nervous system(4.4)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with CALCB: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCB Gene

Orthologs for CALCB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CALCB 30 31
  • 99.48 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Calca 30 17
  • 84.39 (n)
Calcb 31
  • 71 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Calca 30
  • 83.6 (n)
Dog
(Canis familiaris)
Mammalia CALCB 30
  • 76.64 (n)
CALCA 31
  • 48 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia CALCB 30
  • 76.23 (n)
CRSP1 31
  • 35 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 32 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CALCA 31
  • 35 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 33 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100487527 30
  • 71.72 (n)
Zebrafish
(Danio rerio)
Actinopterygii calca 31
  • 36 (a)
OneToMany
Species where no ortholog for CALCB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CALCB Gene

ENSEMBL:
Gene Tree for CALCB (if available)
TreeFam:
Gene Tree for CALCB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CALCB: view image

Paralogs for CALCB Gene

Paralogs for CALCB Gene

(2) SIMAP similar genes for CALCB Gene using alignment to 2 proteins:

  • CALCB_HUMAN
  • E7ESF5_HUMAN
genes like me logo Genes that share paralogs with CALCB: view

Variants for CALCB Gene

Additional dbSNP identifiers (rs#s) for CALCB Gene

Structural Variations from Database of Genomic Variants (DGV) for CALCB Gene

Variant ID Type Subtype PubMed ID
esv2762897 CNV gain 21179565
esv3891932 CNV gain 25118596

Variation tolerance for CALCB Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALCB Gene

Human Gene Mutation Database (HGMD)
CALCB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALCB Gene

Disorders for CALCB Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALCB Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
thyroid carcinoma, familial medullary
  • mtc
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search CALCB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CALCB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CALCB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCB Gene

Publications for CALCB Gene

  1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 41
  2. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PMID: 15761041) Linscheid P … Müller B (Endocrinology 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PMID: 8468047) Hoovers JM … Mannens M (Genomics 1993) 3 23

Products for CALCB Gene

Sources for CALCB Gene