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CALCB (Calcitonin Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include Thyroid Carcinoma, Familial Medullary and Migraine With Or Without Aura 1. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J015075 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 600.1 | +169.4 | 169404 | 2.4 | CTCF PRDM10 ZNF629 KDM1A ZNF692 ZNF143 ZIC2 PATZ1 REST RAD21 | CALCB COPB1 CYP2R1 CALCA INSC lnc-INSC-4 piR-36668-002 | |
GH11J014904 | Promoter/Enhancer | 1.4 | Ensembl ENCODE CraniofacialAtlas | 605.6 | +0.5 | 455 | 1.9 | SP1 CTCF REST EED DPF2 RUNX3 BCLAF1 TCF12 SMC3 YY1 | CALCB CALCP CALCA | |
GH11J014902 | Enhancer | 0.4 | Ensembl | 605.6 | -2.0 | -1996 | 0.8 | JUND ZNF316 FOSL1 IKZF1 | CALCB CYP2R1 | |
GH11J014894 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 5.2 | -8.1 | -8096 | 5.8 | LEF1 JUND PKNOX1 ZNF24 REST BRD9 DPF2 HDAC1 SOX6 FOXJ2 | COPB1 OR7E41P CALCB CYP2R1 lnc-CALCB-1 PDE3B | |
GH11J014882 | Enhancer | 0.4 | Ensembl | 12 | -22.6 | -22596 | 0.4 | CEBPG SOX6 IKZF1 | MN309174-074 piR-41525-088 CALCB CALCP lnc-CALCA-2 CYP2R1 piR-41525-087 PDE3B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
GO:0005184 | neuropeptide hormone activity | TAS | 2985435 |
GO:0031716 | calcitonin receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005623 | cell | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Peptide ligand-binding receptors | ||
3 | Presynaptic function of Kainate receptors | ||
4 | Oxytocin signaling pathway | ||
5 | G alpha (s) signalling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006874 | cellular calcium ion homeostasis | TAS | 2985435 |
GO:0007165 | signal transduction | TAS | 2985435 |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0051480 | regulation of cytosolic calcium ion concentration | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Eptinezumab | Approved, Investigational | Pharma | Target, antibody | 0 | ||
Fremanezumab | Approved, Investigational | Pharma | Target, antibody | 0 | ||
Galcanezumab | Approved, Investigational | Pharma | Target, antibody | 0 | ||
Telcagepant | Investigational | Pharma | Target | CGRP receptor antagonist | 0 | |
CGRP (rat) | Pharma | Potent vasodilator | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
alpha-CGRP (human) |
|
90954-53-3 |
|
|
||
Calcitonin (salmon) |
|
47931-85-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
alpha-CGRP (human) | CGRP receptor agonist | 90954-53-3 |
Calcitonin (salmon) | Affects bone formation and resorption | 47931-85-1 |
CGRP (rat) | Potent vasodilator | 83651-90-5 |
PHM 27 (human) | Potent calcitonin receptor agonist; endogenous analog of human VIP | 118025-43-7 |
SUN-B 8155 | Non-peptide calcitonin (CT) receptor agonist | 345893-91-6 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CALCB 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Calca 30 17 |
|
||
Calcb 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Calca 30 |
|
||
Dog (Canis familiaris) |
Mammalia | CALCB 30 |
|
||
CALCA 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | CALCB 30 |
|
||
CRSP1 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | CALCA 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487527 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | calca 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762897 | CNV | gain | 21179565 |
esv3891932 | CNV | gain | 25118596 |
Disorder | Aliases | PubMed IDs |
---|---|---|
thyroid carcinoma, familial medullary |
|
|
migraine with or without aura 1 |
|
|