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CALCB Gene(Protein Coding)

Calcitonin Related Polypeptide Beta

GCID:
GC11P014926
GIFtS:
46
Genes Participants
UDN Logo

Aliases for CALCB Gene

Aliases for CALCB Gene

  • Calcitonin Related Polypeptide Beta 2 3 5
  • Calcitonin Gene-Related Peptide II 3 4
  • Beta-Type CGRP 3 4
  • Calcitonin 2 2 3
  • Beta-CGRP 3 4
  • CGRP-II 3 4
  • CALC2 3 4
  • Calcitonin Gene-Related Peptide 2 3
  • CGRP2 3

External Ids for CALCB Gene

Previous HGNC Symbols for CALCB Gene

  • CALC2

Previous GeneCards Identifiers for CALCB Gene

  • GC11P016107
  • GC11M015674
  • GC11P015135
  • GC11P015059
  • GC11P015051
  • GC11P014883
  • GC11P014778

Summaries for CALCB Gene

GeneCards Summary for CALCB Gene

CALCB (Calcitonin Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include Thyroid Carcinoma, Familial Medullary. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.

UniProtKB/Swiss-Prot for CALCB Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Tocris Summary for CALCB Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Additional gene information for CALCB Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCB Gene

Genomics for CALCB Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CALCB Gene

Promoters and enhancers for CALCB Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I014904 Promoter/Enhancer 1.2 Ensembl ENCODE 555.8 +0.4 376 1.7 CTCF MAX BACH1 EBF1 IRF4 RAD21 YY1 FOXM1 POLR2A HNF4G CALCB CALCP GC11M014875
GH11I015075 Promoter 1 EPDnew 550.1 +168.6 168577 0.1 ZBTB21 ZNF449 ZNF140 MZF1 CEBPG ZNF335 GLIS2 POLR2A ZNF391 ZBTB20 CALCB CALCA INSC GC11P015078 GC11P015027
GH11I014635 Enhancer 0.5 Ensembl ENCODE 10.2 -268.8 -268752 1.1 ZNF26 CALCB CALCP CYP2R1 PSMA1 PIR39085
GH11I014638 Enhancer 0.4 dbSUPER 10.1 -265.3 -265254 2.3 POLR2A ZNF24 RAD21 CALCB CALCP COPB1 PSMA1 PIR39085
GH11I014783 Enhancer 0.2 ENCODE 12 -120.7 -120710 0.9 CALCB CALCP SPON1 GC11P014892 MORF4L1P3 PDE3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALCB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALCB gene promoter:

Genomic Locations for CALCB Gene

Genomic Locations for CALCB Gene
chr11:14,904,997-15,082,342
(GRCh38/hg38)
Size:
177,346 bases
Orientation:
Plus strand
chr11:14,926,543-15,103,888
(GRCh37/hg19)

Genomic View for CALCB Gene

Genes around CALCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CALCB Gene

Proteins for CALCB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CALCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10092-CALCB_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 2
    Protein Accession:
    P10092
    Secondary Accessions:
    • A8K573
    • D3DQX4
    • Q569I0
    • Q9UCN9

    Protein attributes for CALCB Gene

    Size:
    127 amino acids
    Molecular mass:
    13706 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALCB Gene

Post-translational modifications for CALCB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALCB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALCB Gene

Domains & Families for CALCB Gene

Gene Families for CALCB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CALCB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CALCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10092

UniProtKB/Swiss-Prot:

CALCB_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCB: view

Function for CALCB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CALCB Gene

GENATLAS Biochemistry:
calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator and hypotensor
UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Phenotypes From GWAS Catalog for CALCB Gene

Gene Ontology (GO) - Molecular Function for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity TAS 2985435
genes like me logo Genes that share ontologies with CALCB: view
genes like me logo Genes that share phenotypes with CALCB: view

Animal Models for CALCB Gene

MGI Knock Outs for CALCB:

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCB

miRNA for CALCB Gene

miRTarBase miRNAs that target CALCB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCB Gene

Localization for CALCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCB gene
Compartment Confidence
extracellular 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CALCB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALCB Gene

Pathways & Interactions for CALCB Gene

genes like me logo Genes that share pathways with CALCB: view

Gene Ontology (GO) - Biological Process for CALCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 2985435
GO:0007165 signal transduction TAS 2985435
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with CALCB: view

No data available for SIGNOR curated interactions for CALCB Gene

Drugs & Compounds for CALCB Gene

Products:

  1. Drug

(4) Drugs for CALCB Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Telcagepant Investigational Pharma Target CGRP receptor antagonist 0
CGRP (rat) Pharma Potent vasodilator 0

(2) Additional Compounds for CALCB Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3

(5) Tocris Compounds for CALCB Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with CALCB: view

Transcripts for CALCB Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CALCB Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALCB Gene

Calcitonin-related polypeptide beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCB Gene

No ASD Table

Relevant External Links for CALCB Gene

GeneLoc Exon Structure for
CALCB
ECgene alternative splicing isoforms for
CALCB

Expression for CALCB Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALCB Gene

mRNA expression in normal human tissues for CALCB Gene
mRNA expression by BioGPS for CALCB GenemRNA expression by GTEx for CALCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCB Gene

This gene is overexpressed in Brain - Hypothalamus (x24.1).

NURSA nuclear receptor signaling pathways regulating expression of CALCB Gene:

CALCB

SOURCE GeneReport for Unigene cluster for CALCB Gene:

Hs.534305

Evidence on tissue expression from TISSUES for CALCB Gene

  • Nervous system(4.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CALCB: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCB Gene

Orthologs for CALCB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CALCB 33 34
  • 99.48 (n)
mouse
(Mus musculus)
 Mammalia Calca 33 16
  • 84.39 (n)
Calcb 34
  • 71 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Calca 33
  • 83.6 (n)
dog
(Canis familiaris)
 Mammalia CALCB 33
  • 76.64 (n)
CALCA 34
  • 48 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia CALCB 33
  • 76.23 (n)
CRSP1 34
  • 35 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 62 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 32 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CALCA 34
  • 35 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 33 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487527 33
  • 71.72 (n)
zebrafish
(Danio rerio)
 Actinopterygii calca 34
  • 36 (a)
 OneToMany
Species where no ortholog for CALCB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALCB Gene

ENSEMBL:
Gene Tree for CALCB (if available)
TreeFam:
Gene Tree for CALCB (if available)

Paralogs for CALCB Gene

Paralogs for CALCB Gene

(2) SIMAP similar genes for CALCB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALCB: view

Variants for CALCB Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CALCB Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000390208 -- 15,071,645(+) C/T upstream_transcript_variant
rs1000828768 -- 15,075,828(+) G/T intron_variant
rs1000932244 -- 15,076,110(+) G/C intron_variant
rs1001162151 -- 15,074,384(+) A/G intron_variant
rs1001276587 -- 15,074,692(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CALCB Gene

Variant ID Type Subtype PubMed ID
esv2762897 CNV gain 21179565
esv3891932 CNV gain 25118596

Variation tolerance for CALCB Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALCB Gene

Human Gene Mutation Database (HGMD)
CALCB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCB Gene

Disorders for CALCB Gene

MalaCards: The human disease database

(1) MalaCards diseases for CALCB Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
thyroid carcinoma, familial medullary
  • mtc
- elite association - COSMIC cancer census association via MalaCards
Search CALCB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CALCB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CALCB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCB Gene

Publications for CALCB Gene

  1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  2. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PMID: 15761041) Linscheid P … Müller B (Endocrinology 2005) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PMID: 8468047) Hoovers JM … Mannens M (Genomics 1993) 3 22 58

Products for CALCB Gene

Sources for CALCB Gene

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