Aliases for CALCB Gene
Aliases for CALCB Gene
External Ids for CALCB Gene
- HGNC: 1438
- Entrez Gene: 797
- Ensembl: ENSG00000175868
- OMIM: 114160
- UniProtKB: P10092
Previous HGNC Symbols for CALCB Gene
- CALC2
Previous GeneCards Identifiers for CALCB Gene
- GC11P016107
- GC11M015674
- GC11P015135
- GC11P015059
- GC11P015051
- GC11P014883
- GC11P014778
Summaries for CALCB Gene
GeneCards Summary for CALCB Gene
CALCB (Calcitonin Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include Thyroid Carcinoma, Familial Medullary and Thyroid Cancer, Nonmedullary, 2. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.
UniProtKB/Swiss-Prot for CALCB Gene
-
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
-
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.
No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCB Gene
Genomics for CALCB Gene
GeneHancer (GH) Regulatory Elements for CALCB Gene
Promoters and enhancers for CALCB Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J014904 | Promoter/Enhancer | 1.2 | Ensembl ENCODE | 655.7 | +0.4 | 376 | 1.7 | CTCF MAX BACH1 EBF1 IRF4 RAD21 YY1 ETS1 FOXM1 POLR2A | CALCB CALCP GC11M014875 | |
| GH11J015075 | Promoter | 1 | EPDnew | 650.1 | +168.6 | 168577 | 0.1 | ZBTB21 ZNF140 MZF1 CEBPG ZNF335 GLIS2 POLR2A ZBTB20 L3MBTL2 ZBTB11 | CALCB CALCA INSC GC11P015078 GC11P015027 | |
| GH11J014635 | Enhancer | 0.5 | Ensembl ENCODE | 10.2 | -268.8 | -268752 | 1.1 | ZNF26 | CALCB CALCP CYP2R1 PSMA1 PIR39085 | |
| GH11J014638 | Enhancer | 0.5 | dbSUPER | 10.1 | -265.3 | -265254 | 2.3 | RXRA POLR2A ZNF24 RAD21 | CALCB CALCP COPB1 PSMA1 PIR39085 | |
| GH11J014783 | Enhancer | 0.2 | ENCODE | 12 | -120.7 | -120710 | 0.9 | CALCP CALCB SPON1 GC11P014892 MORF4L1P3 PDE3B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CALCB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CALCB gene promoter:
-
- Hlf
- AREB6
- GATA-3
- GATA-2
- GATA-1
- STAT1
- RORalpha1
- IRF-1
- Bach1
- AP-4
Regulatory Element Products
Genomic Locations for CALCB Gene
Genomic Locations for CALCB Gene
- chr11:14,904,997-15,082,342
- (GRCh38/hg38)
- Size:
- 177,346 bases
- Orientation:
- Plus strand
- chr11:14,926,543-15,103,888
- (GRCh37/hg19)
- Size:
- 177,346 bases
- Orientation:
- Plus strand
Genomic View for CALCB Gene
Genes around CALCB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.2 by Entrez Gene
- 11p15.2 by HGNC
- 11p15.2 by Ensembl
CALCB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CALCB Gene
Proteins for CALCB Gene
-
Protein details for CALCB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10092-CALCB_HUMAN
- Recommended name:
- Calcitonin gene-related peptide 2
- Protein Accession:
- P10092
- A8K573
- D3DQX4
- Q569I0
- Q9UCN9
Protein attributes for CALCB Gene
- Size:
- 127 amino acids
- Molecular mass:
- 13706 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CALCB Gene
Other Protein References for CALCB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CALCB
- Invitrogen Antibodies for CALCB (AFLGC-CALCB)
- GeneTex CALCB Antibody for CALCB
-
Boster Bio Antibodies for CALCB
-
Santa Cruz Biotechnology (SCBT) Antibodies for CALCB
Protein Products
-
OriGene Purified Proteins for CALCB
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- Search GeneTex for Proteins for CALCB
-
ProSci Proteins for CALCB
Assay Products
No data available for DME Specific Peptides for CALCB Gene
Domains & Families for CALCB Gene
Gene Families for CALCB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CALCB Gene
Suggested Antigen Peptide Sequences for CALCB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10092- Family:
-
- Belongs to the calcitonin family.
Function for CALCB Gene
Molecular function for CALCB Gene
- UniProtKB/Swiss-Prot Function:
- CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
- GENATLAS Biochemistry:
- calcitonin-related peptide,beta,3.8kDa,expressed in parts of nervous and endocrine system,potent vasodilatator and hypotensor
Phenotypes From GWAS Catalog for CALCB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005184 | neuropeptide hormone activity | TAS | 2985435 |
Phenotypes for CALCB Gene
- MGI mutant phenotypes for CALCB:
-
inferred from 7 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- mortality/aging
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- GenomeRNAi human phenotypes for CALCB:
-
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability
- no effect
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Increased vaccinia virus (VACV) infection
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased NF-kappaB reporter expression
Animal Models for CALCB Gene
Animal Model Products
-
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-
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-
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- Overview of 97 available CALCB gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for CALCB Gene
- miRTarBase miRNAs that target CALCB
miRNA Products
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- Overview of 97 available CALCB gene related products
Clone Products
- Sino Biological Human cDNA Clone for CALCB
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CALCB
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCB Gene
Localization for CALCB Gene
Subcellular locations from UniProtKB/Swiss-Prot for CALCB Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005623 | cell | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALCB Gene
Pathways & Interactions for CALCB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Presynaptic function of Kainate receptors | ||
| 3 | G alpha (s) signalling events | ||
| 4 | Peptide ligand-binding receptors | ||
Pathways by source for CALCB Gene
7 Reactome pathways for CALCB Gene
Interacting Proteins for CALCB Gene
GPS-Prot Interaction Network for CALCB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006874 | cellular calcium ion homeostasis | TAS | 2985435 |
| GO:0007165 | signal transduction | TAS | 2985435 |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0010469 | regulation of signaling receptor activity | IEA | -- |
No data available for SIGNOR curated interactions for CALCB Gene
Drugs & Compounds for CALCB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Eptinezumab | Investigational | Pharma | Target, antibody | 0 | ||
| Fremanezumab | Investigational | Pharma | Target, antibody | 0 | ||
| Galcanezumab | Investigational | Pharma | Target, antibody | 0 | ||
| Telcagepant | Investigational | Pharma | Target | CGRP receptor antagonist | 0 | |
| CGRP (rat) | Pharma | Potent vasodilator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| alpha-CGRP (human) |
|
90954-53-3 |
|
|
||
| Calcitonin (salmon) |
|
47931-85-1 |
|
|
(5) Tocris Compounds for CALCB Gene
| Compound | Action | Cas Number |
|---|---|---|
| alpha-CGRP (human) | CGRP receptor agonist | 90954-53-3 |
| Calcitonin (salmon) | Affects bone formation and resorption | 47931-85-1 |
| CGRP (rat) | Potent vasodilator | 83651-90-5 |
| PHM 27 (human) | Potent calcitonin receptor agonist; endogenous analog of human VIP | 118025-43-7 |
| SUN-B 8155 | Non-peptide calcitonin (CT) receptor agonist | 345893-91-6 |
Drug Products
Transcripts for CALCB Gene
mRNA/cDNA for CALCB Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (13) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000523376 2258 bps (uc057zjf.1)
- ENST00000324229 1070 bps (uc001mlx.2)
- ENST00000533448 2097 bps (uc009ygr.2)
Unigene Clusters for CALCB Gene
CRISPR Products
-
OriGene CRISPR knockouts for CALCB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CALCB
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- Applied Biological Materials CRISPR for CALCB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CALCB
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CALCB
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- Overview of 97 available CALCB gene related products
Clone Products
- Sino Biological Human cDNA Clone for CALCB
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- Applied Biological Materials Clones for CALCB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CALCB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Hypothalamus
- Thalamus
- Cerebellum
- Amygdala
-
Lung (Respiratory System)
- Neuroendocrine Cells Trachea
- Neuroendocrine Cells Stem Bronchi
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Epithelial Cells
- Neuroendocrine Cells Stem Bronchi
-
Neurons
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CALCB Gene
This gene is overexpressed in Brain - Hypothalamus (x24.1).
NURSA nuclear receptor signaling pathways regulating expression of CALCB Gene:
CALCBSOURCE GeneReport for Unigene cluster for CALCB Gene:
Hs.534305Evidence on tissue expression from TISSUES for CALCB Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for CALCB
-
OriGene qPCR primer pairs and template standards for CALCB
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCB Gene
Orthologs for CALCB Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CALCB 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Calca 16 33 |
|
||
| Calcb 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Calca 33 |
|
||
| dog (Canis familiaris) |
Mammalia | CALCB 33 |
|
||
| CALCA 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | CALCB 33 |
|
||
| CRSP1 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CALCA 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100487527 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | calca 34 |
|
OneToMany |
- Species where no ortholog for CALCB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CALCB Gene
- ENSEMBL:
- Gene Tree for CALCB (if available)
- TreeFam:
- Gene Tree for CALCB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CALCB: view image
Paralogs for CALCB Gene
Variants for CALCB Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000390208 | -- | 15,071,645(+) | C/T | upstream_transcript_variant | |
| rs1000828768 | -- | 15,075,828(+) | G/T | intron_variant | |
| rs1000932244 | -- | 15,076,110(+) | G/C | intron_variant | |
| rs1001162151 | -- | 15,074,384(+) | A/G | intron_variant | |
| rs1001276587 | -- | 15,074,692(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2762897 | CNV | gain | 21179565 |
| esv3891932 | CNV | gain | 25118596 |
Residual Variation Intolerance Score:
34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.27;
6.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CALCB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCB Gene
Disorders for CALCB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thyroid carcinoma, familial medullary |
|
|
| thyroid cancer, nonmedullary, 2 |
|
|
Search CALCB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CALCB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CALCB Gene
Publications for CALCB Gene
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
- Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. (PMID: 15761041) Linscheid P … Müller B (Endocrinology 2005) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. (PMID: 8468047) Hoovers JM … Mannens M (Genomics 1993) 3 22 58
Products for CALCB Gene
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Sources for CALCB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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