This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobi... See more...

Aliases for CALCA Gene

Aliases for CALCA Gene

  • Calcitonin Related Polypeptide Alpha 2 3 5
  • Calcitonin 2 3 4
  • Calcitonin Gene-Related Peptide 1 3 4
  • Calcitonin Gene-Related Peptide I 3 4
  • Alpha-Type CGRP 3 4
  • Calcitonin 1 2 3
  • CGRP-Alpha 2 3
  • CGRP-I 3 4
  • CALC1 3 4
  • CGRP 2 3
  • Calcitonin/Calcitonin-Related Polypeptide, Alpha 3
  • Katacalcin 3
  • CGRP1 3
  • CALCA 5
  • PCT 3
  • CT 3
  • KC 3

External Ids for CALCA Gene

Previous HGNC Symbols for CALCA Gene

  • CALC1

Previous GeneCards Identifiers for CALCA Gene

  • GC11M016170
  • GC11M015736
  • GC11M015027
  • GC11M014952
  • GC11M014671

Summaries for CALCA Gene

Entrez Gene Summary for CALCA Gene

  • This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

GeneCards Summary for CALCA Gene

CALCA (Calcitonin Related Polypeptide Alpha) is a Protein Coding gene. Diseases associated with CALCA include Reflex Sympathetic Dystrophy and Spinal Stenosis. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CALCB.

UniProtKB/Swiss-Prot Summary for CALCA Gene

  • CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
  • Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
  • Katacalcin is a potent plasma calcium-lowering peptide.

Tocris Summary for CALCA Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCA Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CALCA Gene

Genomics for CALCA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CALCA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J014972 Promoter/Enhancer 0.8 EPDnew Ensembl 600.7 +0.1 60 0.6 EZH2 ATF4 CEBPG TBP CALCA lnc-CYP2R1-2 CALCB
GH11J015075 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.1 -102.0 -102040 2.4 CTCF PRDM10 ZNF629 KDM1A ZNF692 ZNF143 ZIC2 PATZ1 REST RAD21 CALCB COPB1 CYP2R1 CALCA INSC lnc-INSC-4 piR-36668-002
GH11J015041 Enhancer 0.2 Ensembl 10.4 -69.4 -69440 1.6 CALCA piR-57133-068 piR-48344-003 INSC CALCB
GH11J014976 Enhancer 0.6 ENCODE 0.7 -2.6 -2569 0.2 CTCF PKNOX1 EZH2 ZNF335 PRDM4 RAD21 TRIM28 ZNF143 MEIS2 XRCC5 CALCA OR7E41P lnc-CALCA-1 CALCB INSC
GH11J014974 Enhancer 0.5 ENCODE 0.7 -2.3 -2329 0.1 CTCF PKNOX1 EZH2 XRCC5 POLR2A RAD21 TRIM22 CALCA OR7E41P lnc-CALCA-1 CALCB INSC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CALCA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CALCA

Top Transcription factor binding sites by QIAGEN in the CALCA gene promoter:
  • CREB
  • deltaCREB

Genomic Locations for CALCA Gene

Genomic Locations for CALCA Gene
chr11:14,966,668-14,972,361
(GRCh38/hg38)
Size:
5,694 bases
Orientation:
Minus strand
chr11:14,988,214-14,993,900
(GRCh37/hg19)
Size:
5,687 bases
Orientation:
Minus strand

Genomic View for CALCA Gene

Genes around CALCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCA Gene

Proteins for CALCA Gene

  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06881-CALCA_HUMAN
    Recommended name:
    Calcitonin gene-related peptide 1
    Protein Accession:
    P06881
    Secondary Accessions:
    • Q93048
    • Q9UCP0

    Protein attributes for CALCA Gene

    Size:
    128 amino acids
    Molecular mass:
    13899 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:
  • Protein details for CALCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01258-CALC_HUMAN
    Recommended name:
    Calcitonin
    Protein Accession:
    P01258
    Secondary Accessions:
    • B7ZL39
    • Q13935
    • Q13937
    • Q52LX7

    Protein attributes for CALCA Gene

    Size:
    141 amino acids
    Molecular mass:
    15467 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for CALCA Gene

    Alternative splice isoforms for CALCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALCA Gene

Post-translational modifications for CALCA Gene

  • Glycosylation at Thr105 and Thr109
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CALCA Gene

Domains & Families for CALCA Gene

Gene Families for CALCA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CALCA Gene

InterPro:
Blocks:
  • Islet amyloid protein (amylin) signature
  • Beta-type calcitonin signature
  • Alpha-type calcitonin signature
ProtoNet:

Suggested Antigen Peptide Sequences for CALCA Gene

GenScript: Design optimal peptide antigens:
  • Calcitonin gene-related peptide I (CALCA_HUMAN)
  • Calcitonin (CALC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06881

UniProtKB/Swiss-Prot:

CALC_HUMAN :
  • Belongs to the calcitonin family.
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with CALCA: view

Function for CALCA Gene

Molecular function for CALCA Gene

UniProtKB/Swiss-Prot Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
UniProtKB/Swiss-Prot Function:
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
UniProtKB/Swiss-Prot Function:
Katacalcin is a potent plasma calcium-lowering peptide.
GENATLAS Biochemistry:
calcitonin,3.4kDa and calcitonin related peptide,alpha,3.8kDa,formed by alternative splicing of the same gene,expressed in thyroid C cells,involved in calcium homeostasis,mediating the effects of Indian Hedgehog and PTH related peptide on chondrocyte differentiation,also expressed in parts of the nervous and endocrine system,potent vasodilatator and hypotensor

Phenotypes From GWAS Catalog for CALCA Gene

Gene Ontology (GO) - Molecular Function for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IDA --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 17689535
GO:0031716 calcitonin receptor binding IPI 8078488
GO:0042802 identical protein binding IPI 23395606
genes like me logo Genes that share ontologies with CALCA: view
genes like me logo Genes that share phenotypes with CALCA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CALCA

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALCA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALCA Gene

Localization for CALCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALCA gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 3
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18057382
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA --
genes like me logo Genes that share ontologies with CALCA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALCA Gene

Pathways & Interactions for CALCA Gene

genes like me logo Genes that share pathways with CALCA: view

Pathways by source for CALCA Gene

1 GeneGo (Thomson Reuters) pathway for CALCA Gene
  • Transcription_Role of VDR in regulation of genes involved in osteoporosis
1 Cell Signaling Technology pathway for CALCA Gene

Gene Ontology (GO) - Biological Process for CALCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001935 endothelial cell proliferation IDA --
GO:0001944 vasculature development IDA --
GO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0002031 G protein-coupled receptor internalization IDA --
GO:0002548 monocyte chemotaxis IDA 15248232
genes like me logo Genes that share ontologies with CALCA: view

No data available for SIGNOR curated interactions for CALCA Gene

Drugs & Compounds for CALCA Gene

(97) Drugs for CALCA Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Eptinezumab Approved, Investigational Pharma Target, antibody 0
Fremanezumab Approved, Investigational Pharma Target, antibody 0
Galcanezumab Approved, Investigational Pharma Target, antibody 0
botulinum toxin type a Approved, Investigational Pharma 0
cyclic amp Experimental Pharma 0

(45) Additional Compounds for CALCA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1

(5) Tocris Compounds for CALCA Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6

(6) ApexBio Compounds for CALCA Gene

Compound Action Cas Number
BMS-927711 CGRP receptor antagonist 1289023-67-1
CGRP (rat) 83651-90-5
CGRP 8-37 (rat) 129121-73-9
MK-0974 CGRP receptor antagonist 781649-09-0
MK-3207 CGRP receptor antagonist 957118-49-9
Olcegepant Non-peptide receptor of CGRP,first potent and selective 204697-65-4
genes like me logo Genes that share compounds with CALCA: view

Transcripts for CALCA Gene

mRNA/cDNA for CALCA Gene

5 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CALCA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for CALCA Gene

GeneLoc Exon Structure for
CALCA

Expression for CALCA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CALCA Gene

mRNA differential expression in normal tissues according to GTEx for CALCA Gene

This gene is overexpressed in Thyroid (x23.1) and Liver (x15.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CALCA

SOURCE GeneReport for Unigene cluster for CALCA Gene:

Hs.37058

Evidence on tissue expression from TISSUES for CALCA Gene

  • Thyroid gland(4.1)
  • Nervous system(3.8)
  • Blood(3.3)
  • Bone(3.3)
  • Kidney(3.1)
  • Muscle(3.1)
  • Intestine(2.8)
  • Heart(2.8)
  • Skin(2.7)
  • Urine(2.6)
  • Stomach(2.6)
  • Adrenal gland(2.6)
  • Lymph node(2.5)
  • Lung(2.5)
  • Liver(2.5)
  • Pancreas(2.5)
  • Bone marrow(2.3)
  • Spleen(2.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with CALCA: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALCA Gene

Orthologs for CALCA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALCA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CALCA 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CALCA 30
  • 75.15 (n)
CT 31
  • 61 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CRSP-3 30 31
  • 75.07 (n)
OneToMany
CRSP-2 31
  • 72 (a)
OneToMany
CRSP1 31
  • 43 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Calca 31
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 45 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 42 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CALCA 31
  • 48 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii calca 31
  • 45 (a)
OneToMany
Species where no ortholog for CALCA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CALCA Gene

ENSEMBL:
Gene Tree for CALCA (if available)
TreeFam:
Gene Tree for CALCA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CALCA: view image

Paralogs for CALCA Gene

Paralogs for CALCA Gene

(2) SIMAP similar genes for CALCA Gene using alignment to 2 proteins:

  • CALCA_HUMAN
  • CALC_HUMAN

Pseudogenes.org Pseudogenes for CALCA Gene

genes like me logo Genes that share paralogs with CALCA: view

Variants for CALCA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CALCA Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
17637 Benign: Calcitonin polymorphism 14,968,069(-) A/. INTRON_VARIANT
768429 Benign: not provided 14,968,847(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
785341 Benign: not provided 14,968,907(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
rs5239 -. - p.Asp57Asn
rs13306224 - p.Gln138Pro

Additional dbSNP identifiers (rs#s) for CALCA Gene

Structural Variations from Database of Genomic Variants (DGV) for CALCA Gene

Variant ID Type Subtype PubMed ID
esv3578250 CNV gain 25503493
nsv832071 CNV loss 17160897

Variation tolerance for CALCA Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALCA Gene

Human Gene Mutation Database (HGMD)
CALCA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCA Gene

Disorders for CALCA Gene

MalaCards: The human disease database

(199) MalaCards diseases for CALCA Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
reflex sympathetic dystrophy
  • complex regional pain syndrome
spinal stenosis
  • cervical spinal stenosis
giant cell reparative granuloma
  • central giant cell granuloma
complex regional pain syndrome
  • reflex sympathetic dystrophy
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search CALCA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CALCA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CALCA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCA Gene

Publications for CALCA Gene

  1. Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PMID: 1318039) Kitamura K … Eto T (Biochemical and biophysical research communications 1992) 3 4 23
  2. The complete sequence of human preprocalcitonin. (PMID: 6546550) Le Moullec JM … Moukhtar MS (FEBS letters 1984) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. (PMID: 20173430) Herlyn P … Gradl G (The Clinical journal of pain 2010) 3 41
  5. BDNF and CGRP interaction: implications in migraine susceptibility. (PMID: 20959432) Lemos C … Sousa A (Cephalalgia : an international journal of headache 2010) 3 41

Products for CALCA Gene

Sources for CALCA Gene