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Aliases for CAGE1 Gene

Aliases for CAGE1 Gene

  • Cancer Antigen 1 2 3 5
  • Cancer/Testis Antigen 3 2 3 4
  • Cancer/Testis Antigen 95 2 3
  • CTAG3 3 4
  • CT3 3 4
  • Cancer-Associated Gene 1 Protein 3
  • Cancer/Testis Antigen Gene 1 3
  • BA69L16.7 3
  • CAGE-1 4
  • CT95 3

External Ids for CAGE1 Gene

Previous HGNC Symbols for CAGE1 Gene

  • CTAG3

Previous GeneCards Identifiers for CAGE1 Gene

  • GC06M007312
  • GC06M007273

Summaries for CAGE1 Gene

GeneCards Summary for CAGE1 Gene

CAGE1 (Cancer Antigen 1) is a Protein Coding gene. Diseases associated with CAGE1 include Chronic Frontal Sinusitis and Rectal Neoplasm.

Additional gene information for CAGE1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAGE1 Gene

Genomics for CAGE1 Gene

GeneHancer (GH) Regulatory Elements for CAGE1 Gene

Promoters and enhancers for CAGE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J007388 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.1 -94 3.1 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 RIOK1 CAGE1 SSR1 DSP RREB1 ENSG00000225092 ENSG00000238221 GC06P007402
GH06J007339 Promoter/Enhancer 1.3 EPDnew ENCODE 661 +50.4 50443 0.2 ELF3 ARID4B ZNF48 ZSCAN9 RAD21 ZNF614 CBX5 ATF7 THAP11 NFKBIZ CAGE1 RPS3P4 ENSG00000238221 RIOK1 SSR1 ENSG00000219375
GH06J007311 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 +76.8 76771 3.3 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 SP3 NFYC ZNF610 SSR1 GC06M007189 RIOK1 CAGE1 ENSG00000238221 SNRNP48 GC06M007303
GH06J007134 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7 +247.6 247552 14.8 MLX FEZF1 DMAP1 IRF4 YY1 ZNF143 SP3 NFYC MEF2D GLIS1 RREB1 SSR1 RIOK1 CAGE1 ENSG00000225092
GH06J007112 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +276.7 276664 1.8 HDAC1 IRF2 FOXA2 SAP130 ARID4B KAT7 SIN3A ERF ZNF644 RAD21 CAGE1 RREB1 RIOK1 ENSG00000225092
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAGE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CAGE1 gene promoter:
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • AREB6
  • Pbx1a
  • HTF
  • Meis-1
  • Meis-1a
  • Meis-1b
  • TGIF

Genomic Locations for CAGE1 Gene

Genomic Locations for CAGE1 Gene
63,090 bases
Minus strand
63,090 bases
Minus strand

Genomic View for CAGE1 Gene

Genes around CAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAGE1 Gene

Proteins for CAGE1 Gene

  • Protein details for CAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cancer-associated gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • D6RCT9
    • Q5TAM0
    • Q86TM4
    • Q8N7R5

    Protein attributes for CAGE1 Gene

    777 amino acids
    Molecular mass:
    90250 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI16451.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CAGE1 Gene


neXtProt entry for CAGE1 Gene

Post-translational modifications for CAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAGE1 Gene

Domains & Families for CAGE1 Gene

Gene Families for CAGE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAGE1 Gene


Suggested Antigen Peptide Sequences for CAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAGE1: view

No data available for UniProtKB/Swiss-Prot for CAGE1 Gene

Function for CAGE1 Gene

Phenotypes From GWAS Catalog for CAGE1 Gene

Gene Ontology (GO) - Molecular Function for CAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CAGE1: view
genes like me logo Genes that share phenotypes with CAGE1: view

Animal Model Products

CRISPR Products

miRNA for CAGE1 Gene

miRTarBase miRNAs that target CAGE1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAGE1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAGE1 Gene

Localization for CAGE1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAGE1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CAGE1 Gene

Pathways & Interactions for CAGE1 Gene

SuperPathways for CAGE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAGE1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CAGE1 Gene

Drugs & Compounds for CAGE1 Gene

No Compound Related Data Available

Transcripts for CAGE1 Gene

mRNA/cDNA for CAGE1 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAGE1 Gene

Cancer antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAGE1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAGE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - - -

Relevant External Links for CAGE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAGE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAGE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAGE1 Gene

This gene is overexpressed in Testis (x49.4).

Protein differential expression in normal tissues from HIPED for CAGE1 Gene

This gene is overexpressed in Islet of Langerhans (43.6) and Urine (25.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAGE1 Gene

Protein tissue co-expression partners for CAGE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAGE1 Gene:


SOURCE GeneReport for Unigene cluster for CAGE1 Gene:


mRNA Expression by UniProt/SwissProt for CAGE1 Gene:

Tissue specificity: Testis-specific expression in normal tissues, but wide expression among cancer tissues and cell lines.

Evidence on tissue expression from TISSUES for CAGE1 Gene

  • Lymph node(2.6)
  • Intestine(2.4)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with CAGE1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAGE1 Gene

Orthologs for CAGE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAGE1 34 33
  • 99.44 (n)
(Bos Taurus)
Mammalia CAGE1 34 33
  • 80.26 (n)
(Canis familiaris)
Mammalia CAGE1 34 33
  • 77.2 (n)
(Mus musculus)
Mammalia Cage1 16 34 33
  • 73.15 (n)
(Rattus norvegicus)
Mammalia Cage1 33
  • 72.5 (n)
(Monodelphis domestica)
Mammalia CAGE1 34
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia CAGE1 34
  • 39 (a)
Species where no ortholog for CAGE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAGE1 Gene

Gene Tree for CAGE1 (if available)
Gene Tree for CAGE1 (if available)
Evolutionary constrained regions (ECRs) for CAGE1: view image

Paralogs for CAGE1 Gene

No data available for Paralogs for CAGE1 Gene

Variants for CAGE1 Gene

Sequence variations from dbSNP and Humsavar for CAGE1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000007537 -- 7,350,057(-) T/C intron_variant
rs1000106173 -- 7,328,452(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000115397 -- 7,357,170(-) C/T intron_variant
rs1000144530 -- 7,349,815(-) C/G intron_variant
rs1000159068 -- 7,330,343(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAGE1 Gene

Variant ID Type Subtype PubMed ID
esv3608006 CNV loss 21293372
esv3890787 CNV loss 25118596
nsv1073955 CNV deletion 25765185
nsv1114773 CNV deletion 24896259
nsv1133014 OTHER inversion 24896259
nsv1151332 OTHER inversion 26484159
nsv462623 CNV gain 19166990
nsv470797 CNV gain 18288195
nsv600890 CNV gain 21841781
nsv965678 CNV duplication 23825009
nsv981350 CNV duplication 23825009

Variation tolerance for CAGE1 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAGE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAGE1 Gene

Disorders for CAGE1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CAGE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic frontal sinusitis
rectal neoplasm
  • neoplasm of rectum
rectum adenocarcinoma
  • adenocarcinoma of rectum
prostate lymphoma
  • lymphoma of prostate
frontal sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search CAGE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CAGE1

genes like me logo Genes that share disorders with CAGE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAGE1 Gene

Publications for CAGE1 Gene

  1. Identification and characterization of a novel cancer/testis antigen gene CAGE-1. (PMID: 12531476) Park S … Jeoung DI (Biochimica et biophysica acta 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CAGE1 Gene

Sources for CAGE1 Gene

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