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Aliases for CADM4 Gene

Aliases for CADM4 Gene

  • Cell Adhesion Molecule 4 2 3 5
  • Immunoglobulin Superfamily Member 4C 3 4
  • Nectin-Like Protein 4 3 4
  • TSLC1-Like Protein 2 3 4
  • Nectin-Like 4 2 3
  • Necl-4 3 4
  • IGSF4C 3 4
  • NECL4 3 4
  • TSLL2 3 4
  • Immunoglobulin Superfamily, Member 4C 2
  • TSLC1-Like 2 3
  • SynCAM4 3

External Ids for CADM4 Gene

Previous HGNC Symbols for CADM4 Gene

  • IGSF4C

Previous GeneCards Identifiers for CADM4 Gene

  • GC19M048821
  • GC19M044126
  • GC19M040557

Summaries for CADM4 Gene

GeneCards Summary for CADM4 Gene

CADM4 (Cell Adhesion Molecule 4) is a Protein Coding gene. Diseases associated with CADM4 include Renal Clear Cell Carcinoma and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. An important paralog of this gene is CADM1.

UniProtKB/Swiss-Prot for CADM4 Gene

  • Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.

Additional gene information for CADM4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM4 Gene

Genomics for CADM4 Gene

GeneHancer (GH) Regulatory Elements for CADM4 Gene

Promoters and enhancers for CADM4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043639 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.0 38 0.8 ARID4B FEZF1 ZNF2 ZBTB7B E2F8 ZNF416 ZNF207 ZNF143 SP3 SP5 CADM4 ZNF45 ZNF225 ZNF227 ZNF180 ZNF235 ZNF283 ZNF226 ZNF221 ZNF223
GH19I043594 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +43.4 43444 4.5 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 ZNF576 IRGQ SRRM5 ZNF45 ZNF180 ZNF112 ZNF283 ZNF224 ZNF225 MRPS15P2
GH19I043667 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -29.4 -29431 4.2 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 E2F8 PLAUR ZNF45 ZNF180 ZNF225 ZNF224 ZNF155 ZNF284 ZNF234 ZNF283 ZNF235
GH19I043798 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 10.3 -159.2 -159178 1.6 ZNF133 SIN3A ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 KLF13 SP3 PIR46459 ZNF180 ZNF45 ZNF225 ZNF224 ZNF234 ZNF284 ZNF223 ZNF227 ZNF226
GH19I043634 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +4.3 4251 2.7 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ETS1 GLIS2 ZNF143 ATF7 KAT8 LOC105372410 CADM4 PINLYP LYPD5 ZNF221 ZNF575 ZNF223 ZNF224 ZNF428 ZNF284
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CADM4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CADM4 Gene

Genomic Locations for CADM4 Gene
17,473 bases
Minus strand

Genomic View for CADM4 Gene

Genes around CADM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM4 Gene

Proteins for CADM4 Gene

  • Protein details for CADM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell adhesion molecule 4
    Protein Accession:
    Secondary Accessions:
    • B2R7L5
    • Q9Y4A4

    Protein attributes for CADM4 Gene

    388 amino acids
    Molecular mass:
    42785 Da
    Quaternary structure:
    • Monomer and homodimer.
    • Sequence=AAC32740.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CADM4 Gene

Post-translational modifications for CADM4 Gene

Other Protein References for CADM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CADM4 Gene

Domains & Families for CADM4 Gene

Suggested Antigen Peptide Sequences for CADM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nectin family.
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM4: view

Function for CADM4 Gene

Molecular function for CADM4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.

Phenotypes From GWAS Catalog for CADM4 Gene

Gene Ontology (GO) - Molecular Function for CADM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with CADM4: view
genes like me logo Genes that share phenotypes with CADM4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CADM4 Gene

Localization for CADM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CADM4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CADM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with CADM4: view

Pathways & Interactions for CADM4 Gene

SuperPathways for CADM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CADM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
genes like me logo Genes that share ontologies with CADM4: view

No data available for Pathways by source and SIGNOR curated interactions for CADM4 Gene

Drugs & Compounds for CADM4 Gene

(2) Drugs for CADM4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Magnesium Approved Nutra 0
genes like me logo Genes that share compounds with CADM4: view

Transcripts for CADM4 Gene

mRNA/cDNA for CADM4 Gene

Unigene Clusters for CADM4 Gene

Cell adhesion molecule 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CADM4 Gene

No ASD Table

Relevant External Links for CADM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CADM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CADM4 Gene

mRNA differential expression in normal tissues according to GTEx for CADM4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.8) and Nerve - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for CADM4 Gene

This gene is overexpressed in Spinal cord (18.4), Frontal cortex (17.8), Cerebrospinal fluid (6.8), Urine (6.5), and Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CADM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CADM4 Gene:


SOURCE GeneReport for Unigene cluster for CADM4 Gene:


mRNA Expression by UniProt/SwissProt for CADM4 Gene:

Tissue specificity: Expressed in brain, prostate, brain, kidney and some other organs.

Evidence on tissue expression from TISSUES for CADM4 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CADM4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CADM4 Gene

Orthologs for CADM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CADM4 33 34
  • 99.55 (n)
(Bos Taurus)
Mammalia CADM4 33 34
  • 92.18 (n)
(Canis familiaris)
Mammalia CADM4 33 34
  • 92.14 (n)
(Mus musculus)
Mammalia Cadm4 33 16 34
  • 90.46 (n)
(Rattus norvegicus)
Mammalia Cadm4 33
  • 89.86 (n)
(Ornithorhynchus anatinus)
Mammalia CADM4 34
  • 89 (a)
(Monodelphis domestica)
Mammalia CADM4 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488420 33
  • 68.5 (n)
Str.15421 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.28976 33
(Danio rerio)
Actinopterygii cadm4 33 34
  • 63.36 (n)
Species where no ortholog for CADM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM4 Gene

Gene Tree for CADM4 (if available)
Gene Tree for CADM4 (if available)

Paralogs for CADM4 Gene

Paralogs for CADM4 Gene

(3) SIMAP similar genes for CADM4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CADM4: view

Variants for CADM4 Gene

Sequence variations from dbSNP and Humsavar for CADM4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000039450 -- 43,625,744(-) C/G intron_variant
rs1000175877 -- 43,639,337(-) G/C intron_variant
rs1000551131 -- 43,632,576(-) G/A/C intron_variant
rs1000587602 -- 43,624,494(-) G/T intron_variant
rs1000675266 -- 43,638,984(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CADM4 Gene

Variant ID Type Subtype PubMed ID
esv23415 CNV gain 19812545
esv2670496 CNV deletion 23128226
esv2718611 CNV deletion 23290073
nsv579852 CNV loss 21841781
nsv833839 CNV loss 17160897

Variation tolerance for CADM4 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CADM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM4 Gene

Disorders for CADM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CADM4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal clear cell carcinoma
  • clear cell carcinoma of kidney
cleft lip/palate-ectodermal dysplasia syndrome
  • clped1
- elite association - COSMIC cancer census association via MalaCards
Search CADM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CADM4

genes like me logo Genes that share disorders with CADM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CADM4 Gene

Publications for CADM4 Gene

  1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PMID: 11536053) Fukuhara H … Murakami Y (Oncogene 2001) 2 3 4 22 58
  2. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. (PMID: 16261159) Williams YN … Murakami Y (Oncogene 2006) 3 4 58
  3. Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression. (PMID: 28921546) Rifatbegovic F … Ambros PF (International journal of cancer 2018) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2. (PMID: 28601637) Yamana S … Rikitake Y (Biochemical and biophysical research communications 2017) 3 58

Products for CADM4 Gene

Sources for CADM4 Gene

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