The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016] See more...

Aliases for CADM3 Gene

Aliases for CADM3 Gene

  • Cell Adhesion Molecule 3 2 3 4 5
  • SynCAM3 2 3 4
  • NECL1 2 3 4
  • TSLL1 2 3 4
  • Immunoglobulin Superfamily Member 4B 3 4
  • Synaptic Cell Adhesion Molecule 3 3 4
  • Brain Immunoglobulin Receptor 3 4
  • IGSF4B 3 4
  • Necl-1 2 3
  • BIgR 2 3
  • Dendritic Cell Nectin-Like Protein 1 Short Isoform 3
  • Immunoglobulin Superfamily, Member 4B 2
  • Nectin-Like Protein 1 4
  • TSLC1-Like Protein 1 4
  • Nectin-Like 1 2
  • TSLC1-Like 1 3
  • FLJ10698 2
  • SYNCAM3 4
  • IgSF4B 4
  • NECL-1 4
  • CADM3 5

External Ids for CADM3 Gene

Previous HGNC Symbols for CADM3 Gene

  • IGSF4B

Previous GeneCards Identifiers for CADM3 Gene

  • GC01P157410
  • GC01P157411
  • GC01P130498

Summaries for CADM3 Gene

Entrez Gene Summary for CADM3 Gene

  • The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

GeneCards Summary for CADM3 Gene

CADM3 (Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with CADM3 include Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CADM2.

UniProtKB/Swiss-Prot Summary for CADM3 Gene

  • Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).

Gene Wiki entry for CADM3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CADM3 Gene

Genomics for CADM3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CADM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CADM3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CADM3

Top Transcription factor binding sites by QIAGEN in the CADM3 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • Tal-1beta

Genomic Locations for CADM3 Gene

Genomic Locations for CADM3 Gene
chr1:159,171,592-159,203,313
(GRCh38/hg38)
Size:
31,722 bases
Orientation:
Plus strand
chr1:159,141,377-159,173,103
(GRCh37/hg19)
Size:
31,727 bases
Orientation:
Plus strand

Genomic View for CADM3 Gene

Genes around CADM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM3 Gene

Proteins for CADM3 Gene

  • Protein details for CADM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N126-CADM3_HUMAN
    Recommended name:
    Cell adhesion molecule 3
    Protein Accession:
    Q8N126
    Secondary Accessions:
    • Q8IZQ9
    • Q9NVJ5
    • Q9UJP1

    Protein attributes for CADM3 Gene

    Size:
    398 amino acids
    Molecular mass:
    43300 Da
    Quaternary structure:
    • Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).
    SequenceCaution:
    • Sequence=BAA91756.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CADM3 Gene

    Alternative splice isoforms for CADM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CADM3 Gene

Post-translational modifications for CADM3 Gene

  • Glycosylation at Asn290
  • Modification sites at PhosphoSitePlus

Other Protein References for CADM3 Gene

No data available for DME Specific Peptides for CADM3 Gene

Domains & Families for CADM3 Gene

Gene Families for CADM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CADM3 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin subtype
  • CD80-like C2-set immunoglobulin
  • Neurexin/syndecan/glycophorin C
ProtoNet:

Suggested Antigen Peptide Sequences for CADM3 Gene

GenScript: Design optimal peptide antigens:
  • TSLC1-like protein 1 (CADM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N126

UniProtKB/Swiss-Prot:

CADM3_HUMAN :
  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
  • Belongs to the nectin family.
Domain:
  • The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM3: view

Function for CADM3 Gene

Molecular function for CADM3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
UniProtKB/Swiss-Prot Induction:
Markedly in glioma cell lines and prostate cancer cell lines.

Phenotypes From GWAS Catalog for CADM3 Gene

Gene Ontology (GO) - Molecular Function for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity ISS 12826663
genes like me logo Genes that share ontologies with CADM3: view
genes like me logo Genes that share phenotypes with CADM3: view

Animal Models for CADM3 Gene

MGI Knock Outs for CADM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CADM3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CADM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CADM3 Gene

Localization for CADM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM3 Gene

Cell membrane. Single-pass type I membrane protein. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CADM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
cytosol 1
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction ISS 12826663
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CADM3: view

Pathways & Interactions for CADM3 Gene

genes like me logo Genes that share pathways with CADM3: view

Gene Ontology (GO) - Biological Process for CADM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12826663
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12826663
GO:0008104 protein localization IEA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CADM3: view

No data available for SIGNOR curated interactions for CADM3 Gene

Drugs & Compounds for CADM3 Gene

(1) Drugs for CADM3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with CADM3: view

Transcripts for CADM3 Gene

mRNA/cDNA for CADM3 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CADM3

Alternative Splicing Database (ASD) splice patterns (SP) for CADM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for CADM3 Gene

GeneLoc Exon Structure for
CADM3

Expression for CADM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CADM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.4) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for CADM3 Gene

This gene is overexpressed in Frontal cortex (26.9), Cerebrospinal fluid (13.7), Spinal cord (8.9), and Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CADM3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CADM3

SOURCE GeneReport for Unigene cluster for CADM3 Gene:

Hs.365689

mRNA Expression by UniProt/SwissProt for CADM3 Gene:

Q8N126-CADM3_HUMAN
Tissue specificity: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.

Evidence on tissue expression from TISSUES for CADM3 Gene

  • Nervous system(5)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with CADM3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CADM3 Gene

Orthologs for CADM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CADM3 30 31
  • 99.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CADM3 30 31
  • 90.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CADM3 30 31
  • 89.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cadm3 30 17 31
  • 89.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cadm3 30
  • 88.97 (n)
Oppossum
(Monodelphis domestica)
Mammalia CADM3 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CADM3 31
  • 51 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CADM3 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490204 30
  • 64.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia necl1-pending-prov 30
Zebrafish
(Danio rerio)
Actinopterygii cadm3 30 31
  • 59.58 (n)
OneToOne
Species where no ortholog for CADM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CADM3 Gene

ENSEMBL:
Gene Tree for CADM3 (if available)
TreeFam:
Gene Tree for CADM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CADM3: view image

Paralogs for CADM3 Gene

(4) SIMAP similar genes for CADM3 Gene using alignment to 1 proteins:

  • CADM3_HUMAN
genes like me logo Genes that share paralogs with CADM3: view

Variants for CADM3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CADM3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs193920866 Uncertain Significance: Malignant tumor of prostate 159,192,730(+) G/C MISSENSE_VARIANT
rs3026987 - p.Arg162Trp

Additional dbSNP identifiers (rs#s) for CADM3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CADM3 Gene

Variant ID Type Subtype PubMed ID
nsv952221 CNV deletion 24416366

Variation tolerance for CADM3 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CADM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CADM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM3 Gene

Disorders for CADM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CADM3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cleft lip/palate-ectodermal dysplasia syndrome
  • clped1
- elite association - COSMIC cancer census association via MalaCards
Search CADM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CADM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CADM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CADM3 Gene

Publications for CADM3 Gene

  1. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. (PMID: 11536053) Fukuhara H … Murakami Y (Oncogene 2001) 2 3 4 23
  2. Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. (PMID: 16467305) Dong X … Rao Z (The Journal of biological chemistry 2006) 3 4 23
  3. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. (PMID: 15893517) Zhou Y … Yuan J (Biochimica et biophysica acta 2005) 3 4 23
  4. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. (PMID: 22291609) Naitza S … Cucca F (PLoS genetics 2012) 3 41
  5. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. (PMID: 19565570) Raveh S … Ben-Ze'ev A (Journal of cellular biochemistry 2009) 3 23

Products for CADM3 Gene

Sources for CADM3 Gene