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Aliases for CADM2 Gene

Aliases for CADM2 Gene

  • Cell Adhesion Molecule 2 2 3 5
  • Immunoglobulin Superfamily Member 4D 3 4
  • Synaptic Cell Adhesion Molecule 2 3 4
  • Nectin-Like Protein 3 3 4
  • Nectin-Like 3 2 3
  • SynCAM 2 3 4
  • Necl-3 3 4
  • IGSF4D 3 4
  • NECL3 3 4
  • Immunoglobulin Superfamily, Member 4D 2
  • SynCAM2 3

External Ids for CADM2 Gene

Previous HGNC Symbols for CADM2 Gene

  • IGSF4D

Previous GeneCards Identifiers for CADM2 Gene

  • GC03P085092
  • GC03P085858

Summaries for CADM2 Gene

Entrez Gene Summary for CADM2 Gene

  • This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CADM2 Gene

CADM2 (Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell junction organization. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot for CADM2 Gene

  • Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

Additional gene information for CADM2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CADM2 Gene

Genomics for CADM2 Gene

GeneHancer (GH) Regulatory Elements for CADM2 Gene

Promoters and enhancers for CADM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I084958 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 555.2 +0.2 197 2.2 CTCF MXI1 PKNOX1 FOXA2 SUZ12 SAP130 DDX20 INSM2 ZNF223 ZNF76 CADM2 GC03P085012
GH03I084964 Enhancer 0.5 ENCODE 5 +6.3 6262 1 CTCF USF1 POLR2A RAD21 CHD2 CADM2 GC03P085012
GH03I085109 Enhancer 0.2 FANTOM5 4.6 +150.7 150657 0.3 CADM2 GC03P085089 GC03P085129
GH03I085071 Enhancer 0.2 FANTOM5 2 +112.5 112458 0.1 GC03M085046 CADM2 GC03P085012
GH03I085161 Enhancer 0.6 ENCODE 0.1 +202.8 202764 1.1 FOXA2 JUN CEBPB EP300 FOXA1 SP1 JUND GATA3 STAT3 FOS GC03M085156 GC03P085129 CADM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CADM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CADM2 gene promoter:

Genomic Locations for CADM2 Gene

Genomic Locations for CADM2 Gene
1,115,449 bases
Plus strand

Genomic View for CADM2 Gene

Genes around CADM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CADM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CADM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CADM2 Gene

Proteins for CADM2 Gene

  • Protein details for CADM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell adhesion molecule 2
    Protein Accession:
    Secondary Accessions:
    • G3XHN7
    • G3XHN8
    • Q3KQY9
    • Q658Q7
    • Q8IZP8

    Protein attributes for CADM2 Gene

    435 amino acids
    Molecular mass:
    47554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CADM2 Gene


neXtProt entry for CADM2 Gene

Post-translational modifications for CADM2 Gene

  • Glycosylation at posLast=3131, posLast=5151, and Asn291
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CADM2 Gene

Domains & Families for CADM2 Gene

Suggested Antigen Peptide Sequences for CADM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nectin family.
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CADM2: view

Function for CADM2 Gene

Molecular function for CADM2 Gene

UniProtKB/Swiss-Prot Function:
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

Phenotypes From GWAS Catalog for CADM2 Gene

Gene Ontology (GO) - Molecular Function for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with CADM2: view
genes like me logo Genes that share phenotypes with CADM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CADM2

miRNA for CADM2 Gene

miRTarBase miRNAs that target CADM2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CADM2 Gene

Localization for CADM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CADM2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CADM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CADM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CADM2 Gene

Pathways & Interactions for CADM2 Gene

genes like me logo Genes that share pathways with CADM2: view

Pathways by source for CADM2 Gene

Interacting Proteins for CADM2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
Selected Interacting proteins: ENSP00000384193 Q8N3J6-CADM2_HUMAN for CADM2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CADM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CADM2: view

No data available for SIGNOR curated interactions for CADM2 Gene

Drugs & Compounds for CADM2 Gene

No Compound Related Data Available

Transcripts for CADM2 Gene

mRNA/cDNA for CADM2 Gene

Unigene Clusters for CADM2 Gene

Cell adhesion molecule 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CADM2 Gene

No ASD Table

Relevant External Links for CADM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CADM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CADM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CADM2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for CADM2 Gene

This gene is overexpressed in Retina (29.3) and Frontal cortex (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CADM2 Gene

Protein tissue co-expression partners for CADM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CADM2 Gene:


SOURCE GeneReport for Unigene cluster for CADM2 Gene:


Evidence on tissue expression from TISSUES for CADM2 Gene

  • Nervous system(4.9)
  • Stomach(4)
genes like me logo Genes that share expression patterns with CADM2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CADM2 Gene

Orthologs for CADM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CADM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CADM2 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia CADM2 33 34
  • 95.4 (n)
(Bos Taurus)
Mammalia CADM2 33 34
  • 94.79 (n)
(Monodelphis domestica)
Mammalia CADM2 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia CADM2 34
  • 92 (a)
(Mus musculus)
Mammalia Cadm2 33 16 34
  • 91.56 (n)
(Rattus norvegicus)
Mammalia Cadm2 33
  • 91.39 (n)
(Gallus gallus)
Aves CADM2 33 34
  • 84.92 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
-- 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cadm2 33
  • 77.29 (n)
(Danio rerio)
Actinopterygii cadm2a 34
  • 70 (a)
cadm2b 33 34
  • 68.03 (n)
zgc66339 33
Species where no ortholog for CADM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CADM2 Gene

Gene Tree for CADM2 (if available)
Gene Tree for CADM2 (if available)

Paralogs for CADM2 Gene

Paralogs for CADM2 Gene

(7) SIMAP similar genes for CADM2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CADM2: view

Variants for CADM2 Gene

Sequence variations from dbSNP and Humsavar for CADM2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000000101 -- 85,651,351(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000002058 -- 85,648,598(+) TTT/TT genic_upstream_transcript_variant, intron_variant
rs1000003121 -- 85,459,987(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000007330 -- 85,086,930(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000009314 -- 85,740,123(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CADM2 Gene

Variant ID Type Subtype PubMed ID
dgv1388e212 CNV loss 25503493
dgv1389e212 CNV loss 25503493
dgv610n27 CNV loss 19166990
dgv611n27 CNV loss 19166990
dgv8422n54 CNV loss 21841781
dgv8423n54 CNV gain 21841781
dgv8424n54 CNV loss 21841781
dgv8425n54 CNV loss 21841781
dgv907e214 CNV loss 21293372
esv1692963 CNV deletion 17803354
esv1739393 CNV insertion 17803354
esv22210 CNV loss 19812545
esv2646105 CNV deletion 19546169
esv2657670 CNV deletion 23128226
esv2662517 CNV deletion 23128226
esv2671756 CNV deletion 23128226
esv2725621 CNV deletion 23290073
esv2725622 CNV deletion 23290073
esv2725623 CNV deletion 23290073
esv2762338 CNV gain 21179565
esv3305965 CNV mobile element insertion 20981092
esv3308991 CNV mobile element insertion 20981092
esv3398815 CNV insertion 20981092
esv3429186 CNV insertion 20981092
esv3433915 CNV insertion 20981092
esv3568882 CNV loss 25503493
esv3596829 CNV loss 21293372
esv3596830 CNV loss 21293372
esv3596831 CNV loss 21293372
esv3596832 CNV loss 21293372
esv3596833 CNV loss 21293372
esv3596834 CNV loss 21293372
esv3596835 CNV loss 21293372
esv3596836 CNV loss 21293372
esv3596837 CNV loss 21293372
esv3596838 CNV loss 21293372
esv3596839 CNV loss 21293372
esv3596841 CNV loss 21293372
esv3596842 CNV loss 21293372
esv3596844 CNV loss 21293372
esv3596845 CNV loss 21293372
esv3596846 CNV loss 21293372
esv3596847 CNV loss 21293372
esv3596850 CNV loss 21293372
esv3893737 CNV loss 25118596
nsv1000793 CNV gain 25217958
nsv1001124 CNV loss 25217958
nsv1002058 CNV gain 25217958
nsv1002139 CNV loss 25217958
nsv1006141 CNV loss 25217958
nsv1009804 CNV loss 25217958
nsv1009927 CNV loss 25217958
nsv1010140 CNV gain 25217958
nsv1123667 CNV deletion 24896259
nsv1136752 CNV deletion 24896259
nsv1141439 CNV duplication 24896259
nsv1142360 CNV tandem duplication 24896259
nsv460748 CNV loss 19166990
nsv460753 CNV loss 19166990
nsv470716 CNV loss 18288195
nsv470727 CNV gain 18288195
nsv471620 CNV loss 15918152
nsv472397 CNV novel sequence insertion 20440878
nsv474072 CNV novel sequence insertion 20440878
nsv522622 CNV loss 19592680
nsv522784 CNV loss 19592680
nsv522825 CNV loss 19592680
nsv526621 CNV loss 19592680
nsv527642 CNV loss 19592680
nsv590897 CNV loss 21841781
nsv590899 CNV loss 21841781
nsv590901 CNV loss 21841781
nsv590904 CNV loss 21841781
nsv590905 CNV loss 21841781
nsv590906 CNV loss 21841781
nsv590907 CNV loss 21841781
nsv590911 CNV loss 21841781
nsv822172 CNV loss 20364138
nsv954354 CNV deletion 24416366
nsv979853 CNV duplication 23825009

Variation tolerance for CADM2 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CADM2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM2 Gene

Disorders for CADM2 Gene

Additional Disease Information for CADM2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CADM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CADM2 Gene

Publications for CADM2 Gene

  1. A novel splicing variant of CADM2 as a protective transcript of psoriasis. (PMID: 21864505) Hiruma A … Oka A (Biochemical and biophysical research communications 2011) 3 4 58
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen EA … Weersma RK (The American journal of gastroenterology 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58
  5. Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. (PMID: 16311015) Biederer T (Genomics 2006) 3 22 58

Products for CADM2 Gene

Sources for CADM2 Gene

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