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Aliases for CADM1 Gene
Aliases for CADM1 Gene
- Cell Adhesion Molecule 1 2 3 4 5
- Tumor Suppressor In Lung Cancer 1 2 3 4
- IGSF4A 2 3 4
- SYNCAM 2 3 4
- NECL2 2 3 4
- Spermatogenic Immunoglobulin Superfamily 3 4
- Immunoglobulin Superfamily Member 4 3 4
- Synaptic Cell Adhesion Molecule 3 4
- Nectin-Like Protein 2 3 4
- Nectin-Like 2 2 3
- Necl-2 2 3
- TSLC-1 3 4
- IGSF4 3 4
- RA175 2 3
- TSLC1 3 4
External Ids for CADM1 Gene
- HGNC: 5951
- Entrez Gene: 23705
- Ensembl: ENSG00000182985
- OMIM: 605686
- UniProtKB: Q9BY67
Previous HGNC Symbols for CADM1 Gene
- TSLC1
- IGSF4
Previous GeneCards Identifiers for CADM1 Gene
- GC11M114551
- GC11M115044
- GC11M110979
Summaries for CADM1 Gene
GeneCards Summary for CADM1 Gene
CADM1 (Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CADM1 include Retroperitoneal Fibrosis and Acute Myeloid Leukemia With T(9;11)(P22;Q23). Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding. An important paralog of this gene is CADM2.
UniProtKB/Swiss-Prot Summary for CADM1 Gene
-
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246).
Additional gene information for CADM1 Gene
- HGNC(5951)
- Entrez Gene(23705)
- Ensembl(ENSG00000182985)
- OMIM(605686)
- UniProtKB(Q9BY67)
- Open Targets Platform(ENSG00000182985)
- Monarch Initiative
- Search for CADM1 at DataMed
- Search for CADM1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CADM1 Gene
Genomics for CADM1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CADM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CADM1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CADM1
- Top Transcription factor binding sites by QIAGEN in the CADM1 gene promoter:
-
- c-Rel
- E47
- GATA-3
- Hand1
- MyoD
- NF-AT
- NF-AT1
- p53
Genomic Locations for CADM1 Gene
Genomic Locations for CADM1 Gene
- chr11:115,169,218-115,504,957
- (GRCh38/hg38)
- Size:
- 335,740 bases
- Orientation:
- Minus strand
- chr11:115,039,938-115,375,675
- (GRCh37/hg19)
- Size:
- 335,738 bases
- Orientation:
- Minus strand
Genomic View for CADM1 Gene
Genes around CADM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
CADM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CADM1 Gene
Proteins for CADM1 Gene
-
Protein details for CADM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BY67-CADM1_HUMAN
- Recommended name:
- Cell adhesion molecule 1
- Protein Accession:
- Q9BY67
- A4FVB5
- F5H0J4
- H0YGA7
- H1ZZV9
- H1ZZW1
- H1ZZW2
- Q86WB8
- Q8N2F4
- X5D2C8
Protein attributes for CADM1 Gene
- Size:
- 442 amino acids
- Molecular mass:
- 48509 Da
- Quaternary structure:
-
- Homodimer (via Ig-like V-type domain) (PubMed:12050160, PubMed:23871486). Interacts with FARP1 (By similarity). Interacts (via Ig-like V-type domain) with CRTAM (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15811952, PubMed:15781451, PubMed:23871486). Interacts (via C-terminus) with EPB41L3/DAL1 (PubMed:12234973, PubMed:21131357). The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton (PubMed:12234973). Interacts (via C-terminus) with MPP2 (via PDZ domain) (By similarity). Interacts (via C-terminus) with MPP3 (via PDZ domain) (PubMed:13679854). Interacts (via C-terminus) with MPP6 (via PDZ domain) (By similarity).
- (Microbial infection) Interacts with herpes virus 8 proteins vFLIP and vGPCR; these interactions are essential for NF-kappa-B activation.
- SequenceCaution:
-
- Sequence=AAI25103.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for CADM1 Gene
Post-translational modifications for CADM1 Gene
Other Protein References for CADM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SYNCAM / CADM1 Antibody (LS-B5232) and SYNCAM / CADM1 Antibody (LS-B246)
-
Custom Antibody ServicesOriGene Antibodies for CADM1
- Novus Biologicals Antibodies for CADM1
-
Abcam antibodies for CADM1
- Invitrogen Antibodies for CADM1 (AFLGC-CADM1)
- Sino Biological Antibodies for CADM1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CADM1
- Origene Custom Protein Services for CADM1
- Sino Biological Recombinant Proteins for CADM1
- Sino Biological Cell Lysates for CADM1
- ProSpec Recombinant Proteins for CADM1
-
ProSci Proteins for CADM1
-
Abcam proteins for CADM1
Assay Products
- antibodies-online: Show 10 available CADM1 Elisa Kits ranked by validation data
- Compare Top CADM1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for CADM1
No data available for DME Specific Peptides for CADM1 Gene
Domains & Families for CADM1 Gene
Gene Families for CADM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CADM1 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- CD80-like C2-set immunoglobulin
- Neurexin/syndecan/glycophorin C
- ProtoNet:
Suggested Antigen Peptide Sequences for CADM1 Gene
- GenScript: Design optimal peptide antigens:
-
- CADM1 protein (A0A4Z1_HUMAN)
- CADM1 protein (A4FVB5_HUMAN)
- Tumor suppressor in lung cancer 1 (CADM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BY67UniProtKB/Swiss-Prot:
CADM1_HUMAN :- The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
- Belongs to the nectin family.
- Domain:
-
- The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
- Family:
-
- Belongs to the nectin family.
Function for CADM1 Gene
Molecular function for CADM1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246).
Phenotypes From GWAS Catalog for CADM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | ISS | 12826663 |
| GO:0005515 | protein binding | IPI | 12234973 |
| GO:0030165 | PDZ domain binding | ISS | 12826663 |
| GO:0042803 | protein homodimerization activity | ISS | 12826663 |
Phenotypes for CADM1 Gene
- MGI mutant phenotypes for CADM1:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for CADM1:
Animal Models for CADM1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CADM1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CADM1 - Select products 50% OFF >
- * CADM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CADM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CADM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CADM1
miRNA for CADM1 Gene
- miRTarBase miRNAs that target CADM1
-
- hsa-miR-15a-5p (MIRT003888)
- mmu-miR-16-5p (MIRT004105)
- mmu-miR-15a-5p (MIRT004106)
- hsa-miR-192-5p (MIRT004167)
- hsa-miR-16-5p (MIRT004382)
- mmu-miR-7b-5p (MIRT009460)
- mmu-miR-181a-5p (MIRT014381)
- hsa-miR-26b-5p (MIRT029576)
- hsa-miR-877-3p (MIRT036901)
- hsa-miR-484 (MIRT042379)
- hsa-miR-182-5p (MIRT054846)
- hsa-let-7a-2-3p (MIRT058253)
- hsa-let-7g-3p (MIRT058254)
- hsa-miR-214-3p (MIRT438815)
- hsa-miR-486-5p (MIRT438847)
- hsa-miR-4644 (MIRT494391)
- hsa-miR-4306 (MIRT494392)
- hsa-miR-185-5p (MIRT494393)
- hsa-miR-4479 (MIRT494394)
- hsa-miR-6770-5p (MIRT494395)
- hsa-miR-361-3p (MIRT494396)
- hsa-miR-4428 (MIRT494397)
- hsa-miR-6885-3p (MIRT538744)
- hsa-miR-1273e (MIRT538745)
- hsa-miR-6892-5p (MIRT538746)
- hsa-miR-4327 (MIRT538747)
- hsa-miR-6512-5p (MIRT538748)
- hsa-miR-4475 (MIRT538749)
- hsa-miR-4484 (MIRT538750)
- hsa-miR-6768-3p (MIRT538751)
- hsa-miR-548an (MIRT538752)
- hsa-miR-3692-3p (MIRT574839)
- hsa-miR-4703-3p (MIRT574840)
- hsa-miR-140-3p (MIRT574841)
- hsa-miR-7852-3p (MIRT574842)
- hsa-miR-144-3p (MIRT574843)
- hsa-miR-101-3p (MIRT574844)
- hsa-miR-6732-3p (MIRT574845)
- hsa-miR-652-5p (MIRT574846)
- hsa-miR-10b-5p (MIRT574847)
- hsa-miR-10a-5p (MIRT574848)
- mmu-miR-126a-5p (MIRT584515)
- hsa-miR-1277-5p (MIRT708154)
- hsa-miR-6083 (MIRT708155)
- hsa-miR-190a-3p (MIRT708156)
- hsa-miR-5011-5p (MIRT708157)
- hsa-miR-7161-3p (MIRT708158)
- hsa-miR-126-3p (MIRT732065)
- hsa-miR-21-5p (MIRT732712)
- rno-miR-21-3p (MIRT734332)
- hsa-miR-302c-5p (MIRT784454)
- hsa-miR-552-5p (MIRT787627)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CADM1
- Browse OriGene Inhibitory RNA Products For CADM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CADM1
Clone Products
- Applied Biological Materials (abm): Clones for CADM1 - Select products 50% OFF >
- * CADM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG222732
- MG222734
- MG222735
- MG222737
- MR222732
- MR222732L3
- MR222732L4
- MR222734
- MR222734L3
- MR222734L4
- MR222735
- MR222735L3
- MR222735L4
- MR222737
- MR222737L3
- MR222737L4
- RC215477
- RC215477L1
- RC215477L2
- RC215477L3
- RC215477L4
- RC224904
- RC224904L3
- RC224904L4
- RC238264
- RC238313
- RC238425
- RG215477
- RG224904
- RR213821
- RR213821L3
- RR213821L4
- MR222732L3V
- MR222732L4V
- MR222734L3V
- MR222734L4V
- MR222735L3V
- MR222735L4V
- MR222737L3V
- MR222737L4V
- RC215477L1V
- RC215477L2V
- RC215477L3V
- RC215477L4V
- RC224904L3V
- RC224904L4V
- RR213821L3V
- RR213821L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CADM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CADM1
Cell Line Products
-
Horizon Cell Lines for CADM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CADM1 Gene
Localization for CADM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CADM1 Gene
- Cell membrane. Single-pass type I membrane protein. Cell junction, synapse. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250 UniProtKB:Q8R5M8}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005911 | cell-cell junction | ISS | 12826663 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016323 | basolateral plasma membrane | ISS | 12826663 |
Pathways & Interactions for CADM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell junction organization | ||
| 2 | Cell adhesion molecules (CAMs) | ||
Pathways by source for CADM1 Gene
5 Reactome pathways for CADM1 Gene
1 KEGG pathway for CADM1 Gene
Interacting Proteins for CADM1 Gene
Selected Interacting proteins:
Q9BY67-CADM1_HUMAN
ENSP00000329797
for CADM1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CADM1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001913 | NOT T cell mediated cytotoxicity | IDA | 15811952 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | ISS | 12826663 |
No data available for SIGNOR curated interactions for CADM1 Gene
Transcripts for CADM1 Gene
mRNA/cDNA for CADM1 Gene
- 5 REFSEQ mRNAs :
- 34 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000545960 630 nts (view in UCSC)
- ENST00000452722 8588 nts (view in UCSC)
- ENST00000537140 1646 nts (view in UCSC)
- ENST00000542447 4223 nts (view in UCSC)
- ENST00000537058 3550 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CADM1 - Select products 50% OFF >
- * CADM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CADM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CADM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CADM1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CADM1
- Browse OriGene Inhibitory RNA Products For CADM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CADM1
Clone Products
- Applied Biological Materials (abm): Clones for CADM1 - Select products 50% OFF >
- * CADM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG222732
- MG222734
- MG222735
- MG222737
- MR222732
- MR222732L3
- MR222732L4
- MR222734
- MR222734L3
- MR222734L4
- MR222735
- MR222735L3
- MR222735L4
- MR222737
- MR222737L3
- MR222737L4
- RC215477
- RC215477L1
- RC215477L2
- RC215477L3
- RC215477L4
- RC224904
- RC224904L3
- RC224904L4
- RC238264
- RC238313
- RC238425
- RG215477
- RG224904
- RR213821
- RR213821L3
- RR213821L4
- MR222732L3V
- MR222732L4V
- MR222734L3V
- MR222734L4V
- MR222735L3V
- MR222735L4V
- MR222737L3V
- MR222737L4V
- RC215477L1V
- RC215477L2V
- RC215477L3V
- RC215477L4V
- RC224904L3V
- RC224904L4V
- RR213821L3V
- RR213821L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CADM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CADM1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for CADM1 Gene
- GeneLoc Exon Structure for
- CADM1
Expression for CADM1 Gene
mRNA differential expression in normal tissues according to GTEx for CADM1 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.3).
This gene is overexpressed in Retina (11.8), Serum (9.6), Testis (7.2), Brain (6.5), and Fetal Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CADM1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CADM1
SOURCE GeneReport for Unigene cluster for CADM1 Gene:
Hs.370510Evidence on tissue expression from TISSUES for CADM1 Gene
- Nervous system(4.9)
- Liver(4.6)
- Pancreas(3.9)
- Lung(3.6)
- Eye(3.6)
- Heart(3.1)
- Blood(2.9)
- Lymph node(2.9)
- Kidney(2.8)
- Skin(2.8)
- Muscle(2.8)
- Intestine(2.5)
- Spleen(2.5)
- Thyroid gland(2.4)
- Stomach(2.3)
- Adrenal gland(2.2)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for CADM1
-
OriGene qPCR primer pairs and template standards for CADM1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CADM1 Gene
Orthologs for CADM1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CADM1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CADM1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cadm1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cadm1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | CADM1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CADM1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CADM1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CADM1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CADM1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cadm1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14858 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cadm1b 30 31 |
|
OneToMany | |
| cadm1a 31 |
|
OneToMany |
- Species where no ortholog for CADM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CADM1 Gene
- ENSEMBL:
- Gene Tree for CADM1 (if available)
- TreeFam:
- Gene Tree for CADM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CADM1: view image
Paralogs for CADM1 Gene
Paralogs for CADM1 Gene
(7) SIMAP similar genes for CADM1 Gene using alignment to 11 proteins:
- CADM1_HUMAN
- A0A4Z1_HUMAN
- F5H0H5_HUMAN
- F5H125_HUMAN
- F5H372_HUMAN
- F5H8J9_HUMAN
- H0YG94_HUMAN
- H1ZZW3_HUMAN
- H1ZZW4_HUMAN
- H1ZZW5_HUMAN
- H1ZZW6_HUMAN
Variants for CADM1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CADM1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710449 | Benign: not provided | 115,504,383(-) | T/C | SYNONYMOUS_VARIANT | |
| 718089 | Benign: not provided | 115,214,699(-) | A/G | SYNONYMOUS_VARIANT | |
| 719362 | Benign: not provided | 115,214,681(-) | A/G | SYNONYMOUS_VARIANT | |
| 727360 | Likely Benign: not provided | 115,178,666(-) | C/T | SYNONYMOUS_VARIANT | |
| 733505 | Benign: not provided | 115,209,591(-) | ATGGTGGTGG/A | INFRAME_DELETION,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1078257 | CNV | insertion | 17803354 |
| esv2659168 | CNV | deletion | 23128226 |
| esv3627810 | CNV | loss | 21293372 |
| esv3627811 | CNV | loss | 21293372 |
| esv3627812 | CNV | loss | 21293372 |
| esv7788 | CNV | gain | 19470904 |
| nsv1042473 | CNV | loss | 25217958 |
| nsv1050802 | CNV | loss | 25217958 |
| nsv1122669 | CNV | deletion | 24896259 |
| nsv1134177 | CNV | deletion | 24896259 |
| nsv1134178 | CNV | deletion | 24896259 |
| nsv1138077 | CNV | deletion | 24896259 |
| nsv468871 | CNV | loss | 19166990 |
| nsv502 | CNV | insertion | 18451855 |
| nsv525753 | CNV | loss | 19592680 |
| nsv556446 | CNV | loss | 21841781 |
| nsv832278 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.39;
54.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CADM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CADM1 Gene
Disorders for CADM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retroperitoneal fibrosis |
|
|
| acute myeloid leukemia with t(9;11)(p22;q23) |
|
|
| lung cancer |
|
|
| adult t-cell leukemia |
|
|
| neurofibromatosis, type ii |
|
Search CADM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CADM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CADM1 Gene
Publications for CADM1 Gene
- The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PMID: 15811952) Boles KS … Colonna M (Blood 2005) 3 4 23
- Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PMID: 15781451) Galibert L … Yan W (The Journal of biological chemistry 2005) 3 4 23
- Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. (PMID: 15184878) Mao X … Ghosh HP (Oncogene 2004) 3 4 23
- Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. (PMID: 12925956) Fukami T … Murakami Y (International journal of cancer 2003) 3 4 23
- Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. (PMID: 13679854) Fukuhara H … Masvuda M (Oncogene 2003) 3 4 23
ExternalLinks
Products for CADM1 Gene
- View all 4 R&D Systems CADM1 (IGSF4A/SynCAM1) Products
- View all R&D Systems CADM1 (IGSF4A/SynCAM1) Proteins and Enzymes
- View all 2 R&D Systems CADM1 (IGSF4A/SynCAM1) Primary Antibodies
- View all R&D Systems CADM1 (IGSF4A/SynCAM1) cDNA Clones
- Learn more about R&D Systems custom CADM1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CADM1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CADM1
- Origene Custom Protein Services for CADM1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CADM1
- Browse OriGene Inhibitory RNA Products For CADM1
- OriGene qPCR primer pairs for CADM1
- OriGene qPCR primer pairs and template standards for CADM1
- OriGene CRISPR knockouts for CADM1
- MG222732
- MG222734
- MG222735
- MG222737
- MR222732
- MR222732L3
- MR222732L4
- MR222734
- MR222734L3
- MR222734L4
- MR222735
- MR222735L3
- MR222735L4
- MR222737
- MR222737L3
- MR222737L4
- RC215477
- RC215477L1
- RC215477L2
- RC215477L3
- RC215477L4
- RC224904
- RC224904L3
- RC224904L4
- RC238264
- RC238313
- RC238425
- RG215477
- RG224904
- RR213821
- RR213821L3
- RR213821L4
- MR222732L3V
- MR222732L4V
- MR222734L3V
- MR222734L4V
- MR222735L3V
- MR222735L4V
- MR222737L3V
- MR222737L4V
- RC215477L1V
- RC215477L2V
- RC215477L3V
- RC215477L4V
- RC224904L3V
- RC224904L4V
- RR213821L3V
- RR213821L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CADM1
- Sino Biological Human cDNA Clone for CADM1
- Sino Biological Recombinant Proteins for CADM1
- Sino Biological Cell Lysates for CADM1
- Sino Biological Antibodies for CADM1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CADM1
- Novus Biologicals proteins and lysates for CADM1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CADM1
- Abcam proteins for CADM1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CADM1
- Taconic Biosciences Mouse Models for CADM1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CADM1 (AFLGC-CADM1)
- VectorBuilder Custom and pre-made DNA vectors for CADM1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CADM1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CADM1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CADM1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CADM1
- antibodies-online: Show 27 available CADM1 Antibodies ranked by validation data
- Compare Top CADM1 Antibodies
- antibodies-online: Show 10 available CADM1 Elisa Kits ranked by validation data
- Compare Top CADM1 Elisa Kits
- Quality Products:
- antibodies-online: Show 16 available CADM1 Proteins ranked by validation data
- Compare Top CADM1 Proteins
- Horizon Cell Lines for CADM1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CADM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CADM1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CADM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CADM1
- Signalway ELISA kits for CADM1
Sources for CADM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB