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CADM1 (Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CADM1 include Retroperitoneal Fibrosis and Acute Myeloid Leukemia With T(9;11)(P22;Q23). Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding. An important paralog of this gene is CADM2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | ISS | 12826663 |
GO:0005515 | protein binding | IPI | 12234973 |
GO:0030165 | PDZ domain binding | ISS | 12826663 |
GO:0042803 | protein homodimerization activity | ISS | 12826663 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005911 | cell-cell junction | ISS | 12826663 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0016323 | basolateral plasma membrane | ISS | 12826663 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell junction organization | ||
2 | Cell adhesion molecules (CAMs) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001913 | NOT T cell mediated cytotoxicity | IDA | 15811952 |
GO:0002376 | immune system process | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | ISS | 12826663 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CADM1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CADM1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cadm1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cadm1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | CADM1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CADM1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CADM1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CADM1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CADM1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cadm1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14858 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cadm1b 30 31 |
|
OneToMany | |
cadm1a 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710449 | Benign: not provided | 115,504,383(-) | T/C | SYNONYMOUS_VARIANT | |
718089 | Benign: not provided | 115,214,699(-) | A/G | SYNONYMOUS_VARIANT | |
719362 | Benign: not provided | 115,214,681(-) | A/G | SYNONYMOUS_VARIANT | |
727360 | Likely Benign: not provided | 115,178,666(-) | C/T | SYNONYMOUS_VARIANT | |
733505 | Benign: not provided | 115,209,591(-) | ATGGTGGTGG/A | INFRAME_DELETION,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1078257 | CNV | insertion | 17803354 |
esv2659168 | CNV | deletion | 23128226 |
esv3627810 | CNV | loss | 21293372 |
esv3627811 | CNV | loss | 21293372 |
esv3627812 | CNV | loss | 21293372 |
esv7788 | CNV | gain | 19470904 |
nsv1042473 | CNV | loss | 25217958 |
nsv1050802 | CNV | loss | 25217958 |
nsv1122669 | CNV | deletion | 24896259 |
nsv1134177 | CNV | deletion | 24896259 |
nsv1134178 | CNV | deletion | 24896259 |
nsv1138077 | CNV | deletion | 24896259 |
nsv468871 | CNV | loss | 19166990 |
nsv502 | CNV | insertion | 18451855 |
nsv525753 | CNV | loss | 19592680 |
nsv556446 | CNV | loss | 21841781 |
nsv832278 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
retroperitoneal fibrosis |
|
|
acute myeloid leukemia with t(9;11)(p22;q23) |
|
|
lung cancer |
|
|
adult t-cell leukemia |
|
|
neurofibromatosis, type ii |
|