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Aliases for CACYBP Gene

Aliases for CACYBP Gene

  • Calcyclin Binding Protein 2 3 5
  • S100A6-Binding Protein 3 4
  • S100A6BP 3 4
  • HCacyBP 3 4
  • SIP 3 4
  • Growth-Inhibiting Gene 5 Protein 3
  • Siah-Interacting Protein (SIP) 3
  • Calcyclin-Binding Protein 3
  • Siah-Interacting Protein 4
  • PNAS-107 3
  • CacyBP 4
  • GIG5 3

External Ids for CACYBP Gene

Previous GeneCards Identifiers for CACYBP Gene

  • GC00U920615
  • GC01P171701
  • GC01P173235
  • GC01P146194

Summaries for CACYBP Gene

Entrez Gene Summary for CACYBP Gene

  • The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CACYBP Gene

CACYBP (Calcyclin Binding Protein) is a Protein Coding gene. Diseases associated with CACYBP include Neuroblastoma. Among its related pathways are Wnt / Hedgehog / Notch and Wnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for CACYBP Gene

  • May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Gene Wiki entry for CACYBP Gene

Additional gene information for CACYBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACYBP Gene

Genomics for CACYBP Gene

GeneHancer (GH) Regulatory Elements for CACYBP Gene

Promoters and enhancers for CACYBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I174996 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 401 6.8 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 PPARGC1A CACYBP LOC105371622 RC3H1 LOC101928696 RNU6-307P PIR47281
GH01I174963 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -31.4 -31415 9.2 HDGF PKNOX1 SMAD1 ARNT FEZF1 IRF4 YY1 ZNF766 JUNB ZNF592 RABGAP1L MRPS14 RNU6-307P CACYBP TNN KIAA0040 LOC101928696
GH01I174938 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -60.3 -60314 1.6 PKNOX1 PRDM6 IKZF1 JUNB ETV6 FEZF1 CACYBP RC3H1 RPS26P12 LOC101928696 RABGAP1L
GH01I175003 Enhancer 0.9 Ensembl dbSUPER 0.8 +4.0 4038 0.4 BCOR ZNF384 RELA ZNF316 NFE2 PRDM10 MAFK SMARCE1 BHLHE40 ZNF407 PIR47281 CACYBP LOC105371622
GH01I175006 Enhancer 0.3 dbSUPER 0.4 +8.7 8675 2.7 POLR2A RABGAP1L LOC101928696 PIR47281 CACYBP ENSG00000206659 GC01M175022
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CACYBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CACYBP gene promoter:

Genomic Locations for CACYBP Gene

Genomic Locations for CACYBP Gene
chr1:174,999,163-175,012,027
(GRCh38/hg38)
Size:
12,865 bases
Orientation:
Plus strand
chr1:174,968,300-174,981,163
(GRCh37/hg19)

Genomic View for CACYBP Gene

Genes around CACYBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACYBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACYBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACYBP Gene

Proteins for CACYBP Gene

  • Protein details for CACYBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB71-CYBP_HUMAN
    Recommended name:
    Calcyclin-binding protein
    Protein Accession:
    Q9HB71
    Secondary Accessions:
    • B2ZWH2
    • B3KSF1
    • O60666
    • Q5R370
    • Q5R371

    Protein attributes for CACYBP Gene

    Size:
    228 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    • Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.
    SequenceCaution:
    • Sequence=AAG23817.1; Type=Frameshift; Positions=203; Evidence={ECO:0000305}; Sequence=BAG52713.1; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CACYBP Gene

    Alternative splice isoforms for CACYBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACYBP Gene

Post-translational modifications for CACYBP Gene

  • Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
  • Ubiquitination at Lys51, posLast=118118, posLast=123123, posLast=146146, posLast=196196, posLast=207207, Lys212, and Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for CACYBP Gene

No data available for DME Specific Peptides for CACYBP Gene

Domains & Families for CACYBP Gene

Gene Families for CACYBP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CACYBP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CACYBP: view

No data available for UniProtKB/Swiss-Prot for CACYBP Gene

Function for CACYBP Gene

Molecular function for CACYBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Gene Ontology (GO) - Molecular Function for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085652
GO:0019904 protein domain specific binding IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0042803 protein homodimerization activity IPI 16085652
genes like me logo Genes that share ontologies with CACYBP: view
genes like me logo Genes that share phenotypes with CACYBP: view

Animal Models for CACYBP Gene

MGI Knock Outs for CACYBP:

Animal Model Products

  • Taconic Biosciences Mouse Models for CACYBP

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CACYBP Gene

Localization for CACYBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACYBP Gene

Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CACYBP gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005641 nuclear envelope lumen IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CACYBP: view

Pathways & Interactions for CACYBP Gene

genes like me logo Genes that share pathways with CACYBP: view

Pathways by source for CACYBP Gene

1 BioSystems pathway for CACYBP Gene
1 KEGG pathway for CACYBP Gene
1 Cell Signaling Technology pathway for CACYBP Gene

Gene Ontology (GO) - Biological Process for CACYBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
GO:0007568 aging IEA --
GO:0045740 positive regulation of DNA replication IEA --
GO:0055007 cardiac muscle cell differentiation IEA --
GO:0060416 response to growth hormone IEA --
genes like me logo Genes that share ontologies with CACYBP: view

No data available for SIGNOR curated interactions for CACYBP Gene

Drugs & Compounds for CACYBP Gene

(1) Drugs for CACYBP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(1) Additional Compounds for CACYBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CACYBP: view

Transcripts for CACYBP Gene

Unigene Clusters for CACYBP Gene

Calcyclin binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACYBP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -
SP6: - - - -

Relevant External Links for CACYBP Gene

GeneLoc Exon Structure for
CACYBP
ECgene alternative splicing isoforms for
CACYBP

Expression for CACYBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CACYBP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CACYBP Gene



Protein tissue co-expression partners for CACYBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CACYBP Gene:

CACYBP

SOURCE GeneReport for Unigene cluster for CACYBP Gene:

Hs.508524

Evidence on tissue expression from TISSUES for CACYBP Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CACYBP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CACYBP Gene

Orthologs for CACYBP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CACYBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CACYBP 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia CACYBP 33 34
  • 93.54 (n)
cow
(Bos Taurus)
Mammalia CACYBP 33 34
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Cacybp 33 16 34
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Cacybp 33
  • 88.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CACYBP 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CACYBP 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves CACYBP 33 34
  • 72.14 (n)
lizard
(Anolis carolinensis)
Reptilia CACYBP 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cacybp 33
  • 70.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia sip-prov 33
zebrafish
(Danio rerio)
Actinopterygii cacybp 33 34
  • 62.31 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4424 33
fruit fly
(Drosophila melanogaster)
Insecta CG3226 33 34
  • 49.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002107 33
  • 49.22 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30070 33
  • 47.18 (n)
rice
(Oryza sativa)
Liliopsida Os01g0757500 33
  • 47.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2662 34
  • 40 (a)
OneToOne
Species where no ortholog for CACYBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CACYBP Gene

ENSEMBL:
Gene Tree for CACYBP (if available)
TreeFam:
Gene Tree for CACYBP (if available)

Paralogs for CACYBP Gene

Pseudogenes.org Pseudogenes for CACYBP Gene

genes like me logo Genes that share paralogs with CACYBP: view

No data available for Paralogs for CACYBP Gene

Variants for CACYBP Gene

Sequence variations from dbSNP and Humsavar for CACYBP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000477940 -- 175,003,222(+) G/A intron_variant
rs1000633641 -- 175,007,863(+) AGATAG/AG intron_variant
rs1000839845 -- 175,000,318(+) T/C 5_prime_UTR_variant, intron_variant
rs1001814361 -- 175,008,384(+) T/A intron_variant
rs1002278217 -- 175,012,159(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CACYBP Gene

Variant ID Type Subtype PubMed ID
nsv1001000 CNV gain 25217958
nsv946511 CNV duplication 23825009

Variation tolerance for CACYBP Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CACYBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CACYBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACYBP Gene

Disorders for CACYBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for CACYBP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CACYBP

genes like me logo Genes that share disorders with CACYBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACYBP Gene

Publications for CACYBP Gene

  1. Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. (PMID: 16085652) Santelli E … Matsuzawa S (The Journal of biological chemistry 2005) 3 4 22 58
  2. Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP). (PMID: 12421809) Matsuzawa S … Ely KR (The Journal of biological chemistry 2003) 2 3 22 58
  3. Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells. (PMID: 12895292) Wu J … Qiang B (Journal of biochemistry and molecular biology 2003) 3 4 22 58
  4. [Cloning and expression of human calcyclin binding protein (hCacyBP) gene]. (PMID: 12006993) Liu WX … Qiang BQ (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2002) 3 4 22 58
  5. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PMID: 11389839) Matsuzawa SI … Reed JC (Molecular cell 2001) 2 3 4 58

Products for CACYBP Gene

Sources for CACYBP Gene

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