Aliases for CACNG8 Gene
- Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8 2 3 5
- Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit 3 4
- Calcium Channel, Voltage-Dependent, Gamma Subunit 8 2 3
- Voltage-Dependent Calcium Channel Gamma-8 Subunit 3 4
- Transmembrane AMPAR Regulatory Protein Gamma-8 3 4
- TARP Gamma-8 3 4
- CACNG8 5
- CACNG6 4
External Ids for CACNG8 Gene
Previous GeneCards Identifiers for CACNG8 Gene
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]
GeneCards Summary for CACNG8 Gene
CACNG8 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8) is a Protein Coding gene. Diseases associated with CACNG8 include Dilated Cardiomyopathy. Among its related pathways are ERK Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG4.
UniProtKB/Swiss-Prot Summary for CACNG8 Gene
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.