Aliases for CACNG7 Gene
- Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7 2 3 5
- Neuronal Voltage-Gated Calcium Channel Gamma-7 Subunit 3 4
- Calcium Channel, Voltage-Dependent, Gamma Subunit 7 2 3
- Voltage-Dependent Calcium Channel Gamma-7 Subunit 3 4
- Transmembrane AMPAR Regulatory Protein Gamma-7 3 4
- TARP Gamma-7 3 4
- CACNG7 5
External Ids for CACNG7 Gene
Previous GeneCards Identifiers for CACNG7 Gene
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]
GeneCards Summary for CACNG7 Gene
CACNG7 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7) is a Protein Coding gene. Diseases associated with CACNG7 include Isolated Growth Hormone Deficiency, Type Ib and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are Presenilin-Mediated Signaling and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity. An important paralog of this gene is CACNG5.
UniProtKB/Swiss-Prot Summary for CACNG7 Gene
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611).