Aliases for CACNG5 Gene
External Ids for CACNG5 Gene
Previous GeneCards Identifiers for CACNG5 Gene
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
GeneCards Summary for CACNG5 Gene
CACNG5 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5) is a Protein Coding gene. Diseases associated with CACNG5 include Bipolar Disorder and Schizophrenia. Among its related pathways are Activation of cAMP-Dependent PKA and Phase 0 - rapid depolarisation. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and ion transmembrane transporter activity. An important paralog of this gene is CACNG7.
UniProtKB/Swiss-Prot Summary for CACNG5 Gene
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).