Aliases for CACNG2 Gene
External Ids for CACNG2 Gene
Previous GeneCards Identifiers for CACNG2 Gene
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability. [provided by RefSeq, Jul 2017]
GeneCards Summary for CACNG2 Gene
CACNG2 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2) is a Protein Coding gene. Diseases associated with CACNG2 include Mental Retardation, Autosomal Dominant 10 and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Presenilin-Mediated Signaling and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and ionotropic glutamate receptor binding. An important paralog of this gene is CACNG3.
UniProtKB/Swiss-Prot Summary for CACNG2 Gene
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.