Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
CACNB3 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3) is a Protein Coding gene. Diseases associated with CACNB3 include Headache and Lambert-Eaton Myasthenic Syndrome. Among its related pathways are Integrin Pathway and Integration of energy metabolism. Gene Ontology (GO) annotations related to this gene include protein kinase binding and high voltage-gated calcium channel activity. An important paralog of this gene is CACNB4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005244 | voltage-gated ion channel activity | IEA | -- |
GO:0005245 | contributes_to voltage-gated calcium channel activity | TAS,IDA | 11160515 |
GO:0005246 | calcium channel regulator activity | ISS | -- |
GO:0005262 | calcium channel activity | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 18535142 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005891 | voltage-gated calcium channel complex | TAS,IDA | 11160515 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | nNOS Signaling in Skeletal Muscle |
BMP Pathway
.44
DREAM Repression and Dynorphin Expression
.44
nNOS Signaling in Skeletal Muscle
.37
|
Caspase Cascade
.36
Calpain Protease Regulates Cellular Mechanics
.31
|
2 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
ITK and TCR Signaling
.54
|
Fc-EpsilonRI Pathway
.49
PDGF Pathway
.39
|
3 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
PKA Signaling
.56
|
4 | CCR5 Pathway in Macrophages |
Androgen Signaling
.52
CCR5 Pathway in Macrophages
.52
|
Chemokine Signaling
.33
|
5 | Sweet Taste Signaling |
Melatonin Signaling
.72
Sweet Taste Signaling
.72
|
Cellular Effects of Sildenafil
.46
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006816 | calcium ion transport | IEA,IDA | 11160515 |
GO:0007268 | chemical synaptic transmission | IBA | 21873635 |
GO:0007528 | neuromuscular junction development | IBA | 21873635 |
GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Nimodipine | Approved, Investigational | Pharma | Activator, Potentiation, Target, inhibitor | Ca2+ channel blocker (L-type) | 42 | |
Safinamide | Approved, Investigational | Pharma | inhibitor | MAO-B inhibitor | 0 | |
Verapamil | Approved | Pharma | Channel blocker, Pore Blocker, Inhibitor, Inhibition, blocker | 134 | ||
Amiodarone | Approved, Investigational | Pharma | Pore Blocker, Target, inhibitor | 138 | ||
Bioallethrin | Approved, Experimental | Pharma | Target, Target, agonist, blocker | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
O-Desmethylverapamil (D-702) |
|
|
Compound | Action | Cas Number |
---|---|---|
Nimodipine | 66085-59-4 | |
Safinamide | MAO-B inhibitor | 133865-89-1 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - |
ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: | |||||||||
SP10: | |||||||||
SP11: | |||||||||
SP12: | |||||||||
SP13: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CACNB3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CACNB3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CACNB3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CACNB3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cacnb3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cacnb3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CACNB3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CACNB3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cacnb3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | cacnb3-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cacnb3b 30 31 |
|
OneToMany | |
cacnb3a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ca-&bgr; 32 |
|
|
|
Ca-beta 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ccb-1 31 32 |
|
OneToMany | |
W10C8.1 32 |
|
|
Disorder | Aliases | PubMed IDs |
---|---|---|
headache |
|
|
lambert-eaton myasthenic syndrome |
|
|
distal hereditary motor neuronopathy type 2 |
|
|
dilated cardiomyopathy |
|
|