CACNB1 Gene (Protein Coding)

Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1

GC17M039173
GIFtS:
44
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three trans... See more...

Aliases for CACNB1 Gene

Aliases for CACNB1 Gene

  • Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1 2 3 5
  • Voltage-Dependent L-Type Calcium Channel Subunit Beta-1 3 4
  • Calcium Channel, Voltage-Dependent, Beta 1 Subunit 2 3
  • Calcium Channel Voltage-Dependent Subunit Beta 1 3 4
  • CACNLB1 3 4
  • CAB1 3 4
  • Dihydropyridine-Sensitive L-Type, Calcium Channel Beta-1 Subunit 3
  • Calcium Channel, L Type, Beta 1 Polypeptide 3
  • CCHLB1 3
  • CACNB1 5

External Ids for CACNB1 Gene

Previous HGNC Symbols for CACNB1 Gene

  • CACNLB1

Previous GeneCards Identifiers for CACNB1 Gene

  • GC17M036833
  • GC17M039327
  • GC17M037240
  • GC17M037704
  • GC17M034583
  • GC17M037329
  • GC17M033125

Summaries for CACNB1 Gene

Entrez Gene Summary for CACNB1 Gene

  • The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CACNB1 Gene

CACNB1 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1) is a Protein Coding gene. Diseases associated with CACNB1 include Malignant Hyperthermia and Headache. Among its related pathways are Presenilin-Mediated Signaling and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and high voltage-gated calcium channel activity. An important paralog of this gene is CACNB2.

UniProtKB/Swiss-Prot Summary for CACNB1 Gene

  • Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).

Gene Wiki entry for CACNB1 Gene

Additional gene information for CACNB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CACNB1 Gene

Genomics for CACNB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CACNB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CACNB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CACNB1

Top Transcription factor binding sites by QIAGEN in the CACNB1 gene promoter:
  • AP-1
  • c-Fos
  • c-Myb
  • LCR-F1
  • MRF-2
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • RFX1

Genomic Locations for CACNB1 Gene

Latest Assembly
chr17:39,173,453-39,197,703
(GRCh38/hg38)
Size:
24,251 bases
Orientation:
Minus strand

Previous Assembly
chr17:37,329,706-37,353,922
(GRCh37/hg19 by Entrez Gene)
Size:
24,217 bases
Orientation:
Minus strand

chr17:37,329,709-37,353,956
(GRCh37/hg19 by Ensembl)
Size:
24,248 bases
Orientation:
Minus strand

Genomic View for CACNB1 Gene

Genes around CACNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACNB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CACNB1 Gene

Proteins for CACNB1 Gene

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  • Protein details for CACNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02641-CACB1_HUMAN
    Recommended name:
    Voltage-dependent L-type calcium channel subunit beta-1
    Protein Accession:
    Q02641
    Secondary Accessions:
    • A8K114
    • O15331
    • Q02639
    • Q02640
    • Q8N3X9
    • Q9C085
    • Q9UD79

    Protein attributes for CACNB1 Gene

    Size:
    598 amino acids
    Molecular mass:
    65714 Da
    Quaternary structure:
    • Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits (By similarity). Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S (By similarity). Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. Identified in a complex with CACNA1C (PubMed:15615847). Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (By similarity). Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1 (PubMed:1309651). Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (PubMed:8107964). Interacts with JSRP1. Interacts with RYR1 (By similarity). Interacts with CBARP (By similarity).
    SequenceCaution:
    • Sequence=CAA79825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CACNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CACNB1 Gene

Protein Expression for CACNB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CACNB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CACNB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CACNB1 Gene

Domains & Families for CACNB1 Gene

Gene Families for CACNB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for CACNB1 Gene

InterPro:
Blocks:
  • L-type calcium channel beta subunit signature
  • L-type calcium channel beta-1 subunit signature

Suggested Antigen Peptide Sequences for CACNB1 Gene

GenScript: Design optimal peptide antigens:
  • Calcium channel voltage-dependent subunit beta 1 (CACB1_HUMAN)
  • Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (Q6TME4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02641

UniProtKB/Swiss-Prot:

CACB1_HUMAN :
  • Belongs to the calcium channel beta subunit family.
Family:
  • Belongs to the calcium channel beta subunit family.
genes like me logo Genes that share domains with CACNB1: view

Function for CACNB1 Gene

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Molecular function for CACNB1 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).
GENATLAS Biochemistry:
transverse tubule (TT) calcium voltage-gated channel (VDCC),L (long lasting) type,dihydropyridine (DHP) sensitive,beta 1 regulatory subunit,expressed in skeletal muscle,heart and brain isoforms,with CAG repeat

Phenotypes From GWAS Catalog for CACNB1 Gene

Gene Ontology (GO) - Molecular Function for CACNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005245 voltage-gated calcium channel activity TAS,IGI 21883149
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0008331 high voltage-gated calcium channel activity IBA 21873635
genes like me logo Genes that share ontologies with CACNB1: view
genes like me logo Genes that share phenotypes with CACNB1: view

Animal Models for CACNB1 Gene

MGI Knock Outs for CACNB1:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CACNB1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CACNB1 Gene

Localization for CACNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNB1 Gene

Cell membrane, sarcolemma. Peripheral membrane protein. Cytoplasmic side. Cell membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CACNB1 gene
Compartment Confidence
plasma membrane 4
nucleus 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CACNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005891 voltage-gated calcium channel complex TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0042383 sarcolemma IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CACNB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CACNB1 Gene

Pathways & Interactions for CACNB1 Gene

PathCards logo

SuperPathways for CACNB1 Gene

SuperPathway Contained pathways
1 DREAM Repression and Dynorphin Expression
BMP Pathway
.44
DREAM Repression and Dynorphin Expression
.44
nNOS Signaling in Skeletal Muscle
.37
Caspase Cascade
.36
Calpain Protease Regulates Cellular Mechanics
.31
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
.01
2 TCR Signaling (Qiagen)
PKC-Theta Pathway
.68
TCR Signaling
.68
ITK and TCR Signaling
.54
Fc-EpsilonRI Pathway
.49
PDGF Pathway
.39
3 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
PKA Signaling
.56
4 CCR5 Pathway in Macrophages
Androgen Signaling
.52
CCR5 Pathway in Macrophages
.52
Chemokine Signaling
.33
5 Sweet Taste Signaling
Melatonin Signaling
.72
Sweet Taste Signaling
.72
Cellular Effects of Sildenafil
.46
genes like me logo Genes that share pathways with CACNB1: view

Pathways by source for CACNB1 Gene

1 GeneGo (Thomson Reuters) pathway for CACNB1 Gene
  • Transcription CREB pathway
38 Qiagen pathways for CACNB1 Gene
  • Activation of cAMP-Dependent PKA
  • all-trans-Retinoic Acid Signaling in Brain
  • Androgen Signaling
  • BMP Pathway
  • Calpain Protease Regulates Cellular Mechanics

Gene Ontology (GO) - Biological Process for CACNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007528 neuromuscular junction development IBA 21873635
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CACNB1: view

No data available for SIGNOR curated interactions for CACNB1 Gene

Drugs & Compounds for CACNB1 Gene

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(32) Drugs for CACNB1 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ibutilide Approved Pharma Target, activator 9
Ethanol Approved Pharma Target 3544
Nimodipine Approved, Investigational Pharma Target, inhibitor Ca2+ channel blocker (L-type) 44
Verapamil Approved Pharma blocker 145
Amiodarone Approved, Investigational Pharma Target, inhibitor 141

(1) Additional Compounds for CACNB1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-Desmethylverapamil (D-702)
genes like me logo Genes that share compounds with CACNB1: view

Transcripts for CACNB1 Gene

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mRNA/cDNA for CACNB1 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CACNB1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CACNB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - - - - - - - - -
SP2: -
SP3: -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7: - - - - -
SP8: - - - -
SP9: -
SP10:

ExUns: 18a · 18b ^ 19a · 19b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CACNB1 Gene

GeneLoc Exon Structure for
CACNB1

Expression for CACNB1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CACNB1 Gene

mRNA expression in normal human tissues for CACNB1 Gene
mRNA expression by GTEx for CACNB1 GenemRNA expression by BioGPS for CACNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNB1 Gene

This gene is overexpressed in Muscle - Skeletal (x11.7).

Protein differential expression in normal tissues from HIPED for CACNB1 Gene

This gene is overexpressed in Monocytes (35.8) and Frontal cortex (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CACNB1 Gene



Protein tissue co-expression partners for CACNB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CACNB1

SOURCE GeneReport for Unigene cluster for CACNB1 Gene:

Hs.635

mRNA Expression by UniProt/SwissProt for CACNB1 Gene:

Q02641-CACB1_HUMAN
Tissue specificity: Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for CACNB1 Gene

  • Nervous system(4.8)
  • Muscle(4.7)
  • Heart(4.4)
genes like me logo Genes that share expression patterns with CACNB1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CACNB1 Gene

Orthologs for CACNB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CACNB1 29 30
  • 99.01 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CACNB1 29 30
  • 93.37 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CACNB1 29 30
  • 92.3 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cacnb1 29 16 30
  • 91.62 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CACNB1 30
  • 84 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CACNB1 30
  • 80 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CACNB1 30
  • 79 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CACNB1 30
  • 69 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii cacnb1 30
  • 70 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Ca-&bgr; 31
  • 62 (a)
Worm
(Caenorhabditis elegans)
 Secernentea ccb-1 31
  • 60 (a)
ccb-2 30
  • 29 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9266 30
  • 62 (a)
 OneToOne
Species where no ortholog for CACNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CACNB1 Gene

ENSEMBL:
Gene Tree for CACNB1 (if available)
TreeFam:
Gene Tree for CACNB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CACNB1: view image
Alliance of Genome Resources:
Additional Orthologs for CACNB1

Paralogs for CACNB1 Gene

Paralogs for CACNB1 Gene

(4) SIMAP similar genes for CACNB1 Gene using alignment to 2 proteins:

  • CACB1_HUMAN
  • Q6TME4_HUMAN
genes like me logo Genes that share paralogs with CACNB1: view

Variants for CACNB1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CACNB1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs115975977 Benign: not provided 39,175,598(-) G/A
NM_000723.5(CACNB1):c.1392C>T (p.Ser464=) 		SYNONYMOUS
rs116613643 Benign: not provided 39,175,529(-) C/T
NM_000723.5(CACNB1):c.1461G>A (p.Arg487=) 		SYNONYMOUS
rs126620591 A colorectal cancer sample p.Pro339Leu
rs1597699484 Uncertain Significance: not provided 39,184,383(-) C/A
NM_000723.5(CACNB1):c.730G>T (p.Val244Phe) 		MISSENSE
rs181552596 Likely Benign: not specified 39,184,868(-) G/T
NM_000723.5(CACNB1):c.649-4C>A 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CACNB1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CACNB1 Gene

Variant ID Type Subtype PubMed ID
esv3893012 CNV loss 25118596
nsv1134647 CNV deletion 24896259
nsv1138536 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv517435 CNV loss 19592680
nsv833440 CNV loss 17160897
nsv833441 CNV loss 17160897

Variation tolerance for CACNB1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CACNB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CACNB1
Leiden Open Variation Database (LOVD)
CACNB1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNB1 Gene

Disorders for CACNB1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CACNB1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
malignant hyperthermia
  • anesthesia related hyperthermia
headache
  • headache disorder
malignant hyperthermia susceptibility
  • malignant hyperpyrexia
multiple pterygium syndrome, escobar variant
  • evmps
arrhythmogenic right ventricular cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CACNB1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CACNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACNB1 Gene

Publications for CACNB1 Gene

  1. Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. (PMID: 8395940) Iles DE … Stewart AD (Human molecular genetics 1993) 2 3 4
  2. Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels. (PMID: 10624822) Hogan K … Powers PA (Neuroscience letters 1999) 3 4
  3. Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes. (PMID: 8905728) Fukuda K … Satoh M (Neuroscience letters 1996) 3 4
  4. Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. (PMID: 7916667) Collin T … Schwartz A (Circulation research 1993) 3 4
  5. Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping. (PMID: 8381767) Gregg RG … Hogan K (Genomics 1993) 2 3

ExternalLinks

View latest publications for CACNB1 gene in Mastermind

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