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Aliases for CACNA2D1 Gene

Aliases for CACNA2D1 Gene

  • Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1 2 3 5
  • Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 1 2 3
  • Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-1 3 4
  • CACNL2A 3 4
  • CCHL2A 3 4
  • Dihydropyridine-Sensitive L-Type, Calcium Channel Alpha-2/Delta Subunit 3
  • Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 3
  • Calcium Channel, L Type, Alpha 2 Polypeptide 3
  • Long Intergenic Non-Protein Coding RNA 1112 2
  • LncRNA-N3 3
  • LINC01112 3
  • CACNA2 3
  • MHS3 4

External Ids for CACNA2D1 Gene

Previous HGNC Symbols for CACNA2D1 Gene

  • CACNA2
  • MHS3
  • LINC01112

Previous GeneCards Identifiers for CACNA2D1 Gene

  • GC07M080114
  • GC07M081177
  • GC07M081191
  • GC07M081224
  • GC07M081417
  • GC07M081575
  • GC07M076182

Summaries for CACNA2D1 Gene

Entrez Gene Summary for CACNA2D1 Gene

  • The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]

GeneCards Summary for CACNA2D1 Gene

CACNA2D1 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1) is a Protein Coding gene. Diseases associated with CACNA2D1 include Familial Short Qt Syndrome and Brugada Syndrome. Among its related pathways are Fc-GammaR Pathway and Arrhythmogenic right ventricular cardiomyopathy (ARVC). Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and calcium channel regulator activity. An important paralog of this gene is CACNA2D2.

UniProtKB/Swiss-Prot for CACNA2D1 Gene

  • The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).

Gene Wiki entry for CACNA2D1 Gene

Additional gene information for CACNA2D1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CACNA2D1 Gene

Genomics for CACNA2D1 Gene

GeneHancer (GH) Regulatory Elements for CACNA2D1 Gene

Promoters and enhancers for CACNA2D1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J082441 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 656.5 +0.4 429 3.3 RB1 SIN3A RAD21 YY1 ZNF335 GLIS2 SCRT2 ZNF207 RCOR1 SMARCA5 CACNA2D1 GC07M082379
GH07J082410 Enhancer 0.9 VISTA ENCODE 11.7 +32.8 32769 1.5 HDGF IKZF1 NBN ZBTB33 MLLT1 IKZF2 CACNA2D1 GC07M082379
GH07J082593 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.3 -151.3 -151332 2.5 JUND PKNOX1 JUN FOS SP7 CACNA2D1 MTHFD2P5 GC07P082644
GH07J082542 Enhancer 0.7 ENCODE 11.1 -98.9 -98911 1.1 PKNOX1 FEZF1 ZFHX2 POLR2A FOS KLF13 TCF7L2 EGR2 ZEB2 ZNF843 CACNA2D1 GC07M082509 PIR36655 GC07M082589
GH07J082534 Enhancer 0.4 ENCODE 10.7 -91.1 -91114 0.2 STAT1 JUND BCL6B CACNA2D1 PIR36655 GC07M082509 GC07M082589
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CACNA2D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CACNA2D1 gene promoter:
  • POU3F2
  • USF1
  • USF-1
  • MyoD
  • FOXI1
  • HFH-3
  • Zic3
  • POU2F1

Genomic Locations for CACNA2D1 Gene

Genomic Locations for CACNA2D1 Gene
497,363 bases
Minus strand
497,355 bases
Minus strand

Genomic View for CACNA2D1 Gene

Genes around CACNA2D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CACNA2D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CACNA2D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CACNA2D1 Gene

Proteins for CACNA2D1 Gene

  • Protein details for CACNA2D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Voltage-dependent calcium channel subunit alpha-2/delta-1
    Protein Accession:
    Secondary Accessions:
    • Q17R45
    • Q9UD80
    • Q9UD81
    • Q9UD82

    Protein attributes for CACNA2D1 Gene

    1103 amino acids
    Molecular mass:
    124568 Da
    Quaternary structure:
    • Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
    • Binds gabapentin, an antiepileptic drug.

    Alternative splice isoforms for CACNA2D1 Gene


neXtProt entry for CACNA2D1 Gene

Post-translational modifications for CACNA2D1 Gene

  • Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
  • Glycosylation at posLast=998998, Asn985, posLast=895895, posLast=888888, Asn824, posLast=781781, Asn675, Asn613, posLast=604604, posLast=475475, posLast=468468, posLast=348348, Asn324, Asn184, posLast=136136, and Asn92
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CACNA2D1 Gene

Domains & Families for CACNA2D1 Gene

Gene Families for CACNA2D1 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • Belongs to the calcium channel subunit alpha-2/delta family.
  • The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • Belongs to the calcium channel subunit alpha-2/delta family.
genes like me logo Genes that share domains with CACNA2D1: view

Function for CACNA2D1 Gene

Molecular function for CACNA2D1 Gene

UniProtKB/Swiss-Prot Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
GENATLAS Biochemistry:
transverse tubule (TT) calcium voltage-gated channel (VDCC),L (long lasting) type,dihydropyridine (DHP) sensitive,alpha 2-delta regulatory subunit,(140+25kDa),skeletal muscle

Phenotypes From GWAS Catalog for CACNA2D1 Gene

Gene Ontology (GO) - Molecular Function for CACNA2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity IGI 21883149
GO:0005262 calcium channel activity IEA --
GO:0046872 metal ion binding IEA --
GO:0086007 contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential IC 17224476
GO:0086057 contributes_to voltage-gated calcium channel activity involved in bundle of His cell action potential IMP 21383000
genes like me logo Genes that share ontologies with CACNA2D1: view
genes like me logo Genes that share phenotypes with CACNA2D1: view

Human Phenotype Ontology for CACNA2D1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CACNA2D1 Gene

MGI Knock Outs for CACNA2D1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CACNA2D1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CACNA2D1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CACNA2D1 Gene

Localization for CACNA2D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CACNA2D1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CACNA2D1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CACNA2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005891 voltage-gated calcium channel complex IDA 11160515
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with CACNA2D1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CACNA2D1 Gene

Pathways & Interactions for CACNA2D1 Gene

genes like me logo Genes that share pathways with CACNA2D1: view

Gene Ontology (GO) - Biological Process for CACNA2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IDA,IEA 1309651
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051924 regulation of calcium ion transport IDA 1309651
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IMP 25527503
genes like me logo Genes that share ontologies with CACNA2D1: view

No data available for SIGNOR curated interactions for CACNA2D1 Gene

Drugs & Compounds for CACNA2D1 Gene

(19) Drugs for CACNA2D1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Felodipine Approved, Investigational Pharma Potentiation, Activator, blocker, Target, inhibitor 22
Gabapentin Approved, Investigational Pharma antagonist, Target, inhibitor GABA enhancer 332
Ibutilide Approved Pharma activator, Target 6
Isradipine Approved, Investigational Pharma Gating inhibitor, blocker, Target, inhibitor 13
Nifedipine Approved Pharma Gating inhibitor, Channel blocker, Antagonist, Pore Blocker, Agonist, Activator, blocker, Target, inhibitor 123
genes like me logo Genes that share compounds with CACNA2D1: view

Transcripts for CACNA2D1 Gene

mRNA/cDNA for CACNA2D1 Gene

(14) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CACNA2D1 Gene

Calcium channel, voltage-dependent, alpha 2/delta subunit 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CACNA2D1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CACNA2D1 Gene

No ASD Table

Relevant External Links for CACNA2D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CACNA2D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CACNA2D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CACNA2D1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.5).

Protein differential expression in normal tissues from HIPED for CACNA2D1 Gene

This gene is overexpressed in Fetal Brain (10.7), Cerebrospinal fluid (7.2), Serum (7.1), Frontal cortex (7.0), and Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CACNA2D1 Gene

Protein tissue co-expression partners for CACNA2D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CACNA2D1 Gene:


SOURCE GeneReport for Unigene cluster for CACNA2D1 Gene:


mRNA Expression by UniProt/SwissProt for CACNA2D1 Gene:

Tissue specificity: Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.

Evidence on tissue expression from TISSUES for CACNA2D1 Gene

  • Nervous system(4.5)
  • Liver(4.1)
  • Bone marrow(4)
  • Muscle(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CACNA2D1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • nervous
Head and neck:
  • brain
  • ear
  • head
  • heart
  • heart valve
  • blood
  • blood vessel
  • red blood cell
genes like me logo Genes that share expression patterns with CACNA2D1: view

Orthologs for CACNA2D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CACNA2D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CACNA2D1 34 33
  • 99.76 (n)
(Bos Taurus)
Mammalia CACNA2D1 34 33
  • 93.74 (n)
(Canis familiaris)
Mammalia CACNA2D1 34 33
  • 92.81 (n)
(Mus musculus)
Mammalia Cacna2d1 16 34 33
  • 90.04 (n)
(Rattus norvegicus)
Mammalia Cacna2d1 33
  • 89.6 (n)
(Monodelphis domestica)
Mammalia CACNA2D1 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia CACNA2D1 34
  • 87 (a)
(Gallus gallus)
Aves CACNA2D1 34 33
  • 78.12 (n)
(Anolis carolinensis)
Reptilia CACNA2D1 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cacna2d1 33
  • 74.2 (n)
(Danio rerio)
Actinopterygii CACNA2D1 (3 of 3) 34
  • 70 (a)
cacna2d1a 34 33
  • 64.41 (n)
CACNA2D1 (2 of 3) 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS07108.2 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea unc-36 35
  • 23 (a)
tag-180 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for CACNA2D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CACNA2D1 Gene

Gene Tree for CACNA2D1 (if available)
Gene Tree for CACNA2D1 (if available)
Evolutionary constrained regions (ECRs) for CACNA2D1: view image

Paralogs for CACNA2D1 Gene

Paralogs for CACNA2D1 Gene

(4) SIMAP similar genes for CACNA2D1 Gene using alignment to 8 proteins:

  • B7Z658_HUMAN
  • H0Y715_HUMAN
  • O95026_HUMAN
genes like me logo Genes that share paralogs with CACNA2D1: view

Variants for CACNA2D1 Gene

Sequence variations from dbSNP and Humsavar for CACNA2D1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1060503151 uncertain-significance, Brugada syndrome 82,038,146(-) A/T coding_sequence_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs112176710 benign, Brugada syndrome 81,962,030(-) T/C genic_downstream_transcript_variant, intron_variant
rs1229502 benign, not specified, Cardiovascular phenotype 81,959,320(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs142553634 likely-benign, benign, Cardiovascular phenotype, Brugada syndrome 81,964,261(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs146250893 uncertain-significance, Cardiovascular phenotype 81,950,450(-) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CACNA2D1 Gene

Variant ID Type Subtype PubMed ID
dgv3603n106 CNV deletion 24896259
dgv6516n100 CNV gain 25217958
esv1009997 CNV deletion 20482838
esv1010444 CNV gain 20482838
esv1301171 CNV deletion 17803354
esv2214231 CNV deletion 18987734
esv2655042 CNV insertion 19546169
esv2657789 CNV deletion 23128226
esv2672825 CNV deletion 23128226
esv2674222 CNV deletion 23128226
esv2676782 CNV deletion 23128226
esv2734746 CNV deletion 23290073
esv2734747 CNV deletion 23290073
esv2734748 CNV deletion 23290073
esv2752186 CNV gain 17911159
esv2762682 CNV loss 21179565
esv28876 CNV loss 19812545
esv29327 CNV gain 19812545
esv3306374 CNV mobile element insertion 20981092
esv3357660 CNV insertion 20981092
esv3394814 CNV insertion 20981092
esv3541998 CNV deletion 23714750
esv3542001 CNV deletion 23714750
esv3571943 CNV loss 25503493
esv3571944 CNV loss 25503493
esv3613895 CNV loss 21293372
esv3613898 CNV loss 21293372
esv3613900 CNV loss 21293372
esv3613901 CNV loss 21293372
esv3613902 CNV loss 21293372
esv3613903 CNV gain 21293372
esv3613905 CNV loss 21293372
esv3613907 CNV loss 21293372
esv3613908 CNV loss 21293372
esv3891154 CNV gain 25118596
esv3891155 CNV loss 25118596
esv3891156 CNV loss 25118596
esv4702 CNV loss 18987735
nsv1019753 CNV gain 25217958
nsv1024460 CNV gain 25217958
nsv1026154 CNV gain 25217958
nsv1030172 CNV loss 25217958
nsv1033925 CNV loss 25217958
nsv1074528 CNV deletion 25765185
nsv1075040 CNV deletion 25765185
nsv1124237 CNV deletion 24896259
nsv1128347 CNV deletion 24896259
nsv1133663 CNV deletion 24896259
nsv1145151 CNV deletion 24896259
nsv464610 CNV loss 19166990
nsv464611 CNV loss 19166990
nsv464612 CNV loss 19166990
nsv473681 CNV novel sequence insertion 20440878
nsv510094 OTHER sequence alteration 20534489
nsv518794 CNV gain 19592680
nsv522458 CNV gain 19592680
nsv523665 CNV loss 19592680
nsv524315 CNV gain 19592680
nsv5815 CNV insertion 18451855
nsv5816 CNV deletion 18451855
nsv607694 CNV loss 21841781
nsv607695 CNV loss 21841781
nsv607696 CNV loss 21841781
nsv607697 CNV loss 21841781
nsv607698 CNV loss 21841781
nsv607699 CNV loss 21841781
nsv607700 CNV gain 21841781
nsv818528 CNV loss 17921354
nsv818529 CNV loss 17921354
nsv824184 CNV loss 20364138
nsv951367 CNV duplication 24416366
nsv955988 CNV deletion 24416366
nsv957571 CNV deletion 24416366

Variation tolerance for CACNA2D1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CACNA2D1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CACNA2D1 Gene

Disorders for CACNA2D1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CACNA2D1 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
familial short qt syndrome
  • sqts
brugada syndrome
  • right bundle branch block, st segment elevation, and sudden death syndrome
short qt syndrome
  • sqts
timothy syndrome
  • ts
malignant hyperthermia
  • hyperpyrexia, malignant
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CACNA2D1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CACNA2D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CACNA2D1 Gene

Publications for CACNA2D1 Gene

  1. Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit. (PMID: 22054663) Calderón-Rivera A … Felix R (Cell calcium 2012) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N … Nonalcoholic Steatohepatitis Clinical Research Network (Gastroenterology 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58

Products for CACNA2D1 Gene

Sources for CACNA2D1 Gene

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