Aliases for CACNA1B Gene
- Calcium Voltage-Gated Channel Subunit Alpha1 B 2 3 5
- Calcium Channel, Voltage-Dependent, N Type, Alpha 1B Subunit 2 3
- Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1B 3 4
- Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 3 4
- Brain Calcium Channel III 3 4
- CACNL1A5 3 4
- BIII 3 4
- Calcium Channel, Voltage-Dependent, L Type, Alpha 1B Subunit 3
- Calcium Channel, L Type, Alpha-1 Polypeptide Isoform 5 4
External Ids for CACNA1B Gene
Previous HGNC Symbols for CACNA1B Gene
Previous GeneCards Identifiers for CACNA1B Gene
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CACNA1B Gene
CACNA1B (Calcium Voltage-Gated Channel Subunit Alpha1 B) is a Protein Coding gene. Diseases associated with CACNA1B include Neurodevelopmental Disorder With Seizures And Nonepileptic Hyperkinetic Movements and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ion channel activity. An important paralog of this gene is CACNA1A.
UniProtKB/Swiss-Prot Summary for CACNA1B Gene
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.