To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding whe... See more...

Aliases for CABYR Gene

Aliases for CABYR Gene

  • Calcium Binding Tyrosine Phosphorylation Regulated 2 3 5
  • Cancer/Testis Antigen 88 2 3 4
  • Calcium-Binding Tyrosine Phosphorylation-Regulated Protein 3 4
  • Testis-Specific Calcium-Binding Protein CBP86 3 4
  • Calcium-Binding Protein 86 3 4
  • Fibrousheathin II 3 4
  • Fibrousheathin-2 3 4
  • CBP86 3 4
  • FSP-2 3 4
  • CT88 3 4
  • FSP2 3 4
  • Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated (Fibrousheathin 2) 3
  • Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated 2
  • Testis Tissue Sperm-Binding Protein Li 84P 3
  • Fibrousheathin 2 2
  • CABYRc/D 3
  • CABYRa 3
  • CABYRc 3
  • CABYRe 3

External Ids for CABYR Gene

Previous GeneCards Identifiers for CABYR Gene

  • GC18P021611
  • GC18P021450
  • GC18P019970
  • GC18P019972
  • GC18P021718
  • GC18P018575

Summaries for CABYR Gene

Entrez Gene Summary for CABYR Gene

  • To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for CABYR Gene

CABYR (Calcium Binding Tyrosine Phosphorylation Regulated) is a Protein Coding gene. Diseases associated with CABYR include Suppurative Thyroiditis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and enzyme binding.

UniProtKB/Swiss-Prot Summary for CABYR Gene

  • May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

Gene Wiki entry for CABYR Gene

Additional gene information for CABYR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CABYR Gene

Genomics for CABYR Gene

GeneHancer (GH) Regulatory Elements for CABYR Gene

Promoters and enhancers for CABYR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J024138 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 761.9 +0.1 144 2.2 NFYC RELA POLR2A SP1 ZBED1 GLIS2 CREB1 PKNOX1 ZIC2 TCF7L2 CABYR HSALNG0120488 piR-33422-185
GH18J024136 Enhancer 0.6 ENCODE 762.2 -1.9 -1855 1.1 FOXA1 SP1 NFE2L2 FOXA2 POLR2A NFE2 JUND RUNX3 USF1 FOS CABYR ENSG00000279332 HSALNG0120488
GH18J024114 Enhancer 0.7 Ensembl 22.2 -23.3 -23255 1.4 FOXA1 ATF1 CREB1 SP1 CEBPG ZNF384 CEBPA RXRA SOX13 GATAD2A CABYR RNU6-435P ENSG00000264924 ENSG00000265204 NONHSAG023555.2 TTC39C
GH18J023991 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.7 -145.5 -145491 3.7 ZNF24 ETV6 HLF RAD21 BCL6B POLR2A SP1 SP7 ZSCAN21 CREM TTC39C LAMA3 TTC39C-AS1 CABYR ANKRD29 RPL23AP77 NONHSAG023555.2
GH18J023582 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.6 -553.9 -553916 5.9 CTCF SREBF1 ZBTB6 SMARCE1 RBPJ POLR2A NR2F1 NR2F6 CREB1 HCFC1 NPC1 RMC1 ANKRD29 CABLES1 TMEM241 CABYR ENSG00000199366 lnc-RMC1-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CABYR on UCSC Golden Path with GeneCards custom track

Genomic Locations for CABYR Gene

Genomic Locations for CABYR Gene
chr18:24,138,956-24,161,603
(GRCh38/hg38)
Size:
22,648 bases
Orientation:
Plus strand
chr18:21,718,942-21,741,567
(GRCh37/hg19)
Size:
22,626 bases
Orientation:
Plus strand

Genomic View for CABYR Gene

Genes around CABYR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CABYR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CABYR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CABYR Gene

Proteins for CABYR Gene

  • Protein details for CABYR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75952-CABYR_HUMAN
    Recommended name:
    Calcium-binding tyrosine phosphorylation-regulated protein
    Protein Accession:
    O75952
    Secondary Accessions:
    • B2R857
    • Q8WXW5
    • Q9HAY3
    • Q9HAY4
    • Q9HAY5
    • Q9HCY9

    Protein attributes for CABYR Gene

    Size:
    493 amino acids
    Molecular mass:
    52774 Da
    Quaternary structure:
    • Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.

    Alternative splice isoforms for CABYR Gene

neXtProt entry for CABYR Gene

Post-translational modifications for CABYR Gene

  • Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CABYR Gene

Domains & Families for CABYR Gene

Gene Families for CABYR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CABYR Gene

Suggested Antigen Peptide Sequences for CABYR Gene

GenScript: Design optimal peptide antigens:
  • Testis-specific calcium-binding protein CBP86 (CABYR_HUMAN)
genes like me logo Genes that share domains with CABYR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CABYR Gene

Function for CABYR Gene

Molecular function for CABYR Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

Phenotypes From GWAS Catalog for CABYR Gene

Gene Ontology (GO) - Molecular Function for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,IDA 11820818
GO:0017124 SH3 domain binding NAS 11820818
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity ISS 20731842
genes like me logo Genes that share ontologies with CABYR: view
genes like me logo Genes that share phenotypes with CABYR: view

Animal Model Products

CRISPR Products

miRNA for CABYR Gene

miRTarBase miRNAs that target CABYR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CABYR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CABYR Gene

Localization for CABYR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CABYR Gene

Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Isoform 5: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CABYR gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
extracellular 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 11820818
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CABYR: view

Pathways & Interactions for CABYR Gene

PathCards logo

SuperPathways for CABYR Gene

No Data Available

SIGNOR curated interactions for CABYR Gene

Other effect:

Gene Ontology (GO) - Biological Process for CABYR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement NAS 18421703
GO:0048240 sperm capacitation IEA,NAS 11820818
genes like me logo Genes that share ontologies with CABYR: view

No data available for Pathways by source for CABYR Gene

Drugs & Compounds for CABYR Gene

(1) Drugs for CABYR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
genes like me logo Genes that share compounds with CABYR: view

Transcripts for CABYR Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CABYR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CABYR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - -

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CABYR Gene

GeneLoc Exon Structure for
CABYR
ECgene alternative splicing isoforms for
CABYR

Expression for CABYR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CABYR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CABYR Gene

This gene is overexpressed in Testis (x36.0).

Protein differential expression in normal tissues from HIPED for CABYR Gene

This gene is overexpressed in Testis (42.4) and Ovary (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CABYR Gene



Protein tissue co-expression partners for CABYR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CABYR Gene:

CABYR

SOURCE GeneReport for Unigene cluster for CABYR Gene:

Hs.511983

mRNA Expression by UniProt/SwissProt for CABYR Gene:

O75952-CABYR_HUMAN
Tissue specificity: Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.

Evidence on tissue expression from TISSUES for CABYR Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CABYR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CABYR Gene

Orthologs for CABYR Gene

This gene was present in the common ancestor of chordates.

Orthologs for CABYR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CABYR 33 32
  • 99.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CABYR 33 32
  • 82.16 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cabyr 32
  • 79.06 (n)
mouse
(Mus musculus)
Mammalia Cabyr 17 33 32
  • 78.65 (n)
cow
(Bos Taurus)
Mammalia CABYR 33 32
  • 77.08 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CABYR 33
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CABYR 33
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CABYR 33
  • 49 (a)
OneToOne
Species where no ortholog for CABYR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CABYR Gene

ENSEMBL:
Gene Tree for CABYR (if available)
TreeFam:
Gene Tree for CABYR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CABYR: view image

Paralogs for CABYR Gene

Pseudogenes.org Pseudogenes for CABYR Gene

genes like me logo Genes that share paralogs with CABYR: view

No data available for Paralogs for CABYR Gene

Variants for CABYR Gene

Sequence variations from dbSNP and Humsavar for CABYR Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000114657 -- 24,142,287(+) C/G intron_variant
rs1000231151 -- 24,142,112(+) G/T intron_variant
rs1000339603 -- 24,148,777(+) G/A intron_variant
rs1000556993 -- 24,140,481(+) T/C intron_variant
rs1000639743 -- 24,147,796(+) C/G intron_variant

Variation tolerance for CABYR Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CABYR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CABYR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CABYR Gene

Disorders for CABYR Gene

MalaCards: The human disease database

(1) MalaCards diseases for CABYR Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards
Search CABYR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CABYR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CABYR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CABYR Gene

Publications for CABYR Gene

  1. Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. (PMID: 16139264) Kim YH … Herr JC (Developmental biology 2005) 2 3 4 23 56
  2. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. (PMID: 11820818) Naaby-Hansen S … Herr JC (Developmental biology 2002) 2 3 4 23 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. CABYR is a novel cancer-testis antigen in lung cancer. (PMID: 17317841) Luo C … He D (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 2 3 56
  5. Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain. (PMID: 15752768) Hsu HC … Hong YR (Biochemical and biophysical research communications 2005) 3 4 56

Products for CABYR Gene

Sources for CABYR Gene