Aliases for CABYR Gene
External Ids for CABYR Gene
Previous GeneCards Identifiers for CABYR Gene
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for CABYR Gene
CABYR (Calcium Binding Tyrosine Phosphorylation Regulated) is a Protein Coding gene. Diseases associated with CABYR include Suppurative Thyroiditis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and enzyme binding.
UniProtKB/Swiss-Prot for CABYR Gene
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.