Aliases for CABLES1 Gene
External Ids for CABLES1 Gene
Previous GeneCards Identifiers for CABLES1 Gene
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for CABLES1 Gene
CABLES1 (Cdk5 And Abl Enzyme Substrate 1) is a Protein Coding gene. Diseases associated with CABLES1 include Endometrial Hyperplasia. Among its related pathways are Guidance Cues and Growth Cone Motility and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CABLES2.
UniProtKB/Swiss-Prot Summary for CABLES1 Gene
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).