Aliases for CABIN1 Gene
External Ids for CABIN1 Gene
Previous GeneCards Identifiers for CABIN1 Gene
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
GeneCards Summary for CABIN1 Gene
CABIN1 (Calcineurin Binding Protein 1) is a Protein Coding gene. Diseases associated with CABIN1 include Complication After Organ Transplantation and Thrombotic Thrombocytopenic Purpura. Among its related pathways are Nur77 Signaling in T-Cell and Role of Calcineurin-dependent NFAT signaling in lymphocytes. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity.
UniProtKB/Swiss-Prot Summary for CABIN1 Gene
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.