Aliases for CAB39L Gene

Aliases for CAB39L Gene

  • Calcium Binding Protein 39 Like 2 3 5
  • Calcium-Binding Protein 39-Like 3 4
  • Mo25-Like Protein 3 4
  • Antigen MLAA-34 3 4
  • BA103J18.3 2 3
  • MO25beta 3 4
  • MO2L 2 3
  • Calcium Binding Protein 39-Like 2
  • Sarcoma Antigen NY-SAR-79 3
  • U937-Associated Antigen 3
  • MO25-BETA 3
  • FLJ12577 2
  • CAB39L 5

External Ids for CAB39L Gene

Previous GeneCards Identifiers for CAB39L Gene

  • GC13M047682
  • GC13M048781
  • GC13M049882
  • GC13M030678

Summaries for CAB39L Gene

GeneCards Summary for CAB39L Gene

CAB39L (Calcium Binding Protein 39 Like) is a Protein Coding gene. Diseases associated with CAB39L include Monocytic Leukemia and Leukemia, Acute Monocytic. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is CAB39.

UniProtKB/Swiss-Prot Summary for CAB39L Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Gene Wiki entry for CAB39L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAB39L Gene

Genomics for CAB39L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAB39L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAB39L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAB39L

Top Transcription factor binding sites by QIAGEN in the CAB39L gene promoter:
  • aMEF-2
  • C/EBPalpha
  • E4BP4
  • FOXD1
  • HNF-1
  • HNF-1A
  • MEF-2A
  • POU2F1
  • POU2F1a
  • POU2F1b

Genomic Locations for CAB39L Gene

Latest Assembly
136,202 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
135,415 bases
Minus strand

(GRCh37/hg19 by Ensembl)
135,477 bases
Minus strand

Genomic View for CAB39L Gene

Genes around CAB39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39L Gene

Proteins for CAB39L Gene

  • Protein details for CAB39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-binding protein 39-like
    Protein Accession:
    Secondary Accessions:
    • Q5TAW6
    • Q6WG71
    • Q96FG1
    • Q9BZ33

    Protein attributes for CAB39L Gene

    337 amino acids
    Molecular mass:
    39088 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.
    • Sequence=BAB14147.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    • Found in serum of 50% of patients with acute monocytic leukemia.

    Three dimensional structures from OCA and Proteopedia for CAB39L Gene

neXtProt entry for CAB39L Gene

Post-translational modifications for CAB39L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for CAB39L
  • Boster Bio Antibodies for CAB39L
  • Santa Cruz Biotechnology (SCBT) Antibodies for CAB39L

No data available for DME Specific Peptides for CAB39L Gene

Domains & Families for CAB39L Gene

Gene Families for CAB39L Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAB39L Gene

  • Mo25-like

Suggested Antigen Peptide Sequences for CAB39L Gene

GenScript: Design optimal peptide antigens:
  • Mo25-like protein (CB39L_HUMAN)
  • Calcium binding protein 39-like (Q5TAW7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Mo25 family.
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39L: view

Function for CAB39L Gene

Molecular function for CAB39L Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Phenotypes From GWAS Catalog for CAB39L Gene

Gene Ontology (GO) - Molecular Function for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043539 protein serine/threonine kinase activator activity IBA 21873635
genes like me logo Genes that share ontologies with CAB39L: view
genes like me logo Genes that share phenotypes with CAB39L: view

Animal Models for CAB39L Gene

MGI Knock Outs for CAB39L:
  • Cab39l Cab39l<tm1b(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAB39L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAB39L Gene

Localization for CAB39L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAB39L gene
Compartment Confidence
cytosol 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAB39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAB39L Gene

Pathways & Interactions for CAB39L Gene

genes like me logo Genes that share pathways with CAB39L: view

Pathways by source for CAB39L Gene

Gene Ontology (GO) - Biological Process for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0035556 intracellular signal transduction IBA 21873635
GO:0071902 positive regulation of protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with CAB39L: view

No data available for SIGNOR curated interactions for CAB39L Gene

Drugs & Compounds for CAB39L Gene

No Compound Related Data Available

Transcripts for CAB39L Gene

mRNA/cDNA for CAB39L Gene

15 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAB39L

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39L Gene

No ASD Table

Relevant External Links for CAB39L Gene

GeneLoc Exon Structure for

Expression for CAB39L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAB39L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAB39L Gene

This gene is overexpressed in Cardia (17.3) and Colon muscle (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAB39L Gene

Protein tissue co-expression partners for CAB39L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAB39L

SOURCE GeneReport for Unigene cluster for CAB39L Gene:


Evidence on tissue expression from TISSUES for CAB39L Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with CAB39L: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAB39L Gene

Orthologs for CAB39L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAB39L 29 30
  • 99.8 (n)
(Monodelphis domestica)
Mammalia CAB39L 30
  • 96 (a)
(Bos Taurus)
Mammalia CAB39L 29 30
  • 91.02 (n)
(Canis familiaris)
Mammalia CAB39L 29 30
  • 90.6 (n)
(Mus musculus)
Mammalia Cab39l 29 16 30
  • 90.5 (n)
(Rattus norvegicus)
Mammalia Cab39l 29
  • 89.91 (n)
(Ornithorhynchus anatinus)
Mammalia CAB39L 30
  • 63 (a)
(Gallus gallus)
Aves CAB39L 29 30
  • 83.99 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cab39l 29
  • 78.44 (n)
Str.15219 29
African clawed frog
(Xenopus laevis)
Amphibia MGC68674 29
(Danio rerio)
Actinopterygii cab39l 29 30
  • 74.47 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Mo25 30
  • 64 (a)
(Caenorhabditis elegans)
Secernentea mop-25.2 30
  • 56 (a)
mop-25.1 30
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 30
  • 28 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G18940 29
  • 52.54 (n)
(Oryza sativa)
Liliopsida Os03g0359700 29
  • 51.04 (n)
(Zea mays)
Liliopsida Zm.3116 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3108 30
  • 63 (a)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmo25 29
  • 54.26 (n)
Species where no ortholog for CAB39L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAB39L Gene

Gene Tree for CAB39L (if available)
Gene Tree for CAB39L (if available)
Evolutionary constrained regions (ECRs) for CAB39L: view image
Alliance of Genome Resources:
Additional Orthologs for CAB39L

Paralogs for CAB39L Gene

Paralogs for CAB39L Gene

(2) SIMAP similar genes for CAB39L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CAB39L: view

Variants for CAB39L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CAB39L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CAB39L Gene

Variant ID Type Subtype PubMed ID
dgv969n106 CNV deletion 24896259
esv1939259 CNV deletion 18987734
esv2273400 CNV deletion 18987734
esv2539030 CNV deletion 19546169
esv2675887 CNV deletion 23128226
esv2747391 CNV deletion 23290073
esv2747392 CNV deletion 23290073
esv2747393 CNV deletion 23290073
esv3304012 CNV mobile element insertion 20981092
esv3339499 CNV insertion 20981092
esv3377952 CNV insertion 20981092
esv3404428 CNV insertion 20981092
esv3449183 CNV duplication 20981092
esv3550444 CNV deletion 23714750
esv3580632 CNV loss 25503493
esv3632044 CNV loss 21293372
esv3632046 CNV loss 21293372
esv4504 CNV loss 18987735
esv989296 CNV deletion 20482838
esv997002 CNV deletion 20482838
nsv1037 CNV deletion 18451855
nsv1069752 CNV deletion 25765185
nsv1149895 CNV deletion 26484159
nsv435647 CNV deletion 17901297
nsv512316 CNV loss 21212237
nsv523648 CNV gain 19592680
nsv561613 CNV loss 21841781
nsv64662 CNV deletion 16902084
nsv832607 CNV loss 17160897
nsv957462 CNV deletion 24416366

Variation tolerance for CAB39L Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAB39L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAB39L Gene

Disorders for CAB39L Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAB39L Gene - From: COP and GCD

Disorder Aliases PubMed IDs
monocytic leukemia
  • monocytic leukaemia
leukemia, acute monocytic
  • acute monocytic leukemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CAB39L

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CAB39L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAB39L Gene

Publications for CAB39L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (PMID: 18592235) Zhang PY … Li WB (Cancer immunology, immunotherapy : CII 2009) 3 22
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4

Products for CAB39L Gene

Sources for CAB39L Gene