Aliases for CAB39 Gene

Aliases for CAB39 Gene

  • Calcium Binding Protein 39 2 3 5
  • MO25 2 3 4
  • Calcium-Binding Protein 39 3 4
  • MO25alpha 3 4
  • CGI-66 2 3
  • Protein Mo25 4
  • CAB39 5

External Ids for CAB39 Gene

Previous GeneCards Identifiers for CAB39 Gene

  • GC00U916965
  • GC02P231403
  • GC02P231285
  • GC02P231577
  • GC02P223417

Summaries for CAB39 Gene

GeneCards Summary for CAB39 Gene

CAB39 (Calcium Binding Protein 39) is a Protein Coding gene. Diseases associated with CAB39 include Non-Invasive Bladder Urothelial Carcinoma. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and kinase binding. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot Summary for CAB39 Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Wiki entry for CAB39 Gene

Additional gene information for CAB39 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAB39 Gene

Genomics for CAB39 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CAB39 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAB39 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAB39

Top Transcription factor binding sites by QIAGEN in the CAB39 gene promoter:
  • FAC1
  • Pax-2
  • Pax-2a
  • S8
  • TBP

Genomic Locations for CAB39 Gene

Genomic Locations for CAB39 Gene
chr2:230,712,842-230,821,075
(GRCh38/hg38)
Size:
108,234 bases
Orientation:
Plus strand
chr2:231,577,557-231,685,790
(GRCh37/hg19)
Size:
108,234 bases
Orientation:
Plus strand

Genomic View for CAB39 Gene

Genes around CAB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39 Gene

Proteins for CAB39 Gene

  • Protein details for CAB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y376-CAB39_HUMAN
    Recommended name:
    Calcium-binding protein 39
    Protein Accession:
    Q9Y376
    Secondary Accessions:
    • A8K8L7

    Protein attributes for CAB39 Gene

    Size:
    341 amino acids
    Molecular mass:
    39869 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for CAB39 Gene

neXtProt entry for CAB39 Gene

Post-translational modifications for CAB39 Gene

  • Ubiquitination at Lys301
  • Modification sites at PhosphoSitePlus

Other Protein References for CAB39 Gene

No data available for DME Specific Peptides for CAB39 Gene

Domains & Families for CAB39 Gene

Gene Families for CAB39 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAB39 Gene

InterPro:
Blocks:
  • Mo25-like
ProtoNet:

Suggested Antigen Peptide Sequences for CAB39 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ96790, Homo sapiens MO25 protein (MO25), mRNA (A8K8L7_HUMAN)
  • Protein Mo25 (CAB39_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y376

UniProtKB/Swiss-Prot:

CAB39_HUMAN :
  • Belongs to the Mo25 family.
Family:
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39: view

Function for CAB39 Gene

Molecular function for CAB39 Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Phenotypes From GWAS Catalog for CAB39 Gene

Gene Ontology (GO) - Molecular Function for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA,IEA --
GO:0005515 protein binding IPI 14676191
GO:0019900 kinase binding IPI 19892943
GO:0030295 protein kinase activator activity IDA 19892943
GO:0043539 protein serine/threonine kinase activator activity IDA 19892943
genes like me logo Genes that share ontologies with CAB39: view
genes like me logo Genes that share phenotypes with CAB39: view

Animal Model Products

CRISPR Products

miRNA for CAB39 Gene

miRTarBase miRNAs that target CAB39

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAB39

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAB39 Gene

Localization for CAB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAB39 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAB39 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with CAB39: view

Pathways & Interactions for CAB39 Gene

genes like me logo Genes that share pathways with CAB39: view

Pathways by source for CAB39 Gene

1 R&D Systems pathway for CAB39 Gene
1 Qiagen pathway for CAB39 Gene
  • AMPK Enzyme Complex Pathway
1 Cell Signaling Technology pathway for CAB39 Gene

Gene Ontology (GO) - Biological Process for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007050 cell cycle arrest TAS --
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 24393035
GO:0014823 response to activity IEA --
GO:0018105 peptidyl-serine phosphorylation IDA 24393035
genes like me logo Genes that share ontologies with CAB39: view

No data available for SIGNOR curated interactions for CAB39 Gene

Drugs & Compounds for CAB39 Gene

No Compound Related Data Available

Transcripts for CAB39 Gene

mRNA/cDNA for CAB39 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAB39

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39 Gene

No ASD Table

Relevant External Links for CAB39 Gene

GeneLoc Exon Structure for
CAB39

Expression for CAB39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAB39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAB39 Gene

This gene is overexpressed in Urine (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAB39 Gene



Protein tissue co-expression partners for CAB39 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAB39

SOURCE GeneReport for Unigene cluster for CAB39 Gene:

Hs.603930

Evidence on tissue expression from TISSUES for CAB39 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Intestine(4.5)
  • Kidney(3.4)
  • Muscle(2.9)
  • Heart(2.8)
  • Lung(2.7)
  • Blood(2.7)
  • Skin(2.4)
  • Thyroid gland(2.3)
  • Stomach(2.2)
  • Spleen(2.2)
  • Pancreas(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CAB39: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAB39 Gene

Orthologs for CAB39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39 Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia CAB39 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CAB39 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia CAB39 30 31
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CAB39 30 31
  • 94.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CAB39 30 31
  • 94.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cab39 30 17 31
  • 92.47 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CAB39 30 31
  • 88.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CAB39 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486569 30
  • 80.45 (n)
Zebrafish
(Danio rerio)
Actinopterygii cab39 30 31
  • 79.57 (n)
OneToOne
Dr.9072 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000812 30
  • 64.46 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Mo25 30 31
  • 63.84 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mop-25.1 30 31
  • 61.68 (n)
ManyToMany
mop-25.2 31
  • 59 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 31 33
  • 30 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G17270 30
  • 52.38 (n)
Soybean
(Glycine max)
eudicotyledons Gma.4699 30
Rice
(Oryza sativa)
Liliopsida Os07g0585100 30
  • 54.02 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3108 31
  • 67 (a)
OneToMany
Species where no ortholog for CAB39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CAB39 Gene

ENSEMBL:
Gene Tree for CAB39 (if available)
TreeFam:
Gene Tree for CAB39 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAB39: view image

Paralogs for CAB39 Gene

Paralogs for CAB39 Gene

(1) SIMAP similar genes for CAB39 Gene using alignment to 1 proteins:

  • CAB39_HUMAN

Pseudogenes.org Pseudogenes for CAB39 Gene

genes like me logo Genes that share paralogs with CAB39: view

Variants for CAB39 Gene

Additional dbSNP identifiers (rs#s) for CAB39 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAB39 Gene

Variant ID Type Subtype PubMed ID
esv2671712 CNV deletion 23128226
esv2674961 CNV deletion 23128226
esv2760618 CNV loss 21179565
esv3594611 CNV loss 21293372
esv3594612 CNV loss 21293372
esv3594613 CNV loss 21293372
nsv584675 CNV loss 21841781
nsv834565 CNV gain 17160897
nsv953197 CNV duplication 24416366
nsv961569 CNV duplication 23825009

Variation tolerance for CAB39 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAB39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAB39

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAB39 Gene

Disorders for CAB39 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAB39 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-invasive bladder urothelial carcinoma
  • stage 0 bladder urothelial carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CAB39 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CAB39: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAB39 Gene

Publications for CAB39 Gene

  1. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PMID: 19892943) Zeqiraj E … van Aalten DM (Science (New York, N.Y.) 2009) 3 4
  2. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PMID: 19513107) Zeqiraj E … van Aalten DM (PLoS biology 2009) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano JM … Alessi DR (The EMBO journal 2004) 3 23
  5. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. (PMID: 14730349) Milburn CC … van Aalten DM (Nature structural & molecular biology 2004) 3 4

Products for CAB39 Gene

Sources for CAB39 Gene