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Aliases for CAAP1 Gene

Aliases for CAAP1 Gene

  • Caspase Activity And Apoptosis Inhibitor 1 2 3 3 5
  • Conserved Anti-Apoptotic Protein 2 3 4
  • C9orf82 3 4
  • CAAP 3 4
  • Chromosome 9 Open Reading Frame 82 2

External Ids for CAAP1 Gene

Previous HGNC Symbols for CAAP1 Gene

  • C9orf82

Summaries for CAAP1 Gene

GeneCards Summary for CAAP1 Gene

CAAP1 (Caspase Activity And Apoptosis Inhibitor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CAAP1 Gene

  • Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.

Gene Wiki entry for CAAP1 Gene

Additional gene information for CAAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAAP1 Gene

Genomics for CAAP1 Gene

GeneHancer (GH) Regulatory Elements for CAAP1 Gene

Promoters and enhancers for CAAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J026889 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.9 909 3.8 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 GC09P026892 CAAP1 IFT74 LRRC19 PLAA ENSG00000232466
GH09J026894 Enhancer 0.2 ENCODE 650.7 -1.4 -1350 0.2 RN7SL100P GC09P026892 CAAP1 IFT74 PLAA IFT74-AS1
GH09J026945 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 27.4 -54.0 -54005 3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 IFT74 PLAA CAAP1 RN7SL100P
GH09J026953 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 27.1 -62.9 -62941 3.9 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF207 IFT74 IFT74-AS1 CAAP1 LRRC19 PLAA
GH09J026949 Enhancer 0.7 ENCODE 27.6 -57.2 -57186 1.1 NFIB JUN RFX5 GTF3C2 GATA3 POLR3A ZNF366 POLR2A FOS CHD2 CAAP1 IFT74 LRRC19 PLAA IFT74-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAAP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CAAP1 Gene

Genomic Locations for CAAP1 Gene
chr9:26,840,685-26,892,828
(GRCh38/hg38)
Size:
52,144 bases
Orientation:
Minus strand
chr9:26,840,683-26,892,826
(GRCh37/hg19)
Size:
52,144 bases
Orientation:
Minus strand

Genomic View for CAAP1 Gene

Genes around CAAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAAP1 Gene

Proteins for CAAP1 Gene

  • Protein details for CAAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8G2-CAAP1_HUMAN
    Recommended name:
    Caspase activity and apoptosis inhibitor 1
    Protein Accession:
    Q9H8G2
    Secondary Accessions:
    • B4DWT4
    • D3DRK4
    • Q5VY32
    • Q6IPE6
    • Q96C59

    Protein attributes for CAAP1 Gene

    Size:
    361 amino acids
    Molecular mass:
    38368 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAAP1 Gene

Post-translational modifications for CAAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAAP1 Gene

No data available for DME Specific Peptides for CAAP1 Gene

Domains & Families for CAAP1 Gene

Gene Families for CAAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAAP1: view

No data available for UniProtKB/Swiss-Prot for CAAP1 Gene

Function for CAAP1 Gene

Molecular function for CAAP1 Gene

UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.

Phenotypes From GWAS Catalog for CAAP1 Gene

genes like me logo Genes that share phenotypes with CAAP1: view

Animal Model Products

CRISPR Products

miRNA for CAAP1 Gene

miRTarBase miRNAs that target CAAP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAAP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAAP1 Gene

Localization for CAAP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAAP1 gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CAAP1 Gene

Pathways & Interactions for CAAP1 Gene

SuperPathways for CAAP1 Gene

No Data Available

Interacting Proteins for CAAP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369431%0d%0a9606.ENSP00000358622%0d%0a9606.ENSP00000261600%0d%0a
Selected Interacting proteins: ENSP00000369431 Q9H8G2-CAAP1_HUMAN for CAAP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CAAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CAAP1: view

No data available for Pathways by source and SIGNOR curated interactions for CAAP1 Gene

Drugs & Compounds for CAAP1 Gene

No Compound Related Data Available

Transcripts for CAAP1 Gene

mRNA/cDNA for CAAP1 Gene

Unigene Clusters for CAAP1 Gene

Caspase activity and apoptosis inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAAP1

Alternative Splicing Database (ASD) splice patterns (SP) for CAAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3: -

Relevant External Links for CAAP1 Gene

GeneLoc Exon Structure for
CAAP1
ECgene alternative splicing isoforms for
CAAP1

Expression for CAAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAAP1 Gene

Protein differential expression in normal tissues from HIPED for CAAP1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAAP1 Gene



Protein tissue co-expression partners for CAAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAAP1 Gene:

CAAP1

SOURCE GeneReport for Unigene cluster for CAAP1 Gene:

Hs.178357

mRNA Expression by UniProt/SwissProt for CAAP1 Gene:

Q9H8G2-CAAP1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAAP1 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CAAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAAP1 Gene

Orthologs for CAAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAAP1 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CAAP1 34 33
  • 92.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CAAP1 34 33
  • 88.37 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Caap1 33
  • 87.61 (n)
mouse
(Mus musculus)
Mammalia Caap1 16 34 33
  • 82.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CAAP1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAAP1 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF82 33
  • 75.49 (n)
CAAP1 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAAP1 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia caap1 33
  • 66.25 (n)
Str.10787 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6753 33
zebrafish
(Danio rerio)
Actinopterygii LOC100329847 33
  • 62.09 (n)
FP236812.4 34
  • 46 (a)
OneToOne
Species where no ortholog for CAAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAAP1 Gene

ENSEMBL:
Gene Tree for CAAP1 (if available)
TreeFam:
Gene Tree for CAAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAAP1: view image

Paralogs for CAAP1 Gene

No data available for Paralogs for CAAP1 Gene

Variants for CAAP1 Gene

Sequence variations from dbSNP and Humsavar for CAAP1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000009285 -- 26,892,005(-) A/T intron_variant
rs1000020392 -- 26,850,467(-) C/G intron_variant
rs1000040166 -- 26,861,410(-) T/G intron_variant
rs1000117647 -- 26,884,895(-) G/C intron_variant
rs1000138460 -- 26,867,077(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CAAP1 Gene

Variant ID Type Subtype PubMed ID
esv3620120 CNV loss 21293372
esv3891647 CNV gain 25118596
nsv1015259 CNV gain 25217958
nsv1026827 CNV gain 25217958
nsv982204 CNV duplication 23825009

Variation tolerance for CAAP1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAAP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAAP1 Gene

Disorders for CAAP1 Gene

Additional Disease Information for CAAP1

No disorders were found for CAAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAAP1 Gene

Publications for CAAP1 Gene

  1. Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. (PMID: 21980415) Zhang Y … Anderson MW (PloS one 2011) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CAAP1 Gene

Sources for CAAP1 Gene

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