Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue di... See more...

Aliases for CA9 Gene

Aliases for CA9 Gene

  • Carbonic Anhydrase 9 2 3 4 5
  • Carbonic Anhydrase IX 2 3 4
  • CAIX 2 3 4
  • MN 2 3 4
  • Renal Cell Carcinoma-Associated Antigen G250 3 4
  • RCC-Associated Protein G250 2 3
  • RCC-Associated Antigen G250 3 4
  • Carbonate Dehydratase IX 3 4
  • Carbonic Dehydratase 2 3
  • Membrane Antigen MN 3 4
  • P54/58N 3 4
  • CA-IX 3 4
  • PMW1 3 4
  • EC 4.2.1.1 4
  • G250 4
  • CA9 5

External Ids for CA9 Gene

Previous GeneCards Identifiers for CA9 Gene

  • GC09P035986
  • GC09P035843
  • GC09P035663
  • GC09P035629

Summaries for CA9 Gene

Entrez Gene Summary for CA9 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]

GeneCards Summary for CA9 Gene

CA9 (Carbonic Anhydrase 9) is a Protein Coding gene. Diseases associated with CA9 include Sarcomatoid Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma. Among its related pathways are Metabolism and Celecoxib Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot Summary for CA9 Gene

  • Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.

Tocris Summary for CA9 Gene

  • Carbonic anhydrases (EC 4.2.1.1) are zinc-containing enzymes belonging to the lyases family, and are primarily responsible for catalyzing the reversible hydration of carbon dioxide to form bicarbonate (HCO3-) and hydrogen (H+) ions.

Gene Wiki entry for CA9 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CA9 Gene

Genomics for CA9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CA9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J035672 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 260 +1.0 985 3.9 ZMYM3 POLR2A MAX FOXA2 SAP130 DMAP1 YY1 FOSL2 TAF1 ZFP36 CA9 ARHGEF39 CCDC107 RF00017-6953 RF00017-6952
GH09J035726 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +56.6 56606 8.6 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 SIX5 ZNF592 ATF2 TLN1 CREB3 HSALNG0070946 TPM2 TMEM8B ARHGEF39 GBA2 CCDC107 PIGO RN7SL22P
GH09J035616 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.2 -54.6 -54555 6.4 BCLAF1 JUND POLR2A ZIC2 BCL11A ETS1 SIN3A GABPA RFX5 EBF1 CD72 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B CREB3 TLN1 GBA2
GH09J035656 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7 -12.8 -12793 10 BCLAF1 SP1 ZNF654 ZNF207 MYC ZNF600 IKZF1 SSRP1 ZNF580 ZNF592 ARHGEF39 CCDC107 HSALNG0070936 lnc-SIT1-1 CA9 TPM2 CD72 TLN1 MN298576 RMRP
GH09J035634 Enhancer 0.9 ENCODE dbSUPER 16.3 -36.6 -36575 6.1 IKZF1 TRIM22 TBP NR2C1 BHLHE40 EGR1 BMI1 NFATC1 HDGF NR2F1 lnc-CCDC107-3 ARHGEF39 CA9 CCDC107 CD72 RN7SL22P GBA2 RGP1 MSMP ENSG00000228843
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CA9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CA9

Top Transcription factor binding sites by QIAGEN in the CA9 gene promoter:
  • LCR-F1
  • Nkx2-5
  • p300
  • PPAR-alpha
  • Sp1
  • Tal-1beta

Genomic Locations for CA9 Gene

Latest Assembly
chr9:35,673,809-35,681,159
(GRCh38/hg38)
Size:
7,351 bases
Orientation:
Plus strand

Previous Assembly
chr9:35,673,925-35,681,156
(GRCh37/hg19 by Entrez Gene)
Size:
7,232 bases
Orientation:
Plus strand

chr9:35,673,853-35,681,156
(GRCh37/hg19 by Ensembl)
Size:
7,304 bases
Orientation:
Plus strand

Genomic View for CA9 Gene

Genes around CA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA9 Gene

Proteins for CA9 Gene

  • Protein details for CA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16790-CAH9_HUMAN
    Recommended name:
    Carbonic anhydrase 9
    Protein Accession:
    Q16790
    Secondary Accessions:
    • Q5T4R1

    Protein attributes for CA9 Gene

    Size:
    459 amino acids
    Molecular mass:
    49698 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Forms oligomers linked by disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for CA9 Gene

neXtProt entry for CA9 Gene

Post-translational modifications for CA9 Gene

  • Asn-346 bears high-mannose type glycan structures.
  • Glycosylation at Thr115 and Asn346
  • Modification sites at PhosphoSitePlus

Other Protein References for CA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for CA9

No data available for DME Specific Peptides for CA9 Gene

Domains & Families for CA9 Gene

Gene Families for CA9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CA9 Gene

InterPro:
Blocks:
  • Carbonic anhydrase, eukaryotic

Suggested Antigen Peptide Sequences for CA9 Gene

GenScript: Design optimal peptide antigens:
  • pMW1 (CAH9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16790

UniProtKB/Swiss-Prot:

CAH9_HUMAN :
  • Belongs to the alpha-carbonic anhydrase family.
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA9: view

Function for CA9 Gene

Molecular function for CA9 Gene

UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1;.
UniProtKB/Swiss-Prot Induction:
By hypoxia.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:19805286};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
GENATLAS Biochemistry:
carbonic anhydrase 9,MN/CA antigen expressed in Hela cells and some human carcinomas

Enzyme Numbers (IUBMB) for CA9 Gene

Phenotypes From GWAS Catalog for CA9 Gene

Gene Ontology (GO) - Molecular Function for CA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 26871637
GO:0008270 zinc ion binding IEA --
GO:0016829 lyase activity IEA --
GO:0016836 hydro-lyase activity IBA 21873635
genes like me logo Genes that share ontologies with CA9: view
genes like me logo Genes that share phenotypes with CA9: view

Animal Models for CA9 Gene

MGI Knock Outs for CA9:

miRNA for CA9 Gene

miRTarBase miRNAs that target CA9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CA9 Gene

Localization for CA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA9 Gene

Nucleus. Nucleus, nucleolus. Cell membrane. Single-pass type I membrane protein. Cell projection, microvillus membrane. Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA9 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 3
mitochondrion 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with CA9: view

Pathways & Interactions for CA9 Gene

genes like me logo Genes that share pathways with CA9: view

SIGNOR curated interactions for CA9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002009 morphogenesis of an epithelium IEA --
GO:0006730 one-carbon metabolic process IBA 21873635
GO:0015701 bicarbonate transport TAS --
GO:0033574 response to testosterone IEA --
genes like me logo Genes that share ontologies with CA9: view

Drugs & Compounds for CA9 Gene

(34) Drugs for CA9 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzthiazide Approved Pharma Target, Target, inhibitor 0
Hydroflumethiazide Approved, Investigational, Withdrawn Pharma Target, inhibitor 1
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 78
Brinzolamide Approved Pharma CA II inhibitor 70
Dichlorphenamide Approved, Investigational Pharma 2

(13) Additional Compounds for CA9 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen carbonate
  • [CO(OH)2]
  • Dihydrogen carbonate
  • H2CO3
  • Koehlensaeure
  • Dihydrogen carbonic acid
71-52-3
S4
1330061-67-0

(2) Tocris Compounds for CA9 Gene

Compound Action Cas Number
S4 High affinity and selective CA IX and CA XII inhibitor 1330061-67-0
U 104 Potent carbonic anhydrase (CA) IX and XII inhibitor 178606-66-1

(7) ApexBio Compounds for CA9 Gene

Compound Action Cas Number
Brinzolamide CA II inhibitor 138890-62-7
Chlorothiazide Carbonic anhydrase inhibitor 58-94-6
Dichlorphenamide 120-97-8
Dorzolamide HCl Carbonic anhydrase inhibitor 130693-82-2
Methazolamide Carbonic anhydrase inhibitor 554-57-4
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
U-104 CAIX inhibitor 178606-66-1
genes like me logo Genes that share compounds with CA9: view

Drug products for research

Transcripts for CA9 Gene

mRNA/cDNA for CA9 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA9

Alternative Splicing Database (ASD) splice patterns (SP) for CA9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: -
SP4: -

Relevant External Links for CA9 Gene

GeneLoc Exon Structure for
CA9

Expression for CA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CA9 Gene

mRNA differential expression in normal tissues according to GTEx for CA9 Gene

This gene is overexpressed in Stomach (x37.6).

Protein differential expression in normal tissues from HIPED for CA9 Gene

This gene is overexpressed in Stomach (44.6) and Gallbladder (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CA9 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CA9

SOURCE GeneReport for Unigene cluster for CA9 Gene:

Hs.63287

mRNA Expression by UniProt/SwissProt for CA9 Gene:

Q16790-CAH9_HUMAN
Tissue specificity: Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.

Evidence on tissue expression from TISSUES for CA9 Gene

  • Intestine(4.6)
  • Stomach(3.9)
  • Gall bladder(2.9)
  • Skin(2.6)
  • Liver(2.6)
  • Kidney(2.3)
  • Blood(2.3)
  • Pancreas(2.1)
  • Nervous system(2.1)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CA9: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CA9 Gene

Orthologs for CA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CA9 29 30
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CA9 29 30
  • 85.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CA9 29 30
  • 84.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Car9 29
  • 80.69 (n)
Mouse
(Mus musculus)
Mammalia Car9 29 16 30
  • 79.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CA9 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CA9 29 30
  • 55.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CA9 30
  • 57 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ca9 29 30
  • 48.08 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013402 29
  • 48.4 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6074 31
  • 34 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8628 30
  • 17 (a)
OneToMany
Species where no ortholog for CA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CA9 Gene

ENSEMBL:
Gene Tree for CA9 (if available)
TreeFam:
Gene Tree for CA9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CA9: view image
Alliance of Genome Resources:
Additional Orthologs for CA9

Paralogs for CA9 Gene

Paralogs for CA9 Gene

(5) SIMAP similar genes for CA9 Gene using alignment to 1 proteins:

  • CAH9_HUMAN
genes like me logo Genes that share paralogs with CA9: view

Variants for CA9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CA9 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs181213293 Benign: not provided 35,674,301(+) T/C
NM_001216.3(CA9):c.342T>C (p.Pro114=)
SYNONYMOUS
rs2071676 -- p.Val33Met
rs3829078 -- p.Gln326Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CA9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CA9 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv466385 CNV loss 19166990
nsv614166 CNV loss 21841781
nsv6528 CNV insertion 18451855

Variation tolerance for CA9 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.33; 92.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CA9
Leiden Open Variation Database (LOVD)
CA9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA9 Gene

Disorders for CA9 Gene

MalaCards: The human disease database

(26) MalaCards diseases for CA9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
sarcomatoid renal cell carcinoma
  • renal cell carcinoma, spindle cell
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
hypoxia
oncocytoma
  • oxyphilic adenoma
adenocarcinoma in situ
- elite association - COSMIC cancer census association via MalaCards
Search CA9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CA9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA9 Gene

Publications for CA9 Gene

  1. CA9 gene: single nucleotide polymorphism predicts metastatic renal cell carcinoma prognosis. (PMID: 19539328) de Martino M … Belldegrun AS (The Journal of urology 2009) 3 22 40
  2. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. (PMID: 8084592) Pastorek J … Stanbridge EJ (Oncogene 1994) 3 4 22
  3. Carbonic anhydrase IX expression in prostate cancer. (PMID: 20038959) Smyth LG … Watson RW (Prostate cancer and prostatic diseases 2010) 3 22
  4. High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer. (PMID: 20461082) Ilie M … Hofman P (British journal of cancer 2010) 3 22
  5. The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. (PMID: 20398423) Nordfors K … Haapasalo H (BMC cancer 2010) 3 22

Products for CA9 Gene

Sources for CA9 Gene