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Aliases for CA6 Gene

Aliases for CA6 Gene

  • Carbonic Anhydrase 6 2 3 3 5
  • Salivary Carbonic Anhydrase 3 4
  • Secreted Carbonic Anhydrase 3 4
  • Carbonate Dehydratase VI 3 4
  • Carbonic Anhydrase VI 2 4
  • CA-VI 3 4
  • Carbonic Anhydrase VI Nirs Variant 2 3
  • EC 4
  • GUSTIN 3

External Ids for CA6 Gene

Previous GeneCards Identifiers for CA6 Gene

  • GC01P008626
  • GC01P008816
  • GC01P008715
  • GC01P008940
  • GC01P008928
  • GC01P008155

Summaries for CA6 Gene

Entrez Gene Summary for CA6 Gene

  • The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA6 Gene

CA6 (Carbonic Anhydrase 6) is a Protein Coding gene. Diseases associated with CA6 include Multilocular Clear Cell Renal Cell Carcinoma and Dental Caries. Among its related pathways are Metabolism and Nitrogen metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA12.

UniProtKB/Swiss-Prot for CA6 Gene

  • Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Gene Wiki entry for CA6 Gene

Additional gene information for CA6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA6 Gene

Genomics for CA6 Gene

GeneHancer (GH) Regulatory Elements for CA6 Gene

Promoters and enhancers for CA6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J008945 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 650.7 +0.8 823 2.5 ELF3 TFAP4 SAP130 ARID4B ERF ZBTB40 GATAD1 NR2F6 HOMEZ THAP11 CA6 RN7SL451P GC01M008979
GH01J008944 Enhancer 0.4 ENCODE 650.7 -1.8 -1834 0.1 MZF1 ZBTB20 CA6 ENSG00000232663
GH01J008941 Enhancer 0.8 Ensembl ENCODE 12.9 -3.7 -3651 1.1 SOX5 SOX13 FOXA2 JUN FOSL1 ZFHX2 JUND ATF7 ZNF600 FOS CA6 ENSG00000232663
GH01J008993 Enhancer 0.6 ENCODE 13.2 +48.5 48506 2 CTCF SKI ZNF280A ZNF766 TRIM24 EGR2 FOXP1 ZNF18 TRIM28 CA6 SLC2A7 RNU6-304P MIR34A LZIC RN7SL451P GC01M008979
GH01J008911 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 0.3 -34.2 -34229 0.9 ELF3 FOXA2 ARID4B RAD21 ZSCAN9 RARA SLC30A9 ZNF614 MIXL1 KLF11 ENSG00000232663 CA6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CA6 gene promoter:
  • c-Myb
  • AML1a
  • MEF-2A
  • aMEF-2
  • FOXO1
  • FOXO1a
  • JunD
  • JunB
  • Fra-1
  • FosB

Genomic Locations for CA6 Gene

Genomic Locations for CA6 Gene
29,308 bases
Plus strand
29,230 bases
Plus strand

Genomic View for CA6 Gene

Genes around CA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA6 Gene

Proteins for CA6 Gene

  • Protein details for CA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 6
    Protein Accession:
    Secondary Accessions:
    • E7EMQ1
    • Q5FBW3
    • Q5FC00
    • Q96QX8
    • Q9UF03

    Protein attributes for CA6 Gene

    308 amino acids
    Molecular mass:
    35367 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA6 Gene

    Alternative splice isoforms for CA6 Gene


neXtProt entry for CA6 Gene

Post-translational modifications for CA6 Gene

  • Glycosylation at posLast=256256 and posLast=6767

Antibody Products

  • R&D Systems Antibodies for CA6 (Carbonic Anhydrase VI)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CA6

No data available for DME Specific Peptides for CA6 Gene

Domains & Families for CA6 Gene

Gene Families for CA6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CA6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA6: view

Function for CA6 Gene

Molecular function for CA6 Gene

UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide. Its role in saliva is unknown.
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
GENATLAS Biochemistry:
carbonic anhydrase VI,secretory granules,parotid and submaxillar glands

Enzyme Numbers (IUBMB) for CA6 Gene

Phenotypes From GWAS Catalog for CA6 Gene

Gene Ontology (GO) - Molecular Function for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS --
GO:0005515 protein binding IPI --
GO:0008270 zinc ion binding IEA --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CA6: view
genes like me logo Genes that share phenotypes with CA6: view

Animal Models for CA6 Gene

MGI Knock Outs for CA6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CA6 Gene

Localization for CA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA6 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 24248522
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with CA6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CA6 Gene

Pathways & Interactions for CA6 Gene

genes like me logo Genes that share pathways with CA6: view

Pathways by source for CA6 Gene

2 Reactome pathways for CA6 Gene
1 KEGG pathway for CA6 Gene

Gene Ontology (GO) - Biological Process for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with CA6: view

No data available for SIGNOR curated interactions for CA6 Gene

Drugs & Compounds for CA6 Gene

(8) Drugs for CA6 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 69
Zinc Approved, Investigational Pharma 2430
Mafenide Approved, Vet_approved Pharma Target, antagonist 5
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for CA6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbonic acid
  • [co(OH)2]
  • Dihydrogen carbonate
  • H2CO3
  • Koehlensaeure
  • Carbonate
genes like me logo Genes that share compounds with CA6: view

Transcripts for CA6 Gene

Unigene Clusters for CA6 Gene

Carbonic anhydrase VI:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA6

Alternative Splicing Database (ASD) splice patterns (SP) for CA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for CA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x31.7) and Skin - Not Sun Exposed (Suprapubic) (x18.9).

Protein differential expression in normal tissues from HIPED for CA6 Gene

This gene is overexpressed in Skin (41.9), Saliva (15.6), and Salivary gland (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA6 Gene

Protein tissue co-expression partners for CA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CA6 Gene:


SOURCE GeneReport for Unigene cluster for CA6 Gene:


mRNA Expression by UniProt/SwissProt for CA6 Gene:

Tissue specificity: Major constituent of saliva.

Evidence on tissue expression from TISSUES for CA6 Gene

  • Saliva(2.9)
genes like me logo Genes that share expression patterns with CA6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CA6 Gene

Orthologs for CA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CA6 34 33
  • 98.46 (n)
(Canis familiaris)
Mammalia CA6 34 33
  • 80.28 (n)
(Bos Taurus)
Mammalia CA6 34 33
  • 78.59 (n)
(Rattus norvegicus)
Mammalia Car6 33
  • 70.16 (n)
(Mus musculus)
Mammalia Car6 16 34 33
  • 67.79 (n)
(Ornithorhynchus anatinus)
Mammalia CA6 34
  • 51 (a)
(Monodelphis domestica)
Mammalia CA6 34
  • 39 (a)
(Gallus gallus)
Aves CA6 34 33
  • 61.23 (n)
(Danio rerio)
Actinopterygii LOC100006448 33
  • 60.5 (n)
ca6 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8628 34
  • 16 (a)
Species where no ortholog for CA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA6 Gene

Gene Tree for CA6 (if available)
Gene Tree for CA6 (if available)
Evolutionary constrained regions (ECRs) for CA6: view image

Paralogs for CA6 Gene

Paralogs for CA6 Gene

(11) SIMAP similar genes for CA6 Gene using alignment to 4 proteins:

  • F8W148_HUMAN
  • Q8N4G4_HUMAN
genes like me logo Genes that share paralogs with CA6: view

Variants for CA6 Gene

Sequence variations from dbSNP and Humsavar for CA6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000049368 -- 8,973,268(+) C/T intron_variant
rs1000082108 -- 8,956,902(+) C/T intron_variant
rs1000176600 -- 8,972,208(+) C/T intron_variant
rs1000271047 -- 8,963,128(+) G/A intron_variant
rs1000305566 -- 8,951,310(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CA6 Gene

Variant ID Type Subtype PubMed ID
esv2762130 CNV loss 21179565
esv2763506 CNV gain 21179565
esv3585160 CNV loss 21293372
esv3890637 CNV gain 25118596
nsv1965 CNV insertion 18451855
nsv471857 CNV novel sequence insertion 20440878
nsv516097 CNV loss 19592680
nsv545345 CNV gain 21841781

Variation tolerance for CA6 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.16; 97.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CA6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA6 Gene

Disorders for CA6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CA6 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
multilocular clear cell renal cell carcinoma
  • cystadenocarcinoma of kidney
dental caries
  • dental caries extending into pulp
  • vesicular pharyngitis
tricuspid valve stenosis
  • tricuspid stenosis
denture stomatitis
  • denture sore mouth
- elite association - COSMIC cancer census association via MalaCards
Search CA6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CA6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA6 Gene

Publications for CA6 Gene

  1. Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7-9 years. (PMID: 19721466) Peres RC … Line SR (The pharmacogenomics journal 2010) 3 22 44 58
  2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White PS … Brodeur GM (Cytogenetics and cell genetics 1998) 2 3 22 58
  3. Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry. (PMID: 1899030) Aldred P … Fernley RT (Biochemistry 1991) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for CA6 Gene

Sources for CA6 Gene

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