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The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
CA6 (Carbonic Anhydrase 6) is a Protein Coding gene. Diseases associated with CA6 include Dental Caries and Sulfonamide Allergy. Among its related pathways are Metabolism and Nitrogen metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004089 | carbonate dehydratase activity | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016829 | lyase activity | IEA | -- |
GO:0016836 | hydro-lyase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IDA | 24248522 |
GO:0070062 | extracellular exosome | HDA | 19199708 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
|
|
2 | Nitrogen metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 24248522 |
GO:0006730 | one-carbon metabolic process | IEA,IBA | 21873635 |
GO:0015701 | bicarbonate transport | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Zonisamide | Approved, Investigational | Pharma | Target, inhibitor | Antiepileptic with anticonvulsant and mechanistic effect | 74 | |
Zinc | Approved, Investigational | Pharma | 1594 | |||
Benzthiazide | Approved | Pharma | Target, inhibitor | 0 | ||
Cyclothiazide | Approved | Pharma | Allosteric regulator, Positive, Target, inhibitor | 0 | ||
Mafenide | Approved, Vet_approved | Pharma | Target, antagonist | 6 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Carbonic acid |
|
71-52-3, 463-79-6 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||
SP4: | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CA6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CA6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CA6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Car6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Car6 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CA6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CA6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CA6 30 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC100006448 30 |
|
||
ca6 31 |
|
OneToOne | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8628 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762130 | CNV | loss | 21179565 |
esv2763506 | CNV | gain | 21179565 |
esv3585160 | CNV | loss | 21293372 |
esv3890637 | CNV | gain | 25118596 |
nsv1965 | CNV | insertion | 18451855 |
nsv471857 | CNV | novel sequence insertion | 20440878 |
nsv516097 | CNV | loss | 19592680 |
nsv545345 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dental caries |
|
|
sulfonamide allergy |
|
|
hand, foot and mouth disease |
|
|
enamel erosion |
|
|
multilocular clear cell renal cell carcinoma |
|
|