Aliases for CA5B Gene
External Ids for CA5B Gene
Previous GeneCards Identifiers for CA5B Gene
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes carbonic anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A carbonic anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq, Jan 2019]
GeneCards Summary for CA5B Gene
CA5B (Carbonic Anhydrase 5B) is a Protein Coding gene. Diseases associated with CA5B include Second-Degree Atrioventricular Block and Mobitz Type Ii Atrioventricular Block. Among its related pathways are Metabolism and Nitrogen metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA5A.
UniProtKB/Swiss-Prot Summary for CA5B Gene
Reversible hydration of carbon dioxide.