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Aliases for CA14 Gene

Aliases for CA14 Gene

  • Carbonic Anhydrase 14 2 3 3 5
  • Carbonic Anhydrase XIV 2 3 4
  • Carbonate Dehydratase XIV 3 4
  • CA-XIV 3 4
  • Carbonic Dehydratase 3
  • EC 4
  • CAXiV 3

External Ids for CA14 Gene

Previous GeneCards Identifiers for CA14 Gene

  • GC01P147881
  • GC01P145972
  • GC01P147005
  • GC01P147446
  • GC01P147043
  • GC01P148488
  • GC01P150230
  • GC01P121608

Summaries for CA14 Gene

Entrez Gene Summary for CA14 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA14 Gene

CA14 (Carbonic Anhydrase 14) is a Protein Coding gene. Among its related pathways are Metabolism and Nitrogen metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA12.

UniProtKB/Swiss-Prot for CA14 Gene

  • Reversible hydration of carbon dioxide.

Gene Wiki entry for CA14 Gene

Additional gene information for CA14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA14 Gene

Genomics for CA14 Gene

GeneHancer (GH) Regulatory Elements for CA14 Gene

Promoters and enhancers for CA14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J150254 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654.1 +0.7 715 5.8 HDGF FOXA2 ARNT ARID4B SIN3A YY1 ZNF143 DEK SP3 SP5 CA14 ENSG00000276110 MRPS21 ADAMTSL4 ECM1 C1orf54
GH01J150008 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.2 -247.0 -246951 2.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 OTUD7B PRPF3 SETDB1 ARNT MTMR11 ADAMTSL4 SV2A UBE2D3P3 RPRD2 CTSK
GH01J150065 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.5 -190.2 -190196 3.8 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A LOC105371427 VPS45 GC01M150063 OTUD7B PRPF3 SETDB1 ARNT SF3B4 UBE2D3P3 HIST2H2AB
GH01J150156 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -95.2 -95227 10.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B YBX1 IRF4 POLR2B ZNF766 LOC105371433 PLEKHO1 SV2A MTMR11 CA14 MCL1 PRPF3 MRPS21 ANP32E RPRD2
GH01J150213 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.5 -43.3 -43318 1.5 PKNOX1 CLOCK SIN3A YY1 ELK1 ZNF207 ZNF143 RUNX3 RXRA NFYC GC01P150215 GC01P150214 SETDB1 SF3B4 ANP32E PIP5K1A PRPF3 RNU2-17P ARNT HIST2H2AB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CA14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CA14 gene promoter:
  • AREB6
  • Arnt
  • AhR
  • C/EBPbeta
  • Bach2
  • GATA-2
  • RORalpha1
  • RREB-1
  • ZIC2

Genomic Locations for CA14 Gene

Genomic Locations for CA14 Gene
7,920 bases
Plus strand
7,925 bases
Plus strand

Genomic View for CA14 Gene

Genes around CA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA14 Gene

Proteins for CA14 Gene

  • Protein details for CA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 14
    Protein Accession:
    Secondary Accessions:
    • Q5TB24
    • Q8NCF4

    Protein attributes for CA14 Gene

    337 amino acids
    Molecular mass:
    37668 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA14 Gene

neXtProt entry for CA14 Gene

Post-translational modifications for CA14 Gene

  • Glycosylation at posLast=213213
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CA14 (Carbonic Anhydrase XIV/CA14)

No data available for DME Specific Peptides for CA14 Gene

Domains & Families for CA14 Gene

Gene Families for CA14 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CA14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA14: view

Function for CA14 Gene

Molecular function for CA14 Gene

UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide.
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.9 mM for CO(2) {ECO:0000269 PubMed:18618712};
GENATLAS Biochemistry:
carbonic anhydrase XIV,expressed in adult heart,brain,kidney,liver and skeletal muscle,highly homolog to CA12

Enzyme Numbers (IUBMB) for CA14 Gene

Phenotypes From GWAS Catalog for CA14 Gene

Gene Ontology (GO) - Molecular Function for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CA14: view
genes like me logo Genes that share phenotypes with CA14: view

Animal Models for CA14 Gene

MGI Knock Outs for CA14:

Animal Model Products

CRISPR Products

miRNA for CA14 Gene

miRTarBase miRNAs that target CA14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA14

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CA14 Gene

Localization for CA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA14 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA14 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with CA14: view

Pathways & Interactions for CA14 Gene

genes like me logo Genes that share pathways with CA14: view

Pathways by source for CA14 Gene

2 Reactome pathways for CA14 Gene
1 KEGG pathway for CA14 Gene

Gene Ontology (GO) - Biological Process for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with CA14: view

No data available for SIGNOR curated interactions for CA14 Gene

Drugs & Compounds for CA14 Gene

(10) Drugs for CA14 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetazolamide Approved, Vet_approved Pharma inhibitor, Target 86
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 69
Brinzolamide Approved Pharma inhibitor CA II inhibitor 63
Chlorthalidone Approved Pharma blocker 66
Dorzolamide Approved Pharma inhibitor 70

(3) Additional Compounds for CA14 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbonic acid
  • [co(OH)2]
  • Dihydrogen carbonate
  • H2CO3
  • Koehlensaeure
  • Carbonate
genes like me logo Genes that share compounds with CA14: view

Transcripts for CA14 Gene

Unigene Clusters for CA14 Gene

Carbonic anhydrase XIV:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA14

Alternative Splicing Database (ASD) splice patterns (SP) for CA14 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP2: -
SP3: -

Relevant External Links for CA14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA14 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.5) and Brain - Substantia nigra (x5.6).

Protein differential expression in normal tissues from HIPED for CA14 Gene

This gene is overexpressed in Retina (46.3) and Seminal vesicle (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CA14 Gene:


SOURCE GeneReport for Unigene cluster for CA14 Gene:


mRNA Expression by UniProt/SwissProt for CA14 Gene:

Tissue specificity: High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.

Evidence on tissue expression from TISSUES for CA14 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CA14: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CA14 Gene

Orthologs for CA14 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CA14 34 33
  • 99.01 (n)
(Bos Taurus)
Mammalia CA14 34 33
  • 89.32 (n)
(Canis familiaris)
Mammalia CA14 34 33
  • 87.7 (n)
(Rattus norvegicus)
Mammalia Car14 33
  • 85.06 (n)
(Mus musculus)
Mammalia Car14 16 34 33
  • 84.77 (n)
(Monodelphis domestica)
Mammalia CA14 34
  • 74 (a)
(Gallus gallus)
Aves CA14 34 33
  • 59.04 (n)
(Anolis carolinensis)
Reptilia CA14 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca14 33
  • 58.12 (n)
(Danio rerio)
Actinopterygii ca14 34 33
  • 56.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6074 35
  • 33 (a)
CG6906 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8628 34
  • 18 (a)
Species where no ortholog for CA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA14 Gene

Gene Tree for CA14 (if available)
Gene Tree for CA14 (if available)
Evolutionary constrained regions (ECRs) for CA14: view image

Paralogs for CA14 Gene

Paralogs for CA14 Gene

(14) SIMAP similar genes for CA14 Gene using alignment to 4 proteins:

  • A8K3J4_HUMAN
  • U3KQH0_HUMAN Pseudogenes for CA14 Gene

genes like me logo Genes that share paralogs with CA14: view

Variants for CA14 Gene

Sequence variations from dbSNP and Humsavar for CA14 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000706090 -- 150,259,575(+) G/A intron_variant
rs1003159906 -- 150,256,889(+) C/T upstream_transcript_variant
rs1003435907 -- 150,257,145(+) C/T upstream_transcript_variant
rs1004595135 -- 150,259,991(+) T/A intron_variant
rs1005606054 -- 150,258,302(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CA14 Gene

Variant ID Type Subtype PubMed ID
nsv1009508 CNV loss 25217958
nsv1011223 CNV gain 25217958

Variation tolerance for CA14 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CA14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA14 Gene

Disorders for CA14 Gene

Additional Disease Information for CA14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CA14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA14 Gene

Publications for CA14 Gene

  1. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. (PMID: 10512682) Fujikawa-Adachi K … Onishi S (Genomics 1999) 2 3 4 22 58
  2. The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. (PMID: 24374484) Alterio V … De Simone G (Biopolymers 2014) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CA14 Gene

Sources for CA14 Gene

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