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Aliases for CA11 Gene

Aliases for CA11 Gene

  • Carbonic Anhydrase 11 2 3 5
  • Carbonic Anhydrase-Related Protein 2 2 3 4
  • Carbonic Anhydrase-Related Protein 11 3 4
  • Carbonic Anhydrase-Related Protein XI 2 3
  • Carbonic Anhydrase XI 2 3
  • CA-RP XI 2 4
  • CA-RP II 3 4
  • CARP-2 3 4
  • CA-XI 3 4
  • CARP XI 4
  • CARPX1 3
  • CA-RP 3
  • CARP2 4

External Ids for CA11 Gene

Previous GeneCards Identifiers for CA11 Gene

  • GC19M049785
  • GC19M049509
  • GC19M053817
  • GC19M053833
  • GC19M049141
  • GC19M045520

Summaries for CA11 Gene

Entrez Gene Summary for CA11 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA11 Gene

CA11 (Carbonic Anhydrase 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA10.

UniProtKB/Swiss-Prot for CA11 Gene

Gene Wiki entry for CA11 Gene

Additional gene information for CA11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA11 Gene

Genomics for CA11 Gene

GeneHancer (GH) Regulatory Elements for CA11 Gene

Promoters and enhancers for CA11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048644 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.4 393 3.2 SP1 CC2D1A CTCF SIX5 ZNF148 MLLT1 ZSCAN21 CDC5L BACH1 MCM2 CA11 GRWD1 SNORD35A NOP53-AS1 ALDH16A1 SNORD35B PRR12 NOP53 RPS11 SNRNP70
GH19J048958 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.7 -317.8 -317835 10.2 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 SIX5 ZNF148 NKRF POLR2A FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PRR12 PTOV1-AS2 GRWD1 PIH1D1 IRF3
GH19J047741 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.7 +902.1 902090 5.4 SP1 ZFX CTCF ELF3 MNT SIX5 ZNF148 NKRF POLR2A MLLT1 NOP53 ZC3H4 BICRA SELENOW GRWD1 RASIP1 CA11 ENSG00000268093 ZSWIM9 NOP53-AS1
GH19J049579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.7 -934.4 -934406 3.2 SP1 ZFX ELF3 ZKSCAN8 SIX5 NKRF POLR2A CEBPG GTF2F1 CSDE1 PRRG2 NOSIP PRR12 NUP62 POLD1 SNRNP70 PTOV1-AS2 PIH1D1 ENSG00000268047 SNORD35A
GH19J048328 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +314.5 314508 5.8 HDGF SP1 CC2D1A SIX5 CBFA2T2 ZNF148 NKRF MLLT1 GTF2F1 ZNF687 BICRA SNRNP70 GRWD1 TMEM143 NOP53-AS1 CYTH2 CA11 NOP53 KDELR1 RPL18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CA11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CA11 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • Nkx2-5

Genomic Locations for CA11 Gene

Genomic Locations for CA11 Gene
8,249 bases
Minus strand
8,371 bases
Minus strand

Genomic View for CA11 Gene

Genes around CA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA11 Gene

Proteins for CA11 Gene

  • Protein details for CA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase-related protein 11
    Protein Accession:
    Secondary Accessions:
    • O60596
    • Q6FHI1
    • Q9UEC4

    Protein attributes for CA11 Gene

    328 amino acids
    Molecular mass:
    36238 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CA11 Gene

Post-translational modifications for CA11 Gene

  • Glycosylation at posLast=118118, isoforms=170, and isoforms=260
  • Modification sites at PhosphoSitePlus

Other Protein References for CA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CA11 Gene

Domains & Families for CA11 Gene

Gene Families for CA11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CA11 Gene

Suggested Antigen Peptide Sequences for CA11 Gene

GenScript: Design optimal peptide antigens:
  • Carbonic anhydrase-related protein 2 (CAH11_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA11: view

Function for CA11 Gene

Molecular function for CA11 Gene

UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.
GENATLAS Biochemistry:
acatalytic carbonic anhydrase related peptide XI,embedded between the secretor cluster and DBP,expressed abundantly in the brain (moderatly in spinal cord and thyroid,cerebral cortex,cerebellum putamen)

Phenotypes From GWAS Catalog for CA11 Gene

Gene Ontology (GO) - Molecular Function for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 NOT carbonate dehydratase activity TAS 9878252
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA11: view
genes like me logo Genes that share phenotypes with CA11: view

Animal Model Products

CRISPR Products

miRNA for CA11 Gene

miRTarBase miRNAs that target CA11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA11 Gene

Localization for CA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA11 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA11 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytoskeleton 2
mitochondrion 2
cytosol 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CA11: view

Pathways & Interactions for CA11 Gene

PathCards logo

SuperPathways for CA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CA11 Gene


No data available for Pathways by source and SIGNOR curated interactions for CA11 Gene

Drugs & Compounds for CA11 Gene

(7) Drugs for CA11 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 72
Brinzolamide Approved Pharma CA II inhibitor 67
Methazolamide Approved Pharma Carbonic anhydrase inhibitor 8
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 269
Dorzolamide HCl Pharma Carbonic anhydrase inhibitor 0

(5) ApexBio Compounds for CA11 Gene

Compound Action Cas Number
Brinzolamide CA II inhibitor 138890-62-7
Dorzolamide HCl Carbonic anhydrase inhibitor 130693-82-2
Methazolamide Carbonic anhydrase inhibitor 554-57-4
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
U-104 CAIX inhibitor 178606-66-1
genes like me logo Genes that share compounds with CA11: view

Transcripts for CA11 Gene

mRNA/cDNA for CA11 Gene

Unigene Clusters for CA11 Gene

Carbonic anhydrase XI:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA11

Alternative Splicing Database (ASD) splice patterns (SP) for CA11 Gene

No ASD Table

Relevant External Links for CA11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA11 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Putamen (basal ganglia) (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for CA11 Gene

This gene is overexpressed in Vitreous humor (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA11 Gene

Protein tissue co-expression partners for CA11 Gene

NURSA nuclear receptor signaling pathways regulating expression of CA11 Gene:


SOURCE GeneReport for Unigene cluster for CA11 Gene:


mRNA Expression by UniProt/SwissProt for CA11 Gene:

Tissue specificity: Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

Evidence on tissue expression from TISSUES for CA11 Gene

  • Nervous system(4.8)
  • Pancreas(4.1)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with CA11: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CA11 Gene

Orthologs for CA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CA11 35 34
  • 99.8 (n)
(Canis familiaris)
Mammalia CA11 35 34
  • 93.8 (n)
(Bos Taurus)
Mammalia CA11 35 34
  • 92.07 (n)
(Rattus norvegicus)
Mammalia Car11 34
  • 90.75 (n)
(Mus musculus)
Mammalia Car11 17 35 34
  • 90.24 (n)
(Monodelphis domestica)
Mammalia CA11 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
-- 35
  • 25 (a)
-- 35
  • 20 (a)
(Anolis carolinensis)
Reptilia CA11 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493884 34
  • 61.87 (n)
(Danio rerio)
Actinopterygii CA11 35
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32698 35
  • 34 (a)
CG1402 35
  • 32 (a)
(Caenorhabditis elegans)
Secernentea cah-2 35 36
  • 26 (a)
cah-1 35
  • 25 (a)
Species where no ortholog for CA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA11 Gene

Gene Tree for CA11 (if available)
Gene Tree for CA11 (if available)
Evolutionary constrained regions (ECRs) for CA11: view image

Paralogs for CA11 Gene

Paralogs for CA11 Gene

(8) SIMAP similar genes for CA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA11: view

Variants for CA11 Gene

Sequence variations from dbSNP and Humsavar for CA11 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000296980 -- 48,644,083(-) G/T intron_variant
rs1000364775 -- 48,641,437(-) T/A intron_variant
rs1000649208 -- 48,643,649(-) T/G intron_variant
rs1001041792 -- 48,646,156(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1001059334 -- 48,646,449(-) GGGGGGG/GGGGGG/GGGGGGGG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CA11 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for CA11 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA11 Gene

Disorders for CA11 Gene

Additional Disease Information for CA11

No disorders were found for CA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA11 Gene

Publications for CA11 Gene

  1. Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. (PMID: 9878252) Lovejoy DA … Tashian RE (Genomics 1998) 2 3 4 23 58
  2. cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. (PMID: 10350627) Fujikawa-Adachi K … Onishi S (Biochimica et biophysica acta 1999) 3 4 23 58
  3. Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3. (PMID: 9878543) Bellingham J … Gregory-Evans CY (Biochemical and biophysical research communications 1998) 3 4 23 58
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CA11 Gene

Sources for CA11 Gene

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