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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
CA11 (Carbonic Anhydrase 11) is a Protein Coding gene. Diseases associated with CA11 include Sialolithiasis. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004089 | NOT carbonate dehydratase activity | IEA,TAS | 9878252 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016836 | hydro-lyase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0016323 | basolateral plasma membrane | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006730 | one-carbon metabolic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Zonisamide | Approved, Investigational | Pharma | Target, inhibitor | Antiepileptic with anticonvulsant and mechanistic effect | 74 | |
Brinzolamide | Approved | Pharma | CA II inhibitor | 68 | ||
Methazolamide | Approved | Pharma | Carbonic anhydrase inhibitor | 8 | ||
Topiramate | Approved | Pharma | GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV | 277 | ||
Dorzolamide HCl | Pharma | Carbonic anhydrase inhibitor | 0 |
Compound | Action | Cas Number |
---|---|---|
Brinzolamide | CA II inhibitor | 138890-62-7 |
Dorzolamide HCl | Carbonic anhydrase inhibitor | 130693-82-2 |
Methazolamide | Carbonic anhydrase inhibitor | 554-57-4 |
Topiramate | GluR5 receptor antagonist,anticonvulsant | 97240-79-4 |
U-104 | CAIX inhibitor | 178606-66-1 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CA11 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CA11 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CA11 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Car11 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Car11 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CA11 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | CA11 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100493884 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CA11 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG32698 31 |
|
ManyToMany | |
CG1402 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | cah-2 31 32 |
|
ManyToMany | |
cah-1 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3617n100 | CNV | gain | 25217958 |
nsv9739 | CNV | gain+loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sialolithiasis |
|
|