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Aliases for CA11 Gene

Aliases for CA11 Gene

  • Carbonic Anhydrase 11 2 3 5
  • Carbonic Anhydrase-Related Protein 2 2 3 4
  • Carbonic Anhydrase-Related Protein XI 2 3
  • Carbonic Anhydrase XI 2 3
  • CA-RP XI 2 4
  • CA-RP II 3 4
  • CARP XI 3 4
  • CARP-2 3 4
  • CA-XI 3 4
  • Carbonic Anhydrase-Related Protein 11 3
  • CARPX1 3
  • CARP2 4

External Ids for CA11 Gene

Previous GeneCards Identifiers for CA11 Gene

  • GC19M049785
  • GC19M049509
  • GC19M053817
  • GC19M053833
  • GC19M049141
  • GC19M045520

Summaries for CA11 Gene

Entrez Gene Summary for CA11 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA11 Gene

CA11 (Carbonic Anhydrase 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA10.

UniProtKB/Swiss-Prot for CA11 Gene

  • Does not have a catalytic activity.

Gene Wiki entry for CA11 Gene

Additional gene information for CA11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA11 Gene

Genomics for CA11 Gene

GeneHancer (GH) Regulatory Elements for CA11 Gene

Promoters and enhancers for CA11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I048644 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 382 2.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B POLR2B CA11 GRWD1 SNORD35A NOP53-AS1 ALDH16A1 SNORD35B PRR12 NOP53 RPS11 SNRNP70
GH19I048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.7 -317.7 -317717 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PTOV1-AS2 IRF3 PRR12 SNORD35A SNORD35B
GH19I047741 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.7 +902.4 902391 5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 ZNF548 NOP53 ZC3H4 BICRA SELENOW GRWD1 RASIP1 CA11 SNORD23 ZSWIM9 NOP53-AS1
GH19I049579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.7 -934.5 -934478 2.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 PRRG2 NOSIP PRR12 NUP62 POLD1 SNORD35A SNORD35B IRF3 PIH1D1 ALDH16A1
GH19I048328 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +314.6 314646 5.8 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 POLR2B BICRA GRWD1 TMEM143 SNRNP70 NOP53-AS1 CA11 NOP53 KDELR1 RPL18 ZSWIM9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CA11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CA11 gene promoter:

Genomic Locations for CA11 Gene

Genomic Locations for CA11 Gene
chr19:48,637,942-48,646,312
(GRCh38/hg38)
Size:
8,371 bases
Orientation:
Minus strand
chr19:49,141,199-49,149,569
(GRCh37/hg19)

Genomic View for CA11 Gene

Genes around CA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA11 Gene

Proteins for CA11 Gene

  • Protein details for CA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75493-CAH11_HUMAN
    Recommended name:
    Carbonic anhydrase-related protein 11
    Protein Accession:
    O75493
    Secondary Accessions:
    • O60596
    • Q6FHI1
    • Q9UEC4

    Protein attributes for CA11 Gene

    Size:
    328 amino acids
    Molecular mass:
    36238 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CA11 Gene

Post-translational modifications for CA11 Gene

  • Glycosylation at posLast=118118, posLast=170170, and posLast=260260
  • Modification sites at PhosphoSitePlus

Other Protein References for CA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CA11 Gene

Domains & Families for CA11 Gene

Gene Families for CA11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75493

UniProtKB/Swiss-Prot:

CAH11_HUMAN :
  • Belongs to the alpha-carbonic anhydrase family.
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA11: view

Function for CA11 Gene

Molecular function for CA11 Gene

GENATLAS Biochemistry:
acatalytic carbonic anhydrase related peptide XI,embedded between the secretor cluster and DBP,expressed abundantly in the brain (moderatly in spinal cord and thyroid,cerebral cortex,cerebellum putamen)
UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.

Phenotypes From GWAS Catalog for CA11 Gene

Gene Ontology (GO) - Molecular Function for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 NOT carbonate dehydratase activity TAS 9878252
genes like me logo Genes that share ontologies with CA11: view
genes like me logo Genes that share phenotypes with CA11: view

Animal Model Products

CRISPR Products

miRNA for CA11 Gene

miRTarBase miRNAs that target CA11

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA11 Gene

Localization for CA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA11 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CA11: view

Pathways & Interactions for CA11 Gene

No Data Available

Interacting Proteins for CA11 Gene

Gene Ontology (GO) - Biological Process for CA11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CA11 Gene

Drugs & Compounds for CA11 Gene

(7) Drugs for CA11 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 69
Brinzolamide Approved Pharma CA II inhibitor 63
Methazolamide Approved Pharma Carbonic anhydrase inhibitor 8
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 257
Dorzolamide HCl Pharma Carbonic anhydrase inhibitor 0

(5) ApexBio Compounds for CA11 Gene

Compound Action Cas Number
Brinzolamide CA II inhibitor 138890-62-7
Dorzolamide HCl Carbonic anhydrase inhibitor 130693-82-2
Methazolamide Carbonic anhydrase inhibitor 554-57-4
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
U-104 CAIX inhibitor 178606-66-1
genes like me logo Genes that share compounds with CA11: view

Drug Products

Transcripts for CA11 Gene

Unigene Clusters for CA11 Gene

Carbonic anhydrase XI:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA11 Gene

No ASD Table

Relevant External Links for CA11 Gene

GeneLoc Exon Structure for
CA11
ECgene alternative splicing isoforms for
CA11

Expression for CA11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA11 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Putamen (basal ganglia) (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for CA11 Gene

This gene is overexpressed in Vitreous humor (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CA11 Gene



Protein tissue co-expression partners for CA11 Gene

NURSA nuclear receptor signaling pathways regulating expression of CA11 Gene:

CA11

SOURCE GeneReport for Unigene cluster for CA11 Gene:

Hs.428446

mRNA Expression by UniProt/SwissProt for CA11 Gene:

O75493-CAH11_HUMAN
Tissue specificity: Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.

Evidence on tissue expression from TISSUES for CA11 Gene

  • Nervous system(4.8)
  • Pancreas(4.1)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with CA11: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CA11 Gene

Orthologs for CA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA11 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CA11 33 34
  • 93.8 (n)
cow
(Bos Taurus)
Mammalia CA11 33 34
  • 92.07 (n)
rat
(Rattus norvegicus)
Mammalia Car11 33
  • 90.75 (n)
mouse
(Mus musculus)
Mammalia Car11 33 16 34
  • 90.24 (n)
oppossum
(Monodelphis domestica)
Mammalia CA11 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CA11 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493884 33
  • 61.87 (n)
zebrafish
(Danio rerio)
Actinopterygii CA11 34
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32698 34
  • 34 (a)
ManyToMany
CG1402 34
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cah-2 35 34
  • 35 (a)
cah-1 34
  • 25 (a)
ManyToMany
Species where no ortholog for CA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA11 Gene

ENSEMBL:
Gene Tree for CA11 (if available)
TreeFam:
Gene Tree for CA11 (if available)

Paralogs for CA11 Gene

Paralogs for CA11 Gene

(8) SIMAP similar genes for CA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA11: view

Variants for CA11 Gene

Sequence variations from dbSNP and Humsavar for CA11 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000296980 -- 48,644,083(-) G/T intron_variant
rs1000364775 -- 48,641,437(-) T/A intron_variant
rs1000649208 -- 48,643,649(-) T/G intron_variant
rs1001041792 -- 48,646,156(-) T/C 5_prime_UTR_variant, non_coding_transcript_variant
rs1001059334 -- 48,646,449(-) GGGGGGG/GGGGGG/GGGGGGGG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CA11 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for CA11 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CA11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA11 Gene

Disorders for CA11 Gene

Additional Disease Information for CA11

No disorders were found for CA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA11 Gene

Publications for CA11 Gene

  1. Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. (PMID: 9878252) Lovejoy DA … Tashian RE (Genomics 1998) 2 3 4 22 58
  2. cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. (PMID: 10350627) Fujikawa-Adachi K … Onishi S (Biochimica et biophysica acta 1999) 3 4 22 58
  3. Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3. (PMID: 9878543) Bellingham J … Gregory-Evans CY (Biochemical and biophysical research communications 1998) 3 4 22 58
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CA11 Gene

Sources for CA11 Gene

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