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Aliases for CA10 Gene

Aliases for CA10 Gene

  • Carbonic Anhydrase 10 2 3 5
  • Carbonic Anhydrase-Related Protein X 3 4
  • Carbonic Anhydrase X 2 3
  • CA-RP X 3 4
  • CARP X 3 4
  • Carbonic Anhydrase-Related Protein 10 3
  • Cerebral Protein-15 3
  • Cerebral Protein 15 4
  • HUCEP-15 3
  • CA-RPX 3
  • CARPX 3

External Ids for CA10 Gene

Previous GeneCards Identifiers for CA10 Gene

  • GC17U990008
  • GC17M052189
  • GC17M050049
  • GC17M050182
  • GC17M047062
  • GC17M049707
  • GC17M045077

Summaries for CA10 Gene

Entrez Gene Summary for CA10 Gene

  • This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA10 Gene

CA10 (Carbonic Anhydrase 10) is a Protein Coding gene. Diseases associated with CA10 include Herpangina and Non-Suppurative Otitis Media. An important paralog of this gene is CA11.

UniProtKB/Swiss-Prot for CA10 Gene

  • Does not have a catalytic activity.

Gene Wiki entry for CA10 Gene

Additional gene information for CA10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA10 Gene

Genomics for CA10 Gene

GeneHancer (GH) Regulatory Elements for CA10 Gene

Promoters and enhancers for CA10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J052158 Promoter/Enhancer 1 EPDnew ENCODE 650.7 +1.3 1264 0.2 CTCF ZFHX2 REST EZH2 CA10 ENSG00000279743
GH17J052160 Promoter 0.7 EPDnew 650.7 +1.9 1865 0.1 SUZ12 EZH2 CA10 ENSG00000279743
GH17J052159 Promoter 0.5 EPDnew 650.7 0.0 -11 0.1 CA10 LOC105371829
GH17J052156 Enhancer 0.2 FANTOM5 11.6 +3.2 3206 0.2 CA10 ENSG00000279743
GH17J051904 Enhancer 0.2 FANTOM5 7.2 +255.8 255817 0 CA10 ENSG00000279743
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CA10 gene promoter:
  • Egr-4
  • Sox5
  • Pax-2
  • E2F-1

Genomic Locations for CA10 Gene

Genomic Locations for CA10 Gene
529,705 bases
Minus strand
529,704 bases
Minus strand

Genomic View for CA10 Gene

Genes around CA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA10 Gene

Proteins for CA10 Gene

  • Protein details for CA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase-related protein 10
    Protein Accession:
    Secondary Accessions:
    • B2R7J0
    • B4DGL6

    Protein attributes for CA10 Gene

    328 amino acids
    Molecular mass:
    37563 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CA10 Gene


neXtProt entry for CA10 Gene

Post-translational modifications for CA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CA10 Gene

Domains & Families for CA10 Gene

Gene Families for CA10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CA10 Gene

Suggested Antigen Peptide Sequences for CA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA10: view

Function for CA10 Gene

Molecular function for CA10 Gene

UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.

Phenotypes From GWAS Catalog for CA10 Gene

Gene Ontology (GO) - Molecular Function for CA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CA10: view
genes like me logo Genes that share phenotypes with CA10: view

Animal Model Products

CRISPR Products

miRNA for CA10 Gene

miRTarBase miRNAs that target CA10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA10 Gene

Localization for CA10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA10 gene
Compartment Confidence
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CA10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CA10 Gene

Pathways & Interactions for CA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development NAS 11311946
genes like me logo Genes that share ontologies with CA10: view

No data available for Pathways by source and SIGNOR curated interactions for CA10 Gene

Drugs & Compounds for CA10 Gene

(3) Drugs for CA10 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 69
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Montelukast Approved Pharma Antagonist 280
genes like me logo Genes that share compounds with CA10: view

Transcripts for CA10 Gene

mRNA/cDNA for CA10 Gene

Unigene Clusters for CA10 Gene

Carbonic anhydrase X:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CA10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP3: -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for CA10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA10 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.2), Brain - Cerebellum (x9.2), Brain - Frontal Cortex (BA9) (x5.4), Brain - Anterior cingulate cortex (BA24) (x5.2), and Brain - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for CA10 Gene

This gene is overexpressed in Vitreous humor (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA10 Gene

Protein tissue co-expression partners for CA10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CA10 Gene:


SOURCE GeneReport for Unigene cluster for CA10 Gene:


mRNA Expression by UniProt/SwissProt for CA10 Gene:

Tissue specificity: Strong expression in brain and central nervous system.

Evidence on tissue expression from TISSUES for CA10 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CA10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CA10 Gene

Orthologs for CA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia CA10 34
  • 100 (a)
(Pan troglodytes)
Mammalia CA10 34 33
  • 99.8 (n)
(Canis familiaris)
Mammalia CA10 34 33
  • 96.85 (n)
(Ornithorhynchus anatinus)
Mammalia CA10 34
  • 96 (a)
(Bos Taurus)
Mammalia CA10 34 33
  • 95.53 (n)
(Mus musculus)
Mammalia Car10 16 34 33
  • 94.51 (n)
(Rattus norvegicus)
Mammalia Ca10 33
  • 94 (n)
(Gallus gallus)
Aves CA10 34 33
  • 86.79 (n)
(Anolis carolinensis)
Reptilia CA10 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca10 33
  • 80.89 (n)
(Danio rerio)
Actinopterygii ca10a 34 33
  • 79.37 (n)
wufd54f06 33
fruit fly
(Drosophila melanogaster)
Insecta CG32698 34 33
  • 52.91 (n)
CG1402 34
  • 37 (a)
CG18672 34
  • 26 (a)
CG11284 34
  • 26 (a)
CG3940 34
  • 24 (a)
CG10899 34
  • 24 (a)
CG6074 34
  • 24 (a)
CG5379 34
  • 23 (a)
CG3669 34
  • 23 (a)
CG18673 34
  • 22 (a)
CG9235 34
  • 20 (a)
CG15227 34
  • 19 (a)
CG12309 34
  • 13 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000688 33
  • 52.77 (n)
(Caenorhabditis elegans)
Secernentea cah-2 34 33
  • 47.37 (n)
cah-1 34
  • 27 (a)
cah-6 34
  • 23 (a)
cah-4 34
  • 23 (a)
Species where no ortholog for CA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA10 Gene

Gene Tree for CA10 (if available)
Gene Tree for CA10 (if available)
Evolutionary constrained regions (ECRs) for CA10: view image

Paralogs for CA10 Gene

Paralogs for CA10 Gene

(11) SIMAP similar genes for CA10 Gene using alignment to 6 proteins:

  • I3L0J7_HUMAN
  • I3L375_HUMAN
  • I3NI54_HUMAN
genes like me logo Genes that share paralogs with CA10: view

Variants for CA10 Gene

Sequence variations from dbSNP and Humsavar for CA10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000000005 -- 51,974,498(-) AAACAAA/AAA genic_upstream_transcript_variant, intron_variant
rs1000000243 -- 51,813,198(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000007518 -- 51,972,550(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000010830 -- 51,725,676(-) C/T intron_variant
rs1000015708 -- 52,082,799(-) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CA10 Gene

Variant ID Type Subtype PubMed ID
dgv554e199 CNV deletion 23128226
dgv5690n54 CNV loss 21841781
dgv952e212 CNV loss 25503493
esv24039 CNV loss 19812545
esv2567906 CNV insertion 19546169
esv2670652 CNV deletion 23128226
esv2673970 CNV deletion 23128226
esv2716046 CNV deletion 23290073
esv2716047 CNV deletion 23290073
esv2760447 CNV gain 21179565
esv3306708 CNV mobile element insertion 20981092
esv3309263 CNV mobile element insertion 20981092
esv3364542 CNV insertion 20981092
esv3396689 CNV insertion 20981092
esv3396976 CNV insertion 20981092
esv34090 CNV loss 18971310
esv3554547 CNV deletion 23714750
esv3582814 CNV loss 25503493
esv3640771 CNV loss 21293372
esv3640772 CNV loss 21293372
esv3640773 CNV loss 21293372
esv3640774 CNV loss 21293372
esv3640776 CNV loss 21293372
esv3640777 CNV loss 21293372
esv3893028 CNV gain 25118596
esv4530 CNV loss 18987735
esv9578 CNV loss 19470904
nsv1110712 CNV insertion 24896259
nsv1119458 CNV insertion 24896259
nsv1129594 CNV tandem duplication 24896259
nsv1138556 CNV deletion 24896259
nsv2086 CNV insertion 18451855
nsv2087 CNV insertion 18451855
nsv472231 CNV novel sequence insertion 20440878
nsv507844 OTHER sequence alteration 20534489
nsv575551 CNV loss 21841781
nsv575552 CNV loss 21841781
nsv828040 CNV gain 20364138
nsv828041 CNV loss 20364138
nsv828043 CNV loss 20364138
nsv833482 CNV gain 17160897
nsv962341 CNV duplication 23825009

Variation tolerance for CA10 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CA10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA10 Gene

Disorders for CA10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CA10 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • vesicular pharyngitis
non-suppurative otitis media
  • nonsuppurative otitis media
  • chondroblastoma of bone
hand, foot and mouth disease
  • vesicular stomatitis and exanthem
- elite association - COSMIC cancer census association via MalaCards
Search CA10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CA10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA10 Gene

Publications for CA10 Gene

  1. cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain. (PMID: 11311946) Okamoto N … Onishi S (Biochimica et biophysica acta 2001) 3 4 22 58
  2. CCG repeats in cDNAs from human brain. (PMID: 9921901) Kleiderlein JJ … Margolis RL (Human genetics 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58

Products for CA10 Gene

Sources for CA10 Gene

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