Aliases for CA1 Gene
External Ids for CA1 Gene
Previous GeneCards Identifiers for CA1 Gene
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
GeneCards Summary for CA1 Gene
CA1 (Carbonic Anhydrase 1) is a Protein Coding gene. Diseases associated with CA1 include Transient Global Amnesia and Occlusion Precerebral Artery. Among its related pathways are C-MYB transcription factor network and Erythrocytes take up carbon dioxide and release oxygen. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity and hydro-lyase activity. An important paralog of this gene is CA2.
UniProtKB/Swiss-Prot for CA1 Gene
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.