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Aliases for C9orf85 Gene

Aliases for C9orf85 Gene

  • Chromosome 9 Open Reading Frame 85 2 3 5
  • Uncharacterized Protein C9orf85 3

External Ids for C9orf85 Gene

Previous GeneCards Identifiers for C9orf85 Gene

  • GC09P069983
  • GC09P071755
  • GC09P073716
  • GC09P074526
  • GC09P044349

Summaries for C9orf85 Gene

GeneCards Summary for C9orf85 Gene

C9orf85 (Chromosome 9 Open Reading Frame 85) is a Protein Coding gene.

Additional gene information for C9orf85 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf85 Gene

Genomics for C9orf85 Gene

GeneHancer (GH) Regulatory Elements for C9orf85 Gene

Promoters and enhancers for C9orf85 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J071908 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 655.8 -0.4 -402 4.1 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B C9orf85 ABHD17B ENSG00000200922 GC09M071903
GH09J071791 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -116.4 -116441 6.1 PKNOX1 FOXA2 BATF ETS1 YY1 TEAD3 NFATC1 FOSL2 ETV6 IKZF2 CEMIP2 ABHD17B C9orf85 LOC100420790 GC09P071678
GH09J071944 Enhancer 0.6 ENCODE dbSUPER 16.6 +34.1 34059 2.3 STAT1 GATA3 C9orf85 ABHD17B GC09M071961 PIR47528
GH09J071806 Enhancer 0.9 Ensembl ENCODE 10.8 -104.3 -104258 0.3 ELF3 CTCF RAD21 RFX5 YY1 GATA3 SMC3 ZNF143 ZNF444 RUNX3 ABHD17B C9orf85 LOC100420790 CEMIP2
GH09J071961 Enhancer 0.5 ENCODE 16.6 +51.1 51115 1.6 SP1 RFX1 RXRA CREB1 ELF1 BMI1 FOXA1 GC09M071961 C9orf85 ABHD17B CEMIP2 HSPB1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C9orf85 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C9orf85 gene promoter:

Genomic Locations for C9orf85 Gene

Genomic Locations for C9orf85 Gene
chr9:71,911,321-71,986,054
(GRCh38/hg38)
Size:
74,734 bases
Orientation:
Plus strand
chr9:74,526,423-74,600,970
(GRCh37/hg19)

Genomic View for C9orf85 Gene

Genes around C9orf85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf85 Gene

Proteins for C9orf85 Gene

  • Protein details for C9orf85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MD7-CI085_HUMAN
    Recommended name:
    Uncharacterized protein C9orf85
    Protein Accession:
    Q96MD7
    Secondary Accessions:
    • Q5W0N1
    • Q5W0N3
    • Q6PJW9
    • Q86U95

    Protein attributes for C9orf85 Gene

    Size:
    179 amino acids
    Molecular mass:
    20166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH72769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C9orf85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf85 Gene

Post-translational modifications for C9orf85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf85 Gene

No data available for DME Specific Peptides for C9orf85 Gene

Domains & Families for C9orf85 Gene

Gene Families for C9orf85 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C9orf85 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf85: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf85 Gene

Function for C9orf85 Gene

genes like me logo Genes that share phenotypes with C9orf85: view

Animal Model Products

miRNA for C9orf85 Gene

miRTarBase miRNAs that target C9orf85

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf85 Gene

Localization for C9orf85 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf85 gene
Compartment Confidence
nucleus 3
golgi apparatus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf85 Gene

Pathways & Interactions for C9orf85 Gene

SuperPathways for C9orf85 Gene

No Data Available

Interacting Proteins for C9orf85 Gene

Selected Interacting proteins: Q96MD7-CI085_HUMAN for C9orf85 Gene via IID

Symbol External ID(s) Details
IMP3
OSGEP

Gene Ontology (GO) - Biological Process for C9orf85 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf85 Gene

Drugs & Compounds for C9orf85 Gene

No Compound Related Data Available

Transcripts for C9orf85 Gene

mRNA/cDNA for C9orf85 Gene

Unigene Clusters for C9orf85 Gene

Chromosome 9 open reading frame 85:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf85 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7:
SP8: - - - - - - -

Relevant External Links for C9orf85 Gene

GeneLoc Exon Structure for
C9orf85
ECgene alternative splicing isoforms for
C9orf85

Expression for C9orf85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf85 Gene

Protein differential expression in normal tissues from HIPED for C9orf85 Gene

This gene is overexpressed in Lung (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C9orf85 Gene



Protein tissue co-expression partners for C9orf85 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C9orf85 Gene:

C9orf85

SOURCE GeneReport for Unigene cluster for C9orf85 Gene:

Hs.534190
genes like me logo Genes that share expression patterns with C9orf85: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf85 Gene

Orthologs for C9orf85 Gene

This gene was present in the common ancestor of animals.

Orthologs for C9orf85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9orf85 34
  • 100 (a)
OneToOne
C9H9orf85 33
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia C1H9orf85 33
  • 91.67 (n)
C9orf85 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H9orf85 33
  • 91.36 (n)
-- 34
  • 89 (a)
OneToMany
C8H9ORF85 34
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1359158 33
  • 88.73 (n)
mouse
(Mus musculus)
Mammalia 1110059E24Rik 16 34 33
  • 84.52 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf85 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf85 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9orf85 33
  • 69.95 (n)
C9orf85 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf85 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf85 33
  • 69.95 (n)
Str.6988 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14278 33
zebrafish
(Danio rerio)
Actinopterygii zgc:101016 33
  • 65.93 (n)
C5H9orf85 34
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4222 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003732 33
  • 54.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8675 34 33
  • 52.48 (n)
OneToOne
Species where no ortholog for C9orf85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf85 Gene

ENSEMBL:
Gene Tree for C9orf85 (if available)
TreeFam:
Gene Tree for C9orf85 (if available)

Paralogs for C9orf85 Gene

(19) SIMAP similar genes for C9orf85 Gene using alignment to 4 proteins:

  • CI085_HUMAN
  • E9PN32_HUMAN
  • F6X0R3_HUMAN
  • H3BLX8_HUMAN

Pseudogenes.org Pseudogenes for C9orf85 Gene

genes like me logo Genes that share paralogs with C9orf85: view

No data available for Paralogs for C9orf85 Gene

Variants for C9orf85 Gene

Sequence variations from dbSNP and Humsavar for C9orf85 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000000863 -- 71,925,504(+) A/C intron_variant
rs1000079004 -- 71,977,992(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000116613 -- 71,925,212(+) A/G intron_variant
rs1000153171 -- 71,971,133(+) T/C intron_variant
rs1000180607 -- 71,972,668(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf85 Gene

Variant ID Type Subtype PubMed ID
esv2761535 CNV gain 21179565
esv3620617 CNV loss 21293372
esv3620620 CNV loss 21293372
nsv1050324 CNV gain 25217958
nsv521672 CNV loss 19592680
nsv614609 CNV loss 21841781
nsv831618 CNV loss 17160897

Variation tolerance for C9orf85 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C9orf85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf85 Gene

Disorders for C9orf85 Gene

Additional Disease Information for C9orf85

No disorders were found for C9orf85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf85 Gene

Publications for C9orf85 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58

Products for C9orf85 Gene

Sources for C9orf85 Gene

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