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Aliases for C9orf84 Gene

Aliases for C9orf84 Gene

  • Chromosome 9 Open Reading Frame 84 2 3 5

External Ids for C9orf84 Gene

Previous GeneCards Identifiers for C9orf84 Gene

  • GC09M109828
  • GC09M109880
  • GC09M111528
  • GC09M113488
  • GC09M114448
  • GC09M084047

Summaries for C9orf84 Gene

GeneCards Summary for C9orf84 Gene

C9orf84 (Chromosome 9 Open Reading Frame 84) is a Protein Coding gene.

Additional gene information for C9orf84 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf84 Gene

Genomics for C9orf84 Gene

GeneHancer (GH) Regulatory Elements for C9orf84 Gene

Promoters and enhancers for C9orf84 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I111794 Enhancer 0.6 ENCODE 550.8 0.0 -28 1 ELK4 USF1 NFYA MAX USF2 E2F4 POLR2A NFYB ZBTB33 E2F6 C9orf84 GNG10 PTBP3 ENSG00000224067
GH09I111783 Promoter 0.5 EPDnew 550.4 +11.5 11495 0.1 C9orf84 RNU6-1013P GC09P111683
GH09I111760 Promoter 0.5 EPDnew 550.3 +35.5 35475 0.1 C9orf84 GC09P111683
GH09I111759 Enhancer 1 Ensembl ENCODE 23.1 +34.8 34804 1.2 CTCF PKNOX1 ARNT TEAD4 ASH1L E4F1 IRF4 RAD21 RFX5 YY1 C9orf84 ENSG00000224067 GNG10 GC09P111683
GH09I112072 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 -279.2 -279188 4 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 ZNF766 GATA2 ARID2 ZNF143 C9orf84 ENSG00000224067 RNU6-1013P SUSD1 UGCG GNG10 PTGR1 ENSG00000259953 RNU6-855P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C9orf84 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C9orf84 gene promoter:

Genomic Locations for C9orf84 Gene

Genomic Locations for C9orf84 Gene
108,836 bases
Minus strand

Genomic View for C9orf84 Gene

Genes around C9orf84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf84 Gene

Proteins for C9orf84 Gene

  • Protein details for C9orf84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C9orf84
    Protein Accession:
    Secondary Accessions:
    • A2A2V3
    • Q2M1H8
    • Q96M73

    Protein attributes for C9orf84 Gene

    1444 amino acids
    Molecular mass:
    165202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C9orf84 Gene


neXtProt entry for C9orf84 Gene

Post-translational modifications for C9orf84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C9orf84 Gene

Domains & Families for C9orf84 Gene

Gene Families for C9orf84 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C9orf84 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf84: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf84 Gene

Function for C9orf84 Gene

Phenotypes From GWAS Catalog for C9orf84 Gene

genes like me logo Genes that share phenotypes with C9orf84: view

miRNA for C9orf84 Gene

miRTarBase miRNAs that target C9orf84

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf84 Gene

Localization for C9orf84 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf84 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf84 Gene

Pathways & Interactions for C9orf84 Gene

SuperPathways for C9orf84 Gene

No Data Available

Interacting Proteins for C9orf84 Gene

Gene Ontology (GO) - Biological Process for C9orf84 Gene


No data available for Pathways by source and SIGNOR curated interactions for C9orf84 Gene

Drugs & Compounds for C9orf84 Gene

No Compound Related Data Available

Transcripts for C9orf84 Gene

Unigene Clusters for C9orf84 Gene

Chromosome 9 open reading frame 84:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf84 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32

Relevant External Links for C9orf84 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C9orf84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf84 Gene

This gene is overexpressed in Testis (x28.4) and Kidney - Cortex (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of C9orf84 Gene:


SOURCE GeneReport for Unigene cluster for C9orf84 Gene:

genes like me logo Genes that share expression patterns with C9orf84: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf84 Gene

Orthologs for C9orf84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf84 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C9H9orf84 33
  • 99.4 (n)
C9orf84 34
  • 98 (a)
(Canis familiaris)
Mammalia C11H9orf84 33
  • 85.53 (n)
C9orf84 34
  • 74 (a)
(Bos Taurus)
Mammalia LOC617568 33
  • 84.96 (n)
C9orf84 34
  • 74 (a)
(Mus musculus)
Mammalia AI481877 33 16 34
  • 74.51 (n)
(Rattus norvegicus)
Mammalia LOC686050 33
  • 72.97 (n)
(Monodelphis domestica)
Mammalia C9orf84 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia C9orf84 34
  • 27 (a)
(Gallus gallus)
Aves CZH9orf84 33
  • 59.1 (n)
C9orf84 34
  • 43 (a)
(Anolis carolinensis)
Reptilia C9orf84 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487050 33
  • 51.82 (n)
Species where no ortholog for C9orf84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf84 Gene

Gene Tree for C9orf84 (if available)
Gene Tree for C9orf84 (if available)

Paralogs for C9orf84 Gene

No data available for Paralogs for C9orf84 Gene

Variants for C9orf84 Gene

Sequence variations from dbSNP and Humsavar for C9orf84 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000040329 -- 111,697,093(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000081497 -- 111,729,886(-) C/A/T intron_variant
rs1000106755 -- 111,740,785(-) T/G intron_variant
rs1000137704 -- 111,739,875(-) A/T intron_variant
rs1000191927 -- 111,739,542(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf84 Gene

Variant ID Type Subtype PubMed ID
dgv7700n100 CNV gain 25217958
esv1003380 CNV deletion 20482838
esv1650763 CNV deletion 17803354
esv2420162 CNV deletion 18987734
esv2738937 CNV deletion 23290073
esv2738938 CNV deletion 23290073
esv2761550 CNV gain 21179565
nsv1110050 CNV deletion 24896259
nsv466486 CNV gain 19166990
nsv615193 CNV gain 21841781
nsv615194 CNV loss 21841781
nsv6667 CNV insertion 18451855
nsv831690 CNV loss 17160897

Variation tolerance for C9orf84 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.37; 98.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C9orf84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf84 Gene

Disorders for C9orf84 Gene

Additional Disease Information for C9orf84

No disorders were found for C9orf84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf84 Gene

Publications for C9orf84 Gene

  1. SHOC1 and PTD form an XPF-ERCC1-like complex that is required for formation of class I crossovers. (PMID: 21771883) Macaisne N … Mercier R (Journal of cell science 2011) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3 58
  5. SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers. (PMID: 18812090) Macaisne N … Mercier R (Current biology : CB 2008) 3 58

Products for C9orf84 Gene

Sources for C9orf84 Gene

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